Insulin-Stimulated Glucose Disposal Is not Increased in Anorexia Nervosa*

Castillo, Manuel J.; Scheen, André; Lefèbvre, Pierre; Luyckx, A

doi:10.1210/jcem-60-2-311

Cited by 49 publications

(14 citation statements)

References 14 publications

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“…Lipid concentrations were comparable across plasma and serum, although, different laboratory methods were used. In the nine studies with unpecified diagnostic criteria (Blickle et al, 1984;Castillo et al, 1985;Crisp et al, 1968;Miyai et al, 1975;Mordasini et al, 1977;Nestel, 1974;Rigaud, 1999;Stephan et al, 1977;Uhe et al, 1992), the study participants had low BMIs (<16.3 kg/m 2 ), low percentage of ideal body weight (<73.8%), confirmation of the AN diagnosis by psychiatric examination, history of food aversion, secondary amenorrhea, and/or rapid (Umeki, 1988) In the nine studies with unpecified diagnostic criteria (Blickle et al, 1984;Castillo et al, 1985;Crisp et al, 1968;Miyai et al, 1975;Mordasini et al, 1977;Nestel, 1974;Rigaud, 1999;Stephan et al, 1977;Uhe et al, 1992), the study participants had low BMIs (<16.3 kg/m 2 ), low percentage of ideal body weight (<73.8%), confirmation of the AN diagnosis by psychiatric examination, history of food aversion, secondary amenorrhea, and/or rapid (Umeki, 1988) …”

Section: Resultsmentioning

confidence: 99%

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Increased lipid and lipoprotein concentrations in anorexia nervosa: A systematic review and meta‐analysis

Hussain

Hübel

Hindborg

et al. 2019

Intl J Eating Disorders

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Objective: Alterations in blood lipid concentrations in anorexia nervosa (AN) have been reported; however, the extent, mechanism, and normalization with weight restoration remain unknown. We conducted a systematic review and a meta-analysis to evaluate changes in lipid concentrations in acutely-ill AN patients compared with healthy controls (HC) and to examine the effect of partial weight restoration. Method: A systematic literature review and meta-analysis (PROSPERO: CRD42017078014) were conducted for original peer-reviewed articles. Results: Forty-eight studies were eligible for review; 33 for meta-analyses calculating mean differences (MD). Total cholesterol (MD = 22.7 mg/dL, 95% CI = 12.5, 33.0), high-density lipoprotein (HDL; MD = 3.4 mg/dL, CI = 0.3, 7.0), low-density lipoprotein (LDL; MD = 12.2 mg/dL, CI = 4.4, 20.1), triglycerides (TG; MD = 8.1 mg/dL, CI = 1.7, 14.5), and apolipoprotein B (Apo B; MD = 11.8 mg/dL, CI = 2.3, 21.2) were significantly higher in acutely-ill AN than HC. Partially weight-restored AN patients had higher total cholesterol (MD = 14.8 mg/dL, CI = 2.1, 27.5) and LDL (MD = 16.1 mg/dL, CI = 2.3, 30.0). Pre-versus post-weight restoration differences in lipid concentrations did not differ significantly. Discussion: We report aggregate evidence for elevated lipid concentrations in acutely-ill AN patients compared with HC, some of which persist after partial weight restoration. This could signal an underlying adaptation or dysregulation not fully reversed by weight restoration. Although concentrations differed between AN and HC, most lipid concentrations remained within the reference range and metaanalyses were limited by the number of available studies. ResumenObjetivo: En la anorexia nervosa (AN) han sido reportadas alteraciones en las concentraciones de lípidos sanguíneos; sin embargo, la extensión, mecanismo y normalización con la restauración del peso continúa aún desconocida. Hicimos una revisión sistemática y meta-análisis para evaluar los cambios en las concentraciones de lípidos

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Section: Resultsmentioning

confidence: 99%

“…BMI was calculated from average weight and height (Castillo, Scheen, Lefebvre, & Luyckx, 1985;Mordasini, Klose, Heuck, Augustin, & Greten, 1977). BMI was calculated from average weight and height (Castillo, Scheen, Lefebvre, & Luyckx, 1985;Mordasini, Klose, Heuck, Augustin, & Greten, 1977).…”

Section: Meta-analysismentioning

confidence: 99%

Increased lipid and lipoprotein concentrations in anorexia nervosa: A systematic review and meta‐analysis

