Insulin sensitivity with respect to glucose metabolism in hypertension-prone men did not predict the blood pressure increase in 5 years

Mattiasson, Ingrid; Endre, T; Hulthén, U L

doi:10.1038/sj.jhh.1001272

Cited by 4 publications

(10 citation statements)

References 21 publications

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“…Only 2 previous investigations into the longitudinal relationship between insulin sensitivity and BP in adults have incorporated direct measures of insulin sensitivity, 20,29 and only 1 investigation used the euglycemic clamp. One of these studies was relatively small (n=54) and in men only: no effect was demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…One of these studies was relatively small (n=54) and in men only: no effect was demonstrated. 29 The other used a modified frequently sampled intravenous glucose tolerance test in a triethnic population (n=840) and reported a modest protective association of insulin sensitivity on the risk of hypertension. 20 Other longitudinal studies reporting a relationship between insulin sensitivity and BP [10][11][12][13][14][15][16][17][18][19][20][21][22] have been based on surrogate measures of insulin resistance, including either fasting insulin [10][11][12][13][14][15]17,21,22 or fasting insulin and glucose concentrations (HOMA).…”

Section: Discussionmentioning

confidence: 99%

“…20 Other longitudinal studies reporting a relationship between insulin sensitivity and BP [10][11][12][13][14][15][16][17][18][19][20][21][22] have been based on surrogate measures of insulin resistance, including either fasting insulin [10][11][12][13][14][15]17,21,22 or fasting insulin and glucose concentrations (HOMA). 18,19 They have been performed in a variety of populations (Scandinavian 11,15,22 ; Mexican-American 16,17 ; Japanese individuals 13,14 ), with some including only men 10,11,19,25,29 but none only women. Some studies of reasonable size and duration have reported no relationship between insulin sensitivity and BP 9,23,24,26,27 after adjustment for baseline BP and weight/adiposity, although it is difficult to interpret from some studies whether data were examined separately by sex.…”

Section: Discussionmentioning

confidence: 99%

“…Some previous studies in adults have used more direct physiological methods but have been either small 29 or cross-sectional. 30,31 Having previously published cross-sectional euglycemic clamp data from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort (n=1384), 32 we now report the longitudinal relationship between baseline insulin sensitivity and BP during 3 years.…”

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Euglycemic Clamp Insulin Sensitivity and Longitudinal Systolic Blood Pressure

Petrie

Malik²,

Balkau³

et al. 2013

Hypertension

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Abstract-Insulin resistance may be an independent risk factor for the development of hypertension, but change in blood pressure (BP) over time has not been adequately studied in healthy individuals fully characterized for insulin sensitivity.In the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study, we measured insulin sensitivity (M/I) using the euglycemic clamp technique in 1073 healthy European adults (587 women, 486 men) aged 30 to 60 years followed up 3 years later. Systolic BP (SBP) at baseline was higher in insulin-resistant women (ie, those in the low sex-specific M/I tertile) compared with those in the intermediate (P<0.001) or high tertiles (P=0.06; mean±SD: 117±13, 111±12, 114±12 mm Hg, respectively). It did not differ across M/I tertiles in men. After adjustment for age, body mass index, baseline SBP, and other covariates, low insulin sensitivity (M/I) predicted a longitudinal rise in SBP in women but not in men; M/I was not associated with change in diastolic BP. SBP rose over time in both sexes and within all M/I tertiles (P<0.05), except in women with high insulin sensitivity. Therefore, in women (but not in men), low insulin sensitivity was associated with higher SBP at 3 years, and high insulin sensitivity was associated with a lower rise in SBP BP and Physical ExaminationBP was measured sitting after 5-minute rest by trained study nurses (OMRON 705CP, Hamburg, Germany) in triplicate, according to a standard protocol: the median of these readings was used in this analysis. Median systolic BP (SBP) ≥140 mm Hg and median diastolic BP (DBP) ≥90 mm Hg at follow-up were taken to indicate hypertension. 34,35 Participants who had been identified and commenced on treatment in routine care (n=46) were classified as hypertensive. Height was measured by stadiometer. Body weight, percentage of body fat, and lean body mass (lbm) were evaluated by bioimpedance (TBF-300, Tanita International Division, United Kingdom). Insulin SensitivityInsulin sensitivity was measured by a standard hyperinsulinemic euglycemic clamp technique as previously described, after central training of site staff.33 Target plasma glucose concentration was between 4.5 and 5.5 mmol/L; insulin was infused at a rate of 240 pmol·min. Plasma glucose was measured at 5-to 10-minute intervals to ensure it remained within 0.8 mmol/L (±15%) of target glucose concentration. The steady-state period (for calculation of insulin sensitivity) was between 80 and 120 minutes. The glucose infusion rate (M value) was expressed in mg·min Biological SamplesTotal cholesterol, high-density lipoprotein cholesterol, and triglycerides were assayed by enzymatic colorimetric assay (Roche), and low-density lipoprotein cholesterol was calculated by the Friedewald formula. A 75-g oral glucose tolerance test was used to exclude participants with diabetes mellitus at inclusion (or developing diabetes mellitus during follow-up), with glucose assayed centrally by the glucose oxidase method (Cobas Integra, Roche). Other MeasuresPhysical acti...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Euglycemic Clamp Insulin Sensitivity and Longitudinal Systolic Blood Pressure

