Insulin resistance with impaired fasting glucose increases the risk of NAFLD

Önnerhag, Kristina; Nilsson, Peter M.; Lindgren, Stefan

doi:10.4236/ojgas.2013.33028

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…The decrease in the levels of serum total protein and albumin in NAFLD rats group may be due to the elevation in the breakdown of SH-bond, disturbance in the endoplasmic reticulum (ER) function, increment in the deamination of amino acid or/and decrease in the activity of AST and ALT in the hepatic cells. These data are in harmony with several recent investigations that reported a significant increase in lipid peroxidation and reduction of hepatic antioxidant enzyme activities in rats fed high fructose diet (Onnerhag et al, 2013;Brumbaughff &Friedmanff, 2014 andSookoian &Pirola, 2014).…”

Section: -7 -supporting

confidence: 92%

“…Both hepatic and systemic insulin resistances are strongly associated with NAFLD. In a fatty liver the ability of insulin to inhibit hepatic glucose production is impaired leading to hyperglycemia and further insulin resistance (Tilg &Moschen, 2008 andOnnerhag et al, 2013). There is no world-wide standardized cut-off level for HOMA-IR in diagnosing insulin resistance and the insulin assay differs between countries.…”

Section: Resultsmentioning

confidence: 99%

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Therapeutic Roles of Silymarin or/and Taurine on Nonalcoholic Fatty Liver Disease Associated with Metabolic Syndrome in Rats

Zahran

Shahin

Kelada

et al. 2015

Journal of Scientific Research in Science

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Non-alcoholic fatty liver disease (NAFLD) represents one of the most common liver diseases. It is strongly associated with obesity and insulin resistance and thought to be parameters of the metabolic syndrome. NAFLD can progress to non-alcoholic steatohepatitis then to cirrhosis and liver failure. This study aimed to investigate whether silymarin or/and taurine can improve non-alcoholic fatty liver in an animal model and whether this therapeutic approach can result amelioration in carbohydrates profile (serum glucose, insulin, insulin resistance index and hepatic glycogen), lipids profile (serum cholesterol, triglycerides, free fatty acids, leptin and adiponectin as well as hepatic total lipids & cholesterol), liver function profile (serum aspartate transaminase, alanine transaminase, total protein, albumin and haptoglobin) and the cytokines profile (serum tumor necrosis factor-α, interleukin-1ß and interleukin-6). The obtained results revealed a significant (p<0.001) increase in carbohydrates profile (glucose, insulin, insulin resistance index & hepatic glycogen) in NAFLD rats than those in their control ones. Similary, lipid parameters (serum cholesterol, triglycerides, free fatty acids and leptin as well as hepatic total lipids & cholesterol) and liver function tests (serum aspartate transaminase, alanine transaminase and haptoglobin)were significantly (p<0.001) elevated in NAFLD rats compared with their corresponding control group. On the other hand, induction of NAFLD to rats caused a significant (p<0.001) decrease in adiponectin level with a remarkable decrease in serum total protein and albumin. A considerable (p<0.001) elevation were occurred in all cytokines parameters (serum tumor necrosis factor-α, interleukin-1ß and interleukin-6) in NAFLD rats group compared with their corresponding control group. When, NAFLD rats group was treated with silymarin or/and taurine, a considerable amelioration effects in all previous studied parameters were pronounced dependent on certain mechanisms and time of treatment. In conclusion, silymarin or/and taurine reduced metabolic abnormalities associated with NAFLD via inhibition the oxidative stress, increment in the stabilization of mitochondrial membrane, reduction the lipid accumulation in the liver, enhancement in the endoplasmic reticulum (ER) and improving insulin resistance. Overall, silymarin and taurine may be considered as promising and novel therapies for the treatment of NAFLD.

