Insulin Treatment of Postoperative (Nondiabetic) Acidosis

Thalhimer, William

doi:10.1001/jama.1923.02650050037013

Cited by 35 publications

(5 citation statements)

References 1 publication

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“…In 1923, William Thalhimer was the first to describe the insulin activity in postoperative acidosis [ 44 ]. In parallel, Foster showed improvement in postoperative recovery among 20 diabetic patients receiving between 30 and 75 of insulin units intravenously.…”

Section: Effect Of Insulin In Wound Healingmentioning

confidence: 99%

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Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

et al. 2021

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Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers.

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Section: Effect Of Insulin In Wound Healingmentioning

confidence: 99%

“…In 1923, William Thalhimer was the first to describe the insulin activity in postoperative acidosis [44]. In parallel, Foster showed improvement in postoperative recovery Increased capillary permeability induced by burns leads to leakage of small protein molecules and edema [38].…”

Section: Diabetic Woundsmentioning

confidence: 99%

Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

et al. 2021

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“…ther complications arose Thalhofer the irst to report insulin use as a means to treat postoperative (non-diabetic) acidosis [10], had been monitoring three patients who had undergone surgery and were suffering from severe vomiting and post-operative metabolic imbalance. This work showed that there was strong evidence linking acidosis with the development of severe infection and death.…”

Section: /6mentioning

confidence: 99%

The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications

DH¹

2016

JAPLR

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“…Thalhofer, the first to report insulin use as a means to treat postoperative (non-diabetic) acidosis [10], had been monitoring three patients who had undergone surgery and were suffering from severe vomiting and post-operative metabolic imbalance. This work showed that there was strong evidence linking acidosis with the development of severe infection and death.…”

Section: /6mentioning

confidence: 99%

The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications

DH¹

2016

JAPLR

View full text Add to dashboard Cite

Insulin Treatment of Postoperative (Nondiabetic) Acidosis

Cited by 35 publications

References 1 publication

Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications

The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications

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