Insulin resistance in patients with depression and its changes during the clinical course of depression: Minimal model analysis

Okamura, Fumio; Tashiro, Atsushi; Utumi, Atsushi; Imai, Tetsuo; Suchi, Takatosi; Tamura, Daisaku; Sato, Yoshinori; Suzuki, Susumu; Hongo, Michio

doi:10.1053/meta.2000.9515

Cited by 195 publications

(138 citation statements)

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“…These data indicate a significant decrease in whole body insulin sensitivity after oral intake of olanzapine, 10 mg/day for 10 days, after 80 min (po0.015), 100 min (po0.001), and 120 min (po0.0001) of glucose clamp. Effects of olanzapine and ziprasidone J Sacher et al population but is not associated with the risk of DM2 during antipsychotic treatment does not seem very likely given the evidence for a higher rather than a lower prevalence of DM2 in patients suffering from a major mental disorder in almost all data sets published to date (Mukherjee et al, 1996;Dixon et al, 2000;Okamura et al, 2000;Mokdad et al, 2001;Haupt and Newcomer, 2002;Newcomer et al, 2002;Ryan et al, 2003;Newcomer, 2004;Haupt et al, 2007). A second metabolic effect is depicted in Figure 2 and Table 2.…”

Section: Discussionmentioning

confidence: 99%

Effects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers

Sacher

Mossaheb

Spindelegger

et al. 2007

Neuropsychopharmacol

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Atypical antipsychotics have been linked to a higher risk for glucose intolerance, and consequentially the development of type 2 diabetes mellitus (DM2). We have therefore set out to investigate the acute effects of oral administration of olanzapine and ziprasidone on whole body insulin sensitivity in healthy subjects. Using the standardized hyperinsulinemic euglycemic clamp technique we compared whole body insulin sensitivity of 29 healthy male volunteers after oral intake of either olanzapine 10 mg/day (n ¼ 14) or ziprasidone 80 mg/day (n ¼ 15) for 10 days. A significant decrease (po0.001) in whole body insulin sensitivity from 5.7 ml/h/kg ( ¼ mean, SM ¼ 0.4 ml/h/kg) at baseline to 4.7 ml/h/kg ( ¼ mean, SM ¼ 0.3 ml/h/kg) after oral intake of olanzapine (10 mg/day) for 10 days was observed. The ziprasidone (80 mg/day) group did not show any significant difference (5.2 ± 0.3 ml/h/kg baseline vs 5.1 ± 0.3 ml/h/kg) after 10 days of oral intake. Our main finding demonstrates that oral administration of olanzapine but not ziprasidone leads to a decrease in whole body insulin sensitivity in response to a hyperinsulinemic euglycemic challenge. Our finding is suggestive that not all atypical antipsychotics cause acute direct effects on glucose disposal and that accurate determination of side effect profile should be performed when choosing an atypical antipsychotic.

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Section: Discussionmentioning

confidence: 99%

Effects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers

Sacher

Mossaheb

Spindelegger

et al. 2007

Neuropsychopharmacol

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“…8,15,16,18 -20 Increased sympathetic activity, enhanced cardiovascular reactivity, and reduced parasympathetic tone have also been strongly implicated in the pathogenesis of IRS 10,[21][22][23][24][25][26][27][28][29] and in the development and progression of atherosclerosis 27,28,30,31 and cardiovascular disease. 21,25,28 -36 In addition, recent research offers compelling evidence that chronic psychological stress and negative affective states contribute significantly to the pathogenesis and progression of insulin resistance, [37][38][39][40][41] glucose intolerance, 38 hypertension, [42][43][44][45][46] dyslipidemia, 38,41,47 and other IRS-related conditions 28,37,48 -55 and ultimately, increase risk for CVD morbidity and mortality. 28,32,43,44,46,52,56 -60 Not only can IRS-related conditions be exacerbated by lifestyle variables, such as smoking, lack of exercise, and poor diet, but these conditions can interact with one another in a destructive manner, 61 likely accounting for their synergistic effect on CVD risk.…”

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confidence: 99%

Risk Indices Associated with the Insulin Resistance Syndrome, Cardiovascular Disease, and Possible Protection with Yoga: A Systematic Review

Innes

Bourguignon²,

Taylor³

2005

The Journal of the American Board of Family Medicine

323

261

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Objective: To conduct a systematic review of published literature regarding the effects of yoga, a promising mind-body therapy, on specific anthropometric and physiologic indices of cardiovascular disease (CVD) risk and on related clinical endpoints.Methods: We performed a literature search using 4 computerized English and Indian scientific databases. The search was restricted to original studies (1970 to 2004) evaluating the effects of yoga on CVD or indices of CVD risk associated with the insulin resistance syndrome (IRS). Randomized controlled trials (RCTs), nonrandomized controlled trials, uncontrolled (pre and post) clinical trials, and cross-sectional (observational) studies were included if they met specific criteria. Data were extracted regarding study design, setting, population size and characteristics, intervention type and duration, comparison group or condition, outcome assessment, data analysis and presentation, follow-up, and key results, and the quality of each study was evaluated according to specific predetermined criteria.Results : ing number of developing countries. [5][6][7] Leading to premature morbidity and mortality, and to preventable losses of employment, earnings, and quality of life, CVD is clearly of pressing clinical and economic significance, underscoring the need for effective primary prevention efforts that target common, modifiable risk factors. Prominent among these are the physiologic and anthropometric risk factors associated with the insulin resistance syndrome (IRS), and the neuroendocrine and psychosocial alterations that may both predispose to and result from these IRS-related abnormalities. The IRS, also referred to as syndrome X or the metabolic syndrome, is a cluster of metabolic and hemodynamic abnormalities that both collectively and independently predict the development of atherosclerosis and CVD. 4,8 -11 Core features of the IRS are insulin resistance, glucose intolerance, atherogenic dyslipidemia, high blood pressure, and

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“…They had, in comparison with controls, higher concentrations of plasma glucose, insulin, CD-LDL and values of HOMA-IR. Depressive disorder is a heterogeneous disease with multiple pathogenetic factors and (according to some authors) IR could also play a role (Okamura et al 2000). Increased insulin resistance could be the factor behind the known association of depression with DM2 and CVD (Musselman et al 1998), at least in some subtypes of DD.…”

Section: Discussionmentioning

confidence: 99%

“…The key role in the etiopathogenesis of both MetS and DM2 is inscribed to insulin resistance (IR) (Reaven 2002), which (according to some authors) is also connected with the pathogenesis of dementia (Carantoni et al 2000) and DD (Okamura et al 2000). The question whether IR precedes DD or vice versa can not be yet clearly answered, but when the prospective relationships between DD and DM2 over the lifespan were analysed in comprehensive metaanalysis, depression was associated with a 60% increased risk of DM2, while DM2 was associated with only modest increased risk of depression (Mezuk et al 2008).…”

mentioning

confidence: 99%

Fatty Acid CoA Ligase-4 Gene Polymorphism Influences Fatty Acid Metabolism in Metabolic Syndrome, but not in Depression

Zeman

Vecka

Jáchymová³

et al. 2009

Tohoku J. Exp. Med.

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Insulin resistance in patients with depression and its changes during the clinical course of depression: Minimal model analysis

Cited by 195 publications

References 0 publications

Effects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers

Effects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers

Risk Indices Associated with the Insulin Resistance Syndrome, Cardiovascular Disease, and Possible Protection with Yoga: A Systematic Review

Fatty Acid CoA Ligase-4 Gene Polymorphism Influences Fatty Acid Metabolism in Metabolic Syndrome, but not in Depression

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