Insulinogenic index at 15min as a marker of stable eating behavior in bulimia nervosa

Yasuhara, Daisuke; Tatebe, Yoshiki; Nakayama, Takashi; Muranaga, Tetsuro; Nozoe, Shigeo; Naruo, Tetsuro

doi:10.1016/j.clnu.2003.12.001

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…On the other hand, some investigators have described an exaggerated insulin response to a glucose challenge in purging BN individuals 191,193 similar to that seen in alcoholics. 194 If increased insulin results in diminished DA activity, this supports the ''reward deficiency'' hypothesis whereby reward-seeking behaviors (ie, binge eating) compensate for low DA.…”

Section: Peripheral Hormonesmentioning

confidence: 87%

From Disordered Eating to Addiction

Umberg¹,

Shader²,

Hsu³

et al. 2012

Journal of Clinical Psychopharmacology

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The high prevalence of substance abuse in individuals with bulimia nervosa (BN) and the pervasive symptom substitution in many types of drug addiction suggest that a number of substances--including food--can impair an individual's self-control, even in the presence of negative consequences. Nonetheless, the neurobiological similarities between BN and drug addiction are not clearly established. This review explores how the specific eating patterns seen in BN (binge eating and purging, with intermittent dietary restriction) are particularly addictive and differentiate BN from other eating disorders and obesity. A number of peripheral and central biological aberrations seen in BN may result in altered reward sensitivity in these individuals, particularly through effects on the dopaminergic system. Neurobiological findings support the notion that BN is an addictive disorder, which has treatment implications for therapy and pharmacological manipulations.

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Section: Peripheral Hormonesmentioning

confidence: 87%

From Disordered Eating to Addiction

Umberg¹,

Shader²,

Hsu³

et al. 2012

Journal of Clinical Psychopharmacology

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“…Seven studies of patients with BN were included in the systematic review with a total of 301 participants (145 BN cases and 156 controls), all of whom were female (Table 1) (Bello et al, 2010, Dynesen et al, 2008, Karountzos et al, 2016, Kojima et al, 2005, Pijl et al, 1995, Tagami et al, 2004, Yasuhara et al, 2004. Five studies were observational and used a case-control design, and two were randomised controlled trials in BN.…”

Section: Bulimia Nervosa and Binge-eating Disordermentioning

confidence: 99%

“…For the primary meta-analysis, three studies have appropriate data for BN (n=120) (Pijl et al, 1995, Tagami et al, 2004, Yasuhara et al, 2004 and two for BED (n=3,241) (Abraham et al, 2014, Succurro et al, 2015.. Given the small number of studies available for BN and BED, we therefore conducted a combined meta-analysis of exploratory nature.…”

Section: Bulimia Nervosa and Binge-eating Disordermentioning

confidence: 99%

“…Mean BMI and age of participants were reported in all studies except one study of AN (Dolezalova et al, 2007). All case-control studies reported matching for controls on age, except for two studies of AN (Broglio et al, 2004, Nogueira et al, 2013 and two studies of BN (Pijl et al, 1995, Yasuhara et al, 2004. However, other important confounding factors such as BMI and waist circumference were…”

Section: Risk Of Bias and Strength Of Evidencementioning

confidence: 99%

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The metabolic underpinning of eating disorders: A systematic review and meta-analysis of insulin sensitivity

Ilyas

Hübel

Ståhl

et al. 2019

Molecular and Cellular Endocrinology

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“…Subsequent clinical investigations of total serum amylase suggest that it is elevated in persons with BN who experience vomiting [6, 12, 13] or dental enamel erosion suggestive of self-induced vomiting [10], although this has not been observed in all studies [14]. Other investigations have found that serum amylase correlates with frequency of binge eating episodes [5, 12], although this may not hold true for individuals with the non-purging subtype of the disorder [15].…”

Section: Introductionmentioning

confidence: 99%

Serum amylase in bulimia nervosa and purging disorder: Differentiating the association with binge eating versus purging behavior

Wolfe

Jimerson

Smith

et al. 2011

Physiology & Behavior

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Objective Elevated serum amylase levels in bulimia nervosa (BN), associated with increased salivary gland size and self-induced vomiting in some patients, provide a possible marker of symptom severity. The goal of this study was to assess whether serum hyperamylasemia in BN is more closely associated with binge eating episodes involving consumption of large amounts of food or with purging behavior. Method Participants included women with BN (n=26); women with “purging disorder” (PD), a subtype of EDNOS characterized by recurrent purging in the absence of objectively large binge eating episodes (n=14); and healthy non-eating disorder female controls (n=32). There were no significant differences in age or body mass index (BMI) across groups. The clinical groups reported similar frequency of self-induced vomiting behavior and were free of psychotropic medications. Serum samples were obtained after overnight fast and were assayed for alpha-amylase by enzymatic method. Results Serum amylase levels were significantly elevated in BN (60.7 ± 25.4 international units [IU]/liter, mean ± sd) in comparison to PD (44.7 ± 17.1 IU/L, p < 02) and to Controls (49.3 ± 15.8, p < .05). Conclusion These findings provide evidence to suggest that it is recurrent binge eating involving large amounts of food, rather than self-induced vomiting, which contributes to elevated serum amylase values in BN.

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Insulinogenic index at 15min as a marker of stable eating behavior in bulimia nervosa

Cited by 8 publications

References 34 publications

From Disordered Eating to Addiction

From Disordered Eating to Addiction

The metabolic underpinning of eating disorders: A systematic review and meta-analysis of insulin sensitivity

Serum amylase in bulimia nervosa and purging disorder: Differentiating the association with binge eating versus purging behavior

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