Petrie

Malik²,

Balkau³

et al. 2013

Hypertension

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Insulin Resistance and Risk of Incident Hypertension Among Men

Lai

Curhan

Forman

2009

J of Clinical Hypertension

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The independent association between insulin resistance and the development of hypertension remains in doubt because insulin resistance correlates with other metabolic factors also proposed to be associated with hypertension. The authors examined the association between the insulin sensitivity index and incident hypertension in a prospective nested case-control study among 1453 men (mean age, 61 years) who participated in the Health Professionals' Follow-up Study. The authors computed the insulin sensitivity index for each man in the study based on fasting insulin and triglyceride levels. Logistic regression was performed conditioned on age and adjusted for standard hypertension risk factors as well as renal function, cholesterol, and uric acid. The insulin sensitivity index was 6% lower in the cases compared with the controls (P<.001). The multivariable odds ratio for hypertension comparing the lowest with highest quartile of insulin sensitivity index was 1.09 (0.71-1.65) among the entire sample. However, the association between the insulin sensitivity index and incident hypertension differed significantly by age (P interaction <.001). Among men younger than 60 years, the multivariable odds ratio for the lowest compared with highest quartile was 1.93 (1.01-3.71) but was 0.67 (0.37-1.24) among older men. Insulin resistance is independently associated with incident hypertension among younger men.

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Relations of Insulin Sensitivity to Longitudinal Blood Pressure Tracking

Ärnlöv

Pencina²,

Nam³

et al. 2005

Circulation

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Background-The relations of insulin sensitivity (IS) to hypertension incidence may vary according to baseline age, body mass index (BMI), and blood pressure (BP . On follow-up, 41% of participants had BP progression (Ն1 BP stage increase) and 18% had development of hypertension (systolic BPՆ140 or diastolic BPՆ90 mm Hg or antihypertensive medication use). In younger (Ͻ51 years) people with normal BMI and baseline BPϽ130/85 mm Hg, the second-to-fourth ISI 0,120 quartiles were associated with lower multivariable-adjusted odds for hypertension incidence (0.27; 95% CI, 0.09 to 0.83; PϽ0.05) and BP progression (0.37; 95% CI, 0.18 to 0.77; PϽ0.01) relative to the lowest (most insulin resistant) quartile. IS was not related to BP progression or hypertension incidence in older individuals, in obese participants, or in people with BPՆ130/85 mm Hg. Conclusions-In our large community-based sample, reduced IS predicted BP tracking principally in younger people with normal BMI and BPϽ130/85 mm Hg. Effect modification by age, BMI, and baseline BP may explain variation in the results of prior clinical investigations relating IS to hypertension incidence.

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Insulin sensitivity with respect to glucose metabolism in hypertension-prone men did not predict the blood pressure increase in 5 years

Cited by 4 publications

References 21 publications

Euglycemic Clamp Insulin Sensitivity and Longitudinal Systolic Blood Pressure

Euglycemic Clamp Insulin Sensitivity and Longitudinal Systolic Blood Pressure

Insulin Resistance and Risk of Incident Hypertension Among Men

Relations of Insulin Sensitivity to Longitudinal Blood Pressure Tracking

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