Insulin Resistance Variability in Women with Anovulatory and Ovulatory Polycystic Ovary Syndrome, and Normal Controls

Cho, L. W.; Kilpatrick, E; Keevil, Brian; Jayagopal, Vijay; Coady, Anne‐Marie; Rigby, Alan S.; Atkin, Stephen L.

doi:10.1055/s-0030-1270450

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…PCOS women were signifi cantly younger, had higher fasting insulin levels, HOMA-IR, ratio total cholesterol-to-HDL (QChol/HDL), testosterone, androstenedione levels and signifi cantly lower SHBG and HDL levels. Median Ferriman-Gallwey score of PCOS women was 7 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) and 52 % of PCOS women were hirsute. Oligo-or amenorrhoea was present in 475 out of 545 PCOS women (87 %) and polycystic ovaries were found in 264 women (48 %).…”

Section: Discussionmentioning

confidence: 99%

Susceptibility Loci for Polycystic Ovary Syndrome on Chromosome 2p16.3, 2p21, and 9q33.3 in a Cohort of Caucasian Women

Lerchbaum¹,

Trummer²,

Giuliani³

et al. 2011

Horm Metab Res

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In a recent genome-wide association study investigating Han Chinese PCOS women 3 loci that are strongly associated with PCOS were identified on chromosome 2p16.3 (rs13405728), 2p21 (rs13429458), and 9q33.3 (rs2479106). The aim of the study was to investigate the impact of rs13405728, rs13429458, and rs2479106 variants on PCOS susceptibility in a Caucasian cohort of PCOS and control women. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed in 545 PCOS and 317 control women. The rs13405728, rs13429458, and rs2479106 polymorphisms were genotyped. There was no significant difference in genotype frequencies of rs13405728 and rs13429458 variants between PCOS and controls. There was a trend towards an association of the rs2479106 variant with PCOS susceptibility (p=0.053). PCOS women with the rs2479106 GG genotype had significantly higher WHR than PCOS women carrying the AG and AA genotype (p=0.034 and p=0.020, respectively). Moreover, QChol/HDL and LDL levels were significantly higher in PCOS women carrying the rs2479106 GG genotype when compared to those carrying the AA genotype (p=0.024 and p=0.035, respectively). PCOS women carrying the G allele of rs13405728 had significantly higher AUCgluc, glucose-30 min, and AUCins levels than those carrying the AA genotype (p=0.039, p=0.047, and p=0.044, respectively). In PCOS women, rs13405728 genotypes are associated with glucose and insulin metabolism. Moreover, rs2479106 genotypes were associated with increased WHR levels and an adverse serum lipid profile. Further, we observed a trend towards decreased PCOS susceptibility within carriers of the rs2479106 G-allele. Further studies in large Caucasian PCOS cohorts are warranted to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Susceptibility Loci for Polycystic Ovary Syndrome on Chromosome 2p16.3, 2p21, and 9q33.3 in a Cohort of Caucasian Women

Lerchbaum¹,

Trummer²,

Giuliani³

et al. 2011

Horm Metab Res

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“…These findings indicated a relationship between PCOS and both development and persistence of IR despite of control of PCOS-induced hormonal disturbances as indicated by being pregnant. In line with these findings, Wang et al (25) found women with a history of recurrent pregnancy loss (RPL) are at an increased risk for IR during the first trimester of a new pregnancy and Cho et al (26) reported that IR and PCOS are coincident events despite of the higher and more variable score in women with anovulatory than women with ovulatory PCOS. Also, Celik et al (27) documented that compared with the control group; patients with RPL were more likely to have IR.…”

Section: Discussion:-mentioning

confidence: 83%

Estimation of Serum Glycodelin A, Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 at 4th Week Gestational Age as Predictors for Early Pregnancy Loss in Pregnant Women With Polycystic Ovary Syndrome.

