Insulin resistance indices and coronary risk in adults from Maracaibo city, Venezuela: A cross sectional study

Abstract

Background: Insulin resistance (IR) is a metabolic disorder related to atherosclerosis. Its measurement is of great importance not only as a marker of diabetes but also for cardiovascular disease. The aim of this research study was to evaluate the relationship between various IR indices and coronary risk in an adult population from Maracaibo city, Venezuela. Methods: The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with random and multi-stage sampling. In this sub study, 1272 individuals of both genders were selected with the measurement of basal insulin and coronary risk according to the Framingham-Wilson formula calibrated for our population. The insulin resistance indices evaluated were HOMA2-IR, triglycerides and glucose index (TyG) and triglycerides/HDL ratio (TG/HDL). The predictive capacity and association between each index and the coronary risk event in 10 years were determined. Results: Of the evaluated population, 55.2% were female, 34.8% had a coronary risk ≥5% in 10 years, with the TG/HDL and TyG indices showing the highest AUC 0.712 (0.681-0.743) and 0.707 (0.675-0.739), respectively; compared to HOMA2-IR. Both were also the indices most associated with increased coronary risk, especially TG/HDL ≥3 with a higher association [OR = 2.83 (1.74-4.61); p<0.01] after multivariable adjustment. Conclusions: TyG (≥4.5) and TG/HDL (≥3) indices showed a great predictive capacity of higher coronary risk, with being TG/HDL more associated even after adjusting for abdominal obesity and hs-CRP. Therefore, these represent useful tools for determining IR.

Correlation Between the Triglyceride–Glucose Index and High Risk of Cardiovascular Disease: A Cohort Study of 102,061 Subjects from Tianjin, China

“…It has been shown that individuals in quartiles with a higher TYG index are more likely to develop atherosclerosis compared to quartiles with a lower TYG index, 21 and studies have also shown an association between increased TyG and cardiovascular disease, 22 , 23 stroke, 24 and atherosclerotic plaque formation events such as coronary artery stenosis. 25 …”

Polarization of Macrophages in Insects: Opening Gates for Immuno-Metabolic Research

“…We may, therefore, presume that antagonism of insulin signaling is the most straightforward strategy to reroute energy flows from maintenance, growth, and reproduction to its fast utilization by the activated immune system. Cytokine-induced deterioration of insulin signaling leads to an increased titer of circulating energy-rich compounds such as glucose, lipoproteins, and amino acids ( Felig et al, 1969 ; Salazar et al, 2018 ; Cho et al, 2019 ). The impact of infection-induced insulin insensitivity on the systemic metabolism highly resembles hyperglycemia and hyperlipidemia as hallmark states of chronic insulin resistance and cachexia ( Khovidhunkit et al, 2004 ; de Luca and Olefsky, 2008 ; Shi et al, 2019 ).…”

Body mass index of schoolchildren under exposure to endogenous and exogenous risk factors (on the example of the republic of Bashkortostan)

“…Следует также отметить, что ИМТ, несмотря на простоту и удобство применения при проведении мониторинговых исследований, обладает рядом существенных недостатков, связанных в первую очередь с отсутствием данных о доле жировой ткани в организме 7 [2]. Крайне важным является комплексный учет факторов риска, ассоциированных с развитием серьезных метаболических и гемодинамических нарушений в организме [30,31]. Особого внимания заслуживает оценка инсулинорезистентности, для чего в настоящее время предлагаются различные индексы: лабораторные (учитывающие показатели инсулина, глюкозы, липидов -например, HOMA-IR, TyG, TG/HDL-C и другие) и комплексные (учитывающие показатели липидного профиля и антропометрические данные -например, LAP, VAI и другие).…”

“…Особого внимания заслуживает оценка инсулинорезистентности, для чего в настоящее время предлагаются различные индексы: лабораторные (учитывающие показатели инсулина, глюкозы, липидов -например, HOMA-IR, TyG, TG/HDL-C и другие) и комплексные (учитывающие показатели липидного профиля и антропометрические данные -например, LAP, VAI и другие). Наиболее перспективными в отношении прогностической оценки кардиометаболического риска представляются лабораторные индексы TyG и TG/HDL-С, что подчеркивает важность включения биохимических исследований в мониторинговые программы для более эффективного управления рисками здоровью населения [30,31].…”