Insulin Secretion Induced by Allogeneic Lymphocytes

Jb, Garcia; Mc, Venturino; Jc, Basabe

doi:10.1055/s-2007-1011849

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1989

1990

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“…Several authors have found that animals injected with antigens alter plasma insulin levels (Gabrilovac, Pavelic, Marusic, Orsanik, Suchanek and Pavelic 1982). Incubated mice pancreas showed an enhanced insulin response to antigenic stimulation (Garcia, Venturini and Basabe 1987). These studies aimed to clarify the processes responsible for the destruction of islet B cells (insulitis).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Insulin Secretion by Rat Mesenteric Lymphocytes in Incubated Pancreatic Islet Cells

Curi

Ms²,

Mg³

et al. 1990

Horm Metab Res

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Section: Introductionmentioning

confidence: 99%

Inhibition of Insulin Secretion by Rat Mesenteric Lymphocytes in Incubated Pancreatic Islet Cells

Curi

Ms²,

Mg³

et al. 1990

Horm Metab Res

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Insulin secretion induced by alloantigens. Mechanisms of action

et al. 1989

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Basal insulin secretion stimulated by allogeneic lymphocyte injection was inhibited by SRIF, diazoxide and verapamil but was not affected by theophylline or imidazole. Glucose stimulated insulin secretion induced by alloantigens was inhibited by imidazole. Maximum insulin secretion was achieved with 2.1 mg/ml theophylline in allogeneized mouse pancreata and with 4.2 mg/ml in control pancreata. Propranolol also blocked allogen-induced glucose-stimulated insulin secretion. Phentolamine enhanced insulin secretion from both experimental groups, but phentolamine plus epinephrine only stimulated insulin secretion in control pancreata. Verapamil, diazoxide and SRIF diminished insulin secretion in both experimental groups. These results suggest that: a) basal insulin secretion induced by alloantigens may be mediated by an increase in calcium translocation, and b) glucose-stimulated insulin secretion induced by alloantigen may be mediated by a rise in B-cell cAMP.

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Insulin Secretion Induced by Allogeneic Lymphocytes

Cited by 2 publications

References 6 publications

Inhibition of Insulin Secretion by Rat Mesenteric Lymphocytes in Incubated Pancreatic Islet Cells

Inhibition of Insulin Secretion by Rat Mesenteric Lymphocytes in Incubated Pancreatic Islet Cells

Insulin secretion induced by alloantigens. Mechanisms of action

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