Sharafeldeen¹

2018

IJAR

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Objectives: To evaluate predictability of estimation of serum levels of glycodelin A (GdA), insulin growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3) at the 4 th week gestation age (GA) for development of early pregnancy loss (EPL) in primigravida with polycystic ovary syndrome (PCOS). Patients & Methods: The study included 45 primigravida PCOS women developed EPL (Study group) and 45 primigravida PCOS women completed the observation period uneventfully (Control group). At the 4 th wk GA, all women underwent clinical examination and pregnancy was assured, then all women gave fasting blood samples for estimation of fasting blood glucose (FBG), serum insulin, GdA, IGF-1 and IGFBP-3. Insulin resistance (IR) was evaluated using the homeostasis model assessment IR (HOMA-IR) score. Results: Study women had significantly higher FBG and HOMA-IR score than control women. Estimated 4-wk GA serum levels of IGF-1 were significantly higher, while serum IGFBP-3 and GdA were significantly lower in study versus control PCOS women. Development of EPL showed positive significant correlation with high FBG, HOMA-IR score and high serum IGF-1 levels, while showed negative significant correlation with serum IGFBP-3 and GdA levels. Statistical analyses defined high serum IGF-1 as significant sensitive predictor, while low serum glycodelin A, IGFBP-1 and FBG as specific predictors for development of EPL, in decreasing order of significance. Conclusion: Low serum GdA and IGFBP-3 levels and high IGF-1 levels estimated at the 4 th wk GA may underlie the development of EPL in pregnant PCOS women. Estimation of three markers as multiple marker panels could predict EPL with high sensitivity and specificity.

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“…It has been shown that IR is present more often in the classic phenotype (80.4%) than in the ovulatory (65.0%) and normoandrogenic (38.1%) [34]. Moreover, it is more frequent in patients with anovulatory compared to those with ovulatory cycles in PCOS [35].…”

Section: The Pathomechanism and Role Of Ir In Pcosmentioning

confidence: 99%

The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome

Bednarz

Kowalczyk

Cwynar

et al. 2022

IJMS

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Insulin resistance is documented in clamp studies in 75% of women with polycystic ovary syndrome (PCOS). Although it is not included in the diagnostic criteria of PCOS, there is a crucial role of this metabolic impairment, which along with hormonal abnormalities, increase each other in a vicious circle of PCOS pathogenesis. Insulin resistance in this group of patients results from defects at the molecular level, including impaired insulin receptor-related signaling pathways enhanced by obesity and its features: Excess visceral fat, chronic inflammation, and reactive oxygen species. While lifestyle intervention has a first-line role in the prevention and management of excess weight in PCOS, the role of anti-obesity pharmacological agents in achieving and maintaining weight loss is being increasingly recognized. Glucagon-like peptide-1 receptor agonists (GLP1-RAs) not only act by reducing body weight but also can affect the mechanisms involved in insulin resistance, like an increasing expression of glucose transporters in insulin-dependent tissues, decreasing inflammation, reducing oxidative stress, and modulating lipid metabolism. They also tend to improve fertility either by increasing LH surge in hypothalamus-pituitary inhibition due to estrogen excess connected with obesity or decreasing too high LH levels accompanying hyperinsulinemia. GLP1-RAs seem promising for effective treatment of obese PCOS patients, acting on one of the primary causes of PCOS at the molecular level.

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Insulin Resistance Variability in Women with Anovulatory and Ovulatory Polycystic Ovary Syndrome, and Normal Controls

Cited by 12 publications

References 29 publications

Susceptibility Loci for Polycystic Ovary Syndrome on Chromosome 2p16.3, 2p21, and 9q33.3 in a Cohort of Caucasian Women

Susceptibility Loci for Polycystic Ovary Syndrome on Chromosome 2p16.3, 2p21, and 9q33.3 in a Cohort of Caucasian Women

Estimation of Serum Glycodelin A, Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 at 4th Week Gestational Age as Predictors for Early Pregnancy Loss in Pregnant Women With Polycystic Ovary Syndrome.

The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome

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