Insulin resistance is associated with an exaggerated blood pressure response to ischemic rhythmic handgrip exercise in nondiabetic older adults

Hotta, Nigishi; Hori, Amane; Okamura, Yukiko; Baba, Reizo; Watanabe, Hidehiro; Sugawara, Jun; Vongpatanasin, Wanpen; Wang, Jijia; Kim, Han-Kyul; Ishizawa, Rie; Iwamoto, Gary A.; Mitchell, Jere H.; Smith, Scott A.; Mizuno, Masaki

doi:10.1152/japplphysiol.00247.2020

Cited by 7 publications

(16 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it is possible that the lower-intensity rhythmic exercise did not produce sufficient metabolic stimuli to unmask a difference in metaboreflex-induced BP responses between groups, notably T2D patients in this study exhibited exaggerated vasoconstriction during PEI. Interestingly, a recent study showed enhanced BP responses to ischemic rhythmic handgrip exercise (30% MVC) in nondiabetic individuals with greater insulin resistance than those with lower insulin resistance (Hotta et al, 2020). Overall, the existing literature supports that both components of the exercise pressor reflex (i.e., mechanoand metabo-reflex) may be enhanced in T2D (Figure 2).…”

Section: Neurovascular Dysregulation During Exercise In Type 2 Diabetesmentioning

confidence: 85%

“…Studies are also needed to further understand the contribution of factors such as insulin resistance, obesity, and physical inactivity. Notably, two studies indicate that insulin resistance may be a stronger predictor of an augmented metaboreflex than obesity in nondiabetic individuals (Milia et al, 2015;Hotta et al, 2020). However, others have demonstrated that obesity may drive negative effects on neural cardiovascular control mechanisms in T2D patients (Holwerda et al, 2016b).…”

Section: Considerations and Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

Neurovascular Dysregulation During Exercise in Type 2 Diabetes

et al. 2021

View full text Add to dashboard Cite

Emerging evidence suggests that type 2 diabetes (T2D) may impair the ability to properly adjust the circulation during exercise with augmented blood pressure (BP) and an attenuated contracting skeletal muscle blood flow (BF) response being reported. This review provides a brief overview of the current understanding of these altered exercise responses in T2D and the potential underlying mechanisms, with an emphasis on the sympathetic nervous system and its regulation during exercise. The research presented support augmented sympathetic activation, heightened BP, reduced skeletal muscle BF, and impairment in the ability to attenuate sympathetically mediated vasoconstriction (i.e., functional sympatholysis) as potential drivers of neurovascular dysregulation during exercise in T2D. Furthermore, emerging evidence supporting a contribution of the exercise pressor reflex and central command is discussed along with proposed future directions for studies in this important area of research.

show abstract

Section: Neurovascular Dysregulation During Exercise In Type 2 Diabetesmentioning

confidence: 85%

Section: Considerations and Future Directionsmentioning

confidence: 99%

Neurovascular Dysregulation During Exercise in Type 2 Diabetes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…PWM and RHG exercise were performed during the 2nd (PEMI + PWM) and the 3rd minute of PEMI (PEMI + RHG), respectively, after a 1 min rest period (PEMI + Rest) which we defined as the second baseline. This protocol was based on a previous study (Hotta et al, 2020 ). Exp.…”

Section: Methodsmentioning

confidence: 99%

“…The intensity of the IHG exercise was set at 30% of the individual's maximum voluntary contraction (MVC) force (Cui et al, 2008 ; Hotta et al, 2020 ; Park et al, 2008 ; Williamson et al, 2002 ), which was determined previously. Participants maintained their gripping force using a visual feedback system.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans

Hasegawa

Hori

Okamura

et al. 2021

Physiological Reports

Self Cite

View full text Add to dashboard Cite

show abstract

Glucose metabolism and autonomic function in healthy individuals and patients with type 2 diabetes mellitus at rest and during exercise

Hamaoka,

Leuenberger,

Drew

et al. 2023

Experimental Physiology

View full text Add to dashboard Cite

Autonomic dysfunction is a common complication of type 2 diabetes mellitus (T2DM). However, the character of dysfunction varies in different reports. Differences in measurement methodology and complications might have influenced the inconsistent results. We sought to evaluate comprehensively the relationship between abnormal glucose metabolism and autonomic function at rest and the response to exercise in healthy individuals and T2DM patients. We hypothesized that both sympathetic and parasympathetic indices would decrease with the progression of abnormal glucose metabolism in individuals with few complications related to high sympathetic tone. Twenty healthy individuals and 11 T2DM patients without clinically evident cardiovascular disease other than controlled hypertension were examined. Resting muscle sympathetic nerve activity (MSNA), heart rate variability, spontaneous cardiovagal baroreflex sensitivity (CBRS), sympathetic baroreflex sensitivity and the MSNA response to handgrip exercise were measured. Resting MSNA was lower in patients with T2DM than in healthy control subjects (P = 0.011). Resting MSNA was negatively correlated with haemoglobin A1c in all subjects (R = −0.45, P = 0.024). The parasympathetic components of heart rate variability and CBRS were negatively correlated with glycaemic/insulin indices in all subjects and even in the control group only (all, P < 0.05). In all subjects, the MSNA response to exercise was positively correlated with fasting blood glucose (R = 0.69, P < 0.001). Resting sympathetic activity and parasympathetic modulation of heart rate were decreased in relationship to abnormal glucose metabolism. Meanwhile, the sympathetic responses to handgrip were preserved in diabetics. The responses were correlated with glucose/insulin parameters throughout diabetic and control subjects. These results suggest the importance of a comprehensive assessment of autonomic function in T2DM.New Findings What is the central question of this study?Are sympathetic and parasympathetic nerves at rest and during exercise equally impaired in type 2 diabetes mellitus? What is the relationship of these dysfunctions to abnormal glucose metabolism? What is the main finding and its importance?Resting sympathetic activity and parasympathetic modulation of heart rate were decreased in relationship to abnormal glucose metabolism. Meanwhile, the sympathetic responses to handgrip were preserved in diabetics. The responses were correlated with glucose/insulin parameters in diabetics and control subjects. These results suggest the importance of a comprehensive assessment of autonomic function in diabetics.

show abstract

Insulin resistance is associated with an exaggerated blood pressure response to ischemic rhythmic handgrip exercise in nondiabetic older adults

Cited by 7 publications

References 54 publications

Neurovascular Dysregulation During Exercise in Type 2 Diabetes

Neurovascular Dysregulation During Exercise in Type 2 Diabetes

Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans

Glucose metabolism and autonomic function in healthy individuals and patients with type 2 diabetes mellitus at rest and during exercise

Contact Info

Product

Resources

About