Hussain

Hübel

Hindborg

et al. 2019

Intl J Eating Disorders

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“…In particular, insulin-stimulated glucose disposal has been reported to be normal (29), enhanced (30,31), or decreased (32) in AN subjects. In our study, we found a reduced insulin-stimulated glucose disposal in the AN group, with prevalent impairment of nonoxidative glucose metabolism and no difference in glucose oxidation, thus suggesting that insulin stimulates glucose oxidation more than glucose storage in AN patients.…”

Section: Discussionmentioning

confidence: 99%

Anorexia Nervosa Is Characterized by Increased Adiponectin Plasma Levels and Reduced Nonoxidative Glucose Metabolism

Pannacciulli

Vettor

Milan

et al. 2003

The Journal of Clinical Endocrinology &Amp; Metabolism

152

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The aim of the present study was to examine the effects of anorexia nervosa (AN) on adipocytokines (leptin and adiponectin) plasma concentrations and insulin-stimulated glucose disposal in adolescent and young adult women. Adiponectin and leptin plasma levels, along with insulin-stimulated glucose disposal (as measured by the euglycemic-hyperinsulinemic glucose clamp) and oxidative and nonoxidative glucose metabolism (as measured by indirect calorimetry during the last 60 min of the insulin clamp), were measured in 11 anorectic patients and 26 normal-weight healthy female controls. Leptin levels were significantly lower in AN patients, according to the reduced body mass index and their respective fat mass. On the contrary, adiponectin plasma levels were significantly higher in AN patients than in control women. Likewise, insulin-stimulated glucose disposal and nonoxidative glucose metabolism were significantly lower in AN patients. In conclusion, our study shows that young women affected by AN have higher adiponectin plasma levels than healthy female controls of similar age, despite the presence of an impairment of insulin-stimulated glucose disposal, with a prevalent failure of nonoxidative glucose metabolism. Taken together, these data suggest that the reduction of fat mass may play the major role in the control of adiponectin release, with respect to changes in insulin sensitivity.

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“…The peripheral effects of insulin have been reported in¬ creased in anorectic patients (Mecklenburg et al 1974) and the present investigation may be in ac¬ cord with this report. Insulin sensitivity and in¬ sulin clearance in patients with anorexia nervosa have been imported to be both normal (Castillo et al 1985) and increased (Zuniga-Guajardo et al 1986). This discrepancy, as yet unclarified, is prob¬ ably due to differences of examination time and caloric intake.…”

Section: Discussionmentioning

confidence: 99%

Impaired glucagon secretion to insulin-induced hypoglycemia in anorexia nervosa

Fujii

Tamai²,

Kumai³

et al. 1989

Acta Endocrinologica

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In order to clarify the role played by pancreatic \g=a\-celldysfunction in the impaired glucose recovery from hypoglycemia in patients with anorexia nervosa, the response of pancreatic \g=a\-cells to insulin-induced hypoglycemia was investigated in 16 patients with anorexia nervosa before and after treatment. The results were compared with those obtained after loading with arginine. Before treatment, despite comparable falls in plasma glucose levels, glucagon secretion was significantly reduced in the anorectic patients compared with control subjects. In addition, glucose recovery from hypoglycemia in the patients was attenuated. However, after treatment, both glucagon secretory activity and plasma glucose recovery following insulin-induced hypoglycemia were restored to normal. Plasma glucagon responses to arginine infusion were not significantly different in the untreated anorectic patients and control subjects. However, the plasma insulin response in the patients was significantly lower than in the control group. These results suggest that the impaired recovery of plasma glucose levels from insulin-induced hypoglycemia in patients with anorexia nervosa is primarily attributable to impaired pancreatic \g=a\-secretorycapability. In addition, this abnormality in pancreatic \g=a\-cellfunction is reversible with treatment leading to improved nutrition and weight gain.

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Insulin-Stimulated Glucose Disposal Is not Increased in Anorexia Nervosa*

Cited by 49 publications

References 14 publications

Increased lipid and lipoprotein concentrations in anorexia nervosa: A systematic review and meta‐analysis

Increased lipid and lipoprotein concentrations in anorexia nervosa: A systematic review and meta‐analysis

Anorexia Nervosa Is Characterized by Increased Adiponectin Plasma Levels and Reduced Nonoxidative Glucose Metabolism

Impaired glucagon secretion to insulin-induced hypoglycemia in anorexia nervosa

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