Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9

Hernández, Marta; Molló, Àngels; Marsal, Josep Ramón; Esquerda, Aureli; Capel, Ismael; Puig-Domingo, Manel; Pozzilli, Paolo; Leiva, Alberto de; Mauricio, Dı́dac

doi:10.1186/1472-6823-15-1

Cited by 72 publications

(72 citation statements)

References 15 publications

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“…In a country like Nepal, where diabetes imposes a huge financial burden on patients [34], and where diabetes management is challenged by poor health literacy [35] and patients’ limited knowledge of diabetes [18,36], the extent to which self-monitoring should be promoted and to what extent the benefits of self-monitoring may be achieved (and how) should be carefully considered. It is also important to have a realistic expectation of how self-monitoring practices might be implemented effectively.…”

Section: Discussionmentioning

confidence: 99%

Blood glucose monitoring in type 2 diabetes – Nepalese patients’ opinions and experiences

Sapkota

Brien

Aslani

2017

Global Health Action

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Background: Blood glucose monitoring forms a vital component of diabetes care. Monitoring conducted at home using glucometers, and in laboratories by professionals, are two common methods of blood glucose monitoring in clinical practice. Objective: To investigate Nepalese patients’ perceptions and practices of blood glucose monitoring in diabetes. Methods: In-depth interviews were conducted with 48 Nepalese participants with type 2 diabetes in Sydney and Kathmandu. The interviews were audio-recorded, transcribed verbatim and thematically analysed. Results: In Australia, most participants perceived home monitoring as useful; and both home and laboratory monitoring were conducted at fairly regular intervals. In Nepal, only a small number conducted home monitoring and the laboratory method formed the primary method of day-to-day monitoring. The laboratory method was preferred due to easy access to laboratories, lack of faith in glucometers and perceptions that home monitoring is costlier. However, overall monitoring was irregular in Nepal. In addition to the healthcare system which enabled cheaper self-monitoring in Australia, Nepalese in Australia also tended to have a better understanding about the purpose of home monitoring. Conclusions: This study has highlighted the disparity in perceptions and practices related to blood glucose monitoring. Understanding the importance of blood glucose monitoring and access to affordable resources are critical facilitators for conducting regular monitoring. Both patient and health-system factors play a key role in ensuring continued diabetes monitoring and management.

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Section: Discussionmentioning

confidence: 99%

Blood glucose monitoring in type 2 diabetes – Nepalese patients’ opinions and experiences

Sapkota

Brien

Aslani

2017

Global Health Action

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“…However, pituitary infiltration was suspected after she was hospitalized, and hypotension, polyuria and polydipsia were documented. Another additional rare manifestation is anasarca due to hypothyroidism (1). …”

Section: Discussionmentioning

confidence: 99%

“…NHL infiltration of posterior pituitary gland also causes loss of the posterior hyper-intensity on MRI. However, majority of cases also reported a heterogeneous mass infiltration of the adenohypophysis with parasellar extension (1, 2, 3, 4). This case presented increment in pituitary size that reduced after chemotherapy (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Infundibulo-hypophysitis-like radiological image in a patient with pituitary infiltration of a diffuse large B-cell non-Hodgkin lymphoma

León‐Suárez

Roldán-Sarmiento

Gómez-Sámano

et al. 2016

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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SummaryNon-Hodgkin lymphoma (NHL) is a hematological tumor caused by abnormal lymphoid proliferation. NHL can arise in any part of the body, including central nervous system (CNS). However, pituitary involvement is a quite rare presentation. The diffuse large B-cell lymphoma (DLBCL) is the most common subtype when pituitary is infiltrated. Here, we report a case of pituitary infiltration of NHL DLBCL type in a woman with hypopituitarism and an infundibulum-hypophysitis-like image on magnetic resonance imaging (MRI). A female aged 64 years, complained of dyspepsia, fatigue, weight loss and urine volume increment with thirst. Endoscopy and gastric biopsy confirmed diffuse large B-cell lymphoma. Treatment with chemotherapy using R-CHOP was initiated. During her hospitalization, hypotension and polyuria were confirmed. Hormonal evaluation was compatible with central diabetes insipidus and hypopituitarism. Simple T1 sequence of MRI showed thickening of the infundibular stalk with homogeneous enhancement. After lumbar puncture analysis, CNS infiltration was confirmed showing positive atypical lymphocytes. Pituitary and infundibular stalk size normalized after R-CHOP chemotherapy treatment. In conclusion, pituitary infiltration of NHL with infundibular-hypophysitis-like image on MRI is a rare finding. Clinical picture included hypopituitarism and central diabetes insipidus. Diagnosis should be suspected after biochemical analysis and MRI results. Treatment consists of chemotherapy against NHL and hormonal replacement for pituitary dysfunction.Learning points:Pituitary infiltration by lymphoma can present with signs and symptoms of panhypopituitarism and diabetes insipidus.MRI findings can resemble an autoimmune hypophysitis.Patients can recover pituitary function as well as normalization of MRI after chemotherapy treatment.

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“…Type 1 diabetes is divided into two subtypes (classical type 1 diabetes and LADA) [14, 15]. The present study of histone methylation in type 1 diabetes patients focused on classical type 1 diabetes, rarely in LADA.…”

Section: Introductionmentioning

confidence: 99%

Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C

Liu

2017

Journal of Diabetes Research

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Aims. Latent autoimmune diabetes in adults (LADA) is an autoimmune disease of which the mechanism is not clear. Emerging evidence suggests that histone methylation contributes to autoimmunity. Methods. Blood CD4+ T lymphocytes from 26 LADA patients and 26 healthy controls were isolated to detect histone H3 lysine 4 and H3 lysine 9 methylation status. Results. Reduced global H3 lysine 9 methylation was observed in LADA patients' CD4+ T lymphocytes, compared to healthy controls (P < 0.05). H3 lysine 4 methylation was not statistically different. The reduced H3 lysine 9 methylation was associated with GADA titer but not correlated with glycosylated hemoglobin (HbA1c). When the LADA patient group was divided into those with complication and those without, relatively reduced global H3 lysine 9 methylation was observed in LADA patients with complication (P < 0.05). The expression of histone methyltransferase SUV39H2 for H3 lysine 9 methylation was downregulated in LADA patients, and the expression of histone demethylase KDM4C which made H3 lysine 9 demethylation was upregulated. Conclusion. The reduction of histone H3 lysine 9 methylation which may due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C was found in CD4+ T lymphocytes of LADA patients.

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Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9

Cited by 72 publications

References 15 publications

Blood glucose monitoring in type 2 diabetes – Nepalese patients’ opinions and experiences

Blood glucose monitoring in type 2 diabetes – Nepalese patients’ opinions and experiences

Infundibulo-hypophysitis-like radiological image in a patient with pituitary infiltration of a diffuse large B-cell non-Hodgkin lymphoma

Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C

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