Insulinogenic sucrose + amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose + amino acid mixture in growing rats

Notomi, Takuya; Karasaki, Ikuaki; Okazaki, Yukio; Okimoto, Nobukazu; Kato, Yushi; Ohura, Kiyoshi; Noda, Masaki; Nakamura, Toshio; Suzuki, Masashige

doi:10.1016/j.bone.2014.05.002

Cited by 17 publications

(12 citation statements)

References 27 publications

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“…Decreased RANKL levels and increased OPG levels have been observed in an experiment using acute training murine MC3T3-E1 osteoblasts [108]. In a chronic exercise study which was conducted in rats, an enhancement in the OPG/RANKL ratio was shown because of a decrease in RANKL expression [104]. On the other hand, an in vitro study has illustrated that mechanical strain could lead to abundance in OPG levels and decreases in M-CSF levels without alterations in RANKL levels in human osteoblasts [109].…”

Section: Favorable Effects Of Exercise On Bone Health By Rankl/ Rank/mentioning

confidence: 93%

“…ere is some strong evidence that demonstrated exercise decline mRNA levels of markers from bone resorption like TRAP, cathepsin-K, and calcitonin receptors [102]. Moreover, participating in exercise could increase some osteogenic markers like OCL, Runx2, Osx, BAP, BMP2, and collagen type 1 in osteoblasts [15,[103][104][105]. It has been demonstrated that