Insulin sensitivity: Gender-related differences in subjects with normal glucose tolerance

Schianca, Gian Piero Carnevale; Castello, Luigi Mario; Rapetti, Rachele; Limoncini, A.; Bartoli, Ettore

doi:10.1016/j.numecd.2005.05.004

Cited by 15 publications

(9 citation statements)

References 33 publications

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“…It is also firmly established that IS, some cardiovascular risk factors, and carotid IMT exhibit definite sex-related differences. 24,25 In our healthy men, in particular in overweight and obese men, lower IS was associated with higher baseline CCA-IMT independently of established risk factors. However, the association between CCA-IMT and M/I was eliminated on introducing FFA and the leptin:adiponectin ratio into the prediction model.…”

Section: Discussionmentioning

confidence: 71%

Insulin Sensitivity and Carotid Intima-Media Thickness

Kozàkovà

Natali

Dekker

et al. 2013

ATVB

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Objective— Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results— We studied a European cohort of 525 men and 655 women (mean age, 44±8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intima-media thickness in the common carotid artery (CCA-IMT) was significantly higher ( P <0.05) in the lowest M/I tertile, whereas in women CCA-IMT was higher ( P <0.0005) in the highest fasting plasma glucose tertile (after adjustment for established risk factors). In multiple regression models, with CCA-IMT as the dependent variable and with risk factors and univariate metabolic correlates as independent variables, circulating free fatty acids and the leptin:adiponectin ratio replaced M/I as independent metabolic determinants of CCA-IMT in men. The strongest metabolic determinant of CCA-IMT in women was fasting plasma glucose. Three-year CCA-IMT changes were not associated with any cardio-metabolic risk factor. Conclusions— In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose.

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Section: Discussionmentioning

confidence: 71%

Insulin Sensitivity and Carotid Intima-Media Thickness

Kozàkovà

Natali

Dekker

et al. 2013

ATVB

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“…Some reports showed a difference between men and women in the elevation of FPG [24][25][26], and another showed similar results between men and women in the elevation of FPG [27]. We analyzed the results from our 158 female subjects, and we could not find remarkable differences with male subjects (data not shown).…”

Section: Discussionmentioning

confidence: 82%

Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men

et al. 2008

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“…Independent, but related, changes in insulin sensitivity also occur during puberty and perimenopause, with studies showing that females are more insulin resistant than males throughout both reproductive transitions (Goran & Gower, 2001; Moran et al, 1999; Schianca, Castello, Rapettie, LImoncini, & Bartoli, 2006; Wildman et al, 2008). While insulin resistance appears to play an integral role in healthy somatic growth at the beginning of puberty (likely driven by both growth hormones and sex steroids), continued insulin resistance later in puberty could lead to unhealthy weight gain and put youth at increased risk for type 2 diabetes during adolescence and for cardiovascular disease (CVD) later in life (Goran & Gower, 2001).…”

Section: Resultsmentioning

confidence: 99%

“…While insulin resistance appears to play an integral role in healthy somatic growth at the beginning of puberty (likely driven by both growth hormones and sex steroids), continued insulin resistance later in puberty could lead to unhealthy weight gain and put youth at increased risk for type 2 diabetes during adolescence and for cardiovascular disease (CVD) later in life (Goran & Gower, 2001). Likewise, changes in body fat distribution and insulin resistance during perimenopause are associated with increased risk for CVD (Matthews et al, 1989; Schianca et al, 2006). …”

Section: Resultsmentioning

confidence: 99%

“…Other evidence, however, suggests that women’s increased vulnerability to developing CVD during the menopausal transition may be due to factors independent of weight gain or changes in insulin homeostasis (Schianca et al, 2006). For example, one study has shown that the thickness and diameter of the carotid artery changes during perimenopause, which increase women’s vulnerability to developing CVD (El Khoudary et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Puberty and perimenopause: Reproductive transitions and their implications for women's health

Hoyt

Falconi

2015

Social Science & Medicine

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This scoping review synthesizes existing research on two major transitions in females’ lives: puberty and perimenopause. These two periods of vast physiological change demarcate the beginning and the end of the reproductive life cycle and are associated with major neuroendocrine reorganization across two key systems, the hypothalamic-pituitary-gonadal (HPG) axis the hypothalamus-pituitary-adrenal (HPA) axis. Despite growing evidence suggesting that the timing and experience of puberty and perimenopause are related to various physical and mental health outcomes (e.g., mood disorders, metabolism, cardiovascular health, autoimmune conditions and cancer), these two processes are rarely examined together. In this paper, we bridge these disparate literatures to highlight similarities, isolate inconsistencies, and identify important areas for future research in women’s health.

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Insulin sensitivity: Gender-related differences in subjects with normal glucose tolerance

Cited by 15 publications

References 33 publications

Insulin Sensitivity and Carotid Intima-Media Thickness

Insulin Sensitivity and Carotid Intima-Media Thickness

Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men

Puberty and perimenopause: Reproductive transitions and their implications for women's health

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