Insulin: The Banting Memorial Lecture 1952

Best, C. H.

doi:10.2337/diab.1.4.257

Cited by 17 publications

(2 citation statements)

References 7 publications

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“…Due to its osmolality, urea contributed, along with glycosuria, to the dramatic water loss of ketoacidosis [5]. The amount of urinary nitrogen excretion could be correlated with glycosuria [6,7], suggesting a common pathogenic factor for these two alterations. In contrast, glycoproteins, as well as some acute phase proteins, were found to be increased [8].…”

Section: Early Studies On Human Amino Acid Metabolismmentioning

confidence: 99%

Stepwise Discovery of Insulin Effects on Amino Acid and Protein Metabolism

Tessari

2023

Nutrients

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A clear effect of insulin deficiency and replacement on body/muscle mass was a landmark observation at the start of the insulin age. Since then, an enormous body of investigations has been produced on the pathophysiology of diabetes mellitus from a hormonal/metabolic point of view. Among them, the study of the effects of insulin on body growth and protein accretion occupies a central place and shows a stepwise, continuous, logical, and creative development. Using a metaphor, insulin may be viewed as a director orchestrating the music (i.e., the metabolic effects) played by the amino acids and proteins. As a hormone, insulin obviously does not provide either energy or substrates by itself. Rather, it tells cells how to produce and utilize them. Although the amino acids can be released and taken up by cells independently of insulin, the latter can powerfully modulate these movements. Insulin regulates (inhibits) protein degradation and, in some instances, stimulates protein synthesis. This review aims to provide a synthetic and historical view of the key steps taken from the discovery of insulin as an “anabolic hormone”, to the in-depth analysis of its effects on amino acid metabolism and protein accretions, as well as of its interaction with nutrients.

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Section: Early Studies On Human Amino Acid Metabolismmentioning

confidence: 99%

Stepwise Discovery of Insulin Effects on Amino Acid and Protein Metabolism

Tessari

2023

Nutrients

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“…Testosterone has a relationship to insulin which is somewhat similar to that of pituitary growth hormone. Experimental evidence has already indicated that the protein anabolic action of testosterone is dependent on insulin (12,13). Not only the pituitary growth hormone, but also testosterone, has been shown to have a diabetogenic effect in experimental animals (14).…”

Section: Insulinmentioning

confidence: 99%

Overeating and Vascular Degeneration: Excesses Causing Insufficiencies

Solez

1958

J American Geriatrics Society

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Effects of insulin on whole‐body and regional amino acid metabolism

Tessari

1994

Diabetes Metab. Rev.

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~ Effect Tissue References Protein degradation J Ribosome degradation Macromolecule degradation (lysosomal) t Protein synthesis T mRNA transcription T mRNA translation t mRNA stability t Ternary complex formation J AA oxidation and deamination t AA transport Skeletal muscle Fibroblasts Cardiac muscle Liver 1 5 2 7 Skeletal muscle Liver 16,24,33,34, 37,38,40,42,43 Skeletal muscle in fed animals 52 Hepatocytes 56,57,6042, Fibroblasts Skeletal muscle 145,146 AA = Amino acid. in vivo. A m f Physiol 262: E92SE935, 1992. Tessari P, Nissen SL, Miles JM, and Haymond MW: Inverse relationship of leucine flux and oxidation to free-fatty acid availability in vivo. J Clin Invest 77: 575-581, 1986. Beaufrere 8, Chassard D, Broussolle C, Riou JP, and Beylot M: Effect of D-P-hydroxybutyrate and long-and medium-chain triglycerides on leucine metabolism in humans. A m Physiol 262: E26bE274, 1992. Nair KS, Welle SL, Halliday D, and Campbell RG: Effect of P-hydroxybutyrate on wholebody leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans. J Clin Invest 92: 198-205, 1988. Miles JM, Nissen SL, Rizza RA, Gerich JE, and Haymond MW: Failure of infused betahydroxybutyrate to decrease proteolysis in man.

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Insulin: The Banting Memorial Lecture 1952

Cited by 17 publications

References 7 publications

Stepwise Discovery of Insulin Effects on Amino Acid and Protein Metabolism

Stepwise Discovery of Insulin Effects on Amino Acid and Protein Metabolism

Overeating and Vascular Degeneration: Excesses Causing Insufficiencies

Effects of insulin on whole‐body and regional amino acid metabolism

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