Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro

Santos, Lívia; Gonçalves, Luciano; Bagheri-Hanei, Shirin; Möller, Gabriella Berwig; Sale, Craig; James, Ruth; Artioli, Guilherme Giannini

doi:10.1007/s00726-021-03090-9

Cited by 3 publications

(1 citation statement)

References 19 publications

(23 reference statements)

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“…The degree of their involvement in the cellular transportation of amino acids and peptides into the myocardium is unknown. β-alanine and taurine regulate the expression of the transporter TauT within skeletal muscle and decreased β-alanine uptake was shown in an immortalized mouse skeletal muscle cell line (C2C12) exposed to hypotaurine (a TauT inhibitor), suggesting that TauT may be the primary transporter of β-alanine in skeletal muscle ( 44 ). Due to the abundance of taurine in myocardial tissue ( 45 ), it can be postulated that β-alanine would also enter myocardial tissue via this transporter.…”

Section: Myocardial Carnosine Metabolismmentioning

confidence: 99%

Physiological Roles of Carnosine in Myocardial Function and Health

Creighton

Gonçalves

Artioli

et al. 2022

Advances in Nutrition

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Carnosine is a pleiotropic histidine-containing dipeptide synthesized from β-alanine and l-histidine, with the intact dipeptide and constituent amino acids being available from the diet. The therapeutic application of carnosine in myocardial tissue is promising, with carnosine playing a potentially beneficial role in both healthy and diseased myocardial models. This narrative review discusses the role of carnosine in myocardial function and health, including an overview of the metabolic pathway of carnosine in the myocardial tissue, the roles carnosine may play in the myocardium, and a critical analysis of the literature, focusing on the effect of exogenous carnosine and its precursors on myocardial function. By so doing, we aim to identify current gaps in the literature, thereby identifying considerations for future research.

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Section: Myocardial Carnosine Metabolismmentioning

confidence: 99%

Physiological Roles of Carnosine in Myocardial Function and Health

Creighton

Gonçalves

Artioli

et al. 2022

Advances in Nutrition

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β-alanine scavenging of free radicals protects mitochondrial function and enhances both insulin secretion and glucose uptake in cells under metabolic stress

Billacura¹,

Lavilla²,

Cripps³

et al. 2022

Advances in Redox Research

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Essential oil supplementation improves insulin sensitivity and modulates the plasma metabolome of hyperinsulinemic horses

Loos,

Zhao,

et al. 2024

Front. Vet. Sci.

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The objective of this study was to investigate the effect of essential oil (EO) supplementation on insulin sensitivity (IS) and the plasma metabolome in insulin dysregulated (ID) horses. Horses were blocked by degree of IS and assigned randomly to treatment: oral daily bolus (50 mL) of either a plant derived EO supplement or carrier (CON). Mares were housed in dry lots with ad libitum access to grass hay and supplemented individually twice daily with a concentrate to meet nutrient requirements for mature horses. Before and after 6 wks of treatment, mares underwent a combined glucose-insulin tolerance test (CGIT) and an oral sugar test (OST) on separate days. Global metabolome analysis was conducted on plasma samples before and after treatment. Although treatment did not affect (p > 0.4) AUC or glucose clearance during CGIT, there was a treatment*covariate interaction (p ≤ 0.08) for insulin concentrations at 75 min (INS75) and positive phase time (PT) with EO decreasing both INS75 (p ≤ 0.002) and PT (p = 0.05) in horses with more severe initial degree of ID. Similarly, EO treatment reduced (p ≤ 0.006) insulinemic response to the OST in horses exhibiting higher pre-treatment responses (treatment*covariate, p = 0.004). There were 702 metabolites identified that were uniquely changed with EO treatment. Pathway analysis and biomarkers showed EO-mediated changes in amino acid, linoleic acid, mesaconic acid, TCA-cyle intermediates and bile acid metabolism. The directional changes in these pathways or biomarkers are consistent with changes in inulin sensitivity in other models. These data show that EO shifted the plasma metabolome and improved insulin sensitivity in horses.

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Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro

Cited by 3 publications

References 19 publications

Physiological Roles of Carnosine in Myocardial Function and Health

Physiological Roles of Carnosine in Myocardial Function and Health

β-alanine scavenging of free radicals protects mitochondrial function and enhances both insulin secretion and glucose uptake in cells under metabolic stress

Essential oil supplementation improves insulin sensitivity and modulates the plasma metabolome of hyperinsulinemic horses

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