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Section: -7 -supporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Therapeutic Roles of Silymarin or/and Taurine on Nonalcoholic Fatty Liver Disease Associated with Metabolic Syndrome in Rats

Zahran

Shahin

Kelada

et al. 2015

Journal of Scientific Research in Science

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“…In an insulin-resistant state, the incapability of insulin to inhibit lipolysis leads to raised fluctuation of free fatty acids to the liver from adipose tissue. Enlarged de novo lipogenesis and augmented consumption of dietary fat contribute to the development of NAFLD 38. Li et al 15.…”

Section: Discussionmentioning

confidence: 99%

“…Enlarged de novo lipogenesis and augmented consumption of dietary fat contribute to the development of NAFLD. 38 Li et al . 15 found that IL-18 was significantly higher in NAFLD patients than in controls, while Vecchiet et al .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease

Borai¹,

Shaker²,

Kamal³

et al. 2017

Journal of Clinical and Translational Hepatology

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Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is a silent disease; its spectrum includes simple steatosis, nonalcoholic steatohepatitis and fibrosis. Pro- and anti-inflammatory cytokines play roles in the pathogenesis of NAFLD and insulin resistance (IR). Moreover, plasma cell antigen-1 (PC-1) is related to IR and associated with NAFLD progression. Therefore, we aimed to detect biomarkers, ultrasonographic and anthropometric findings capable of differentiating NAFLD grades, since most previous investigators were concerned more with NAFLD patients without classifying them into grades.Methods: A total of 87 NAFLD patients (31 with grade 1 (mild NAFLD), 26 with grade 2 (moderate NAFLD) and 30 with grade 3 (severe NAFLD) were included in the study, in addition to 47 controls (grade 0). All subjects underwent ultrasonographic examination for NAFLD diagnosis. Serum interleukin-10 (IL-10), plasma interleukin-18 (IL-18) and plasma PC-1 levels were determined using enzyme-linked immunosorbent assay.Results: Homoeostasis model assessment (HOMA)-IR was higher in different NAFLD grades than in controls. Ultrasonographic and anthropometric findings and lipid profile indices (except for high-density lipoprotein cholesterol, which was decreased) were increased with NAFLD progression. Grade 3 patients showed significant increase in levels of IL-18 and significant decrease in IL-10 and PC-1 levels when compared to grade 1 patients.Conclusion: Anthropometric and ultrasonographic findings were valuable in differentiating NAFLD grades. IR is very important in NAFLD pathogenesis. IL-18, HOMA-index and PC-1 levels could be used to differentiate between NAFLD grades, together with other measurements.

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“…Onnerhag, Nilsson & Lindgren [21] analyzed the association between insulin resistance and NAFLD and found interesting results. Liver steatosis showed significantly correlation with ALT (alanine aminotransferase), HOMA-IR and the metabolic syndrome and 80% of the subjects with NAFLD had either developed type 2 diabetes mellitus or other impaired fasting glucose.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Physical Activity Level, Hepatic Steatosis Presence, Metabolic Syndrome and the Risk of Developing Type 2 Diabetes in Men

Montenegro¹,

Marega²,

Carvalho³

et al. 2016

Health

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Cardiovascular disease, cancer, respiratory and metabolic disease represent 63% of all deaths worldwide and are considered the major causes of morbidity and mortality. Physical inactivity is considered a case of public health, and other behavioral and metabolic risk factors, according to WHO (2011), such as smoking, increased blood pressure, increased blood glucose, hypercholesterolemia, overweight and obesity. The Nonalcoholic Fatty Liver Disease (NAFLD) is the most prevalent liver disease in adults, and can progress and be characterized as hepatic steatosis (HS) which is derived from the accumulation of lipids in hepatocytes, and histopathologic condition is more than 5% of the weight of liver. So, the purpose of this study is to identify the relationship between the physical activity level and the hepatic steatosis presence, metabolic syndrome and the risk of developing type 2 diabetes mellitus in men. We evaluated retrospectively medical records of 1399 men (40.7 ± 8.18 years old) who participated in the protocol of Preventive Health Check-up at Hospital Israelita Albert Einstein from January to October 2011. According to the results, it is concluded that there is a positive association between low physical activity level and the presence of Hepatic steatosis. The results further demonstrate that, despite the high BMI, blood levels of the subjects remained unchanged. Even without a positive association between these variables, the results showed a high risk behavior for the development of diabetes mellitus type 2.

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Insulin resistance with impaired fasting glucose increases the risk of NAFLD

Cited by 5 publications

References 30 publications

Therapeutic Roles of Silymarin or/and Taurine on Nonalcoholic Fatty Liver Disease Associated with Metabolic Syndrome in Rats

Therapeutic Roles of Silymarin or/and Taurine on Nonalcoholic Fatty Liver Disease Associated with Metabolic Syndrome in Rats

Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease

Relationship between Physical Activity Level, Hepatic Steatosis Presence, Metabolic Syndrome and the Risk of Developing Type 2 Diabetes in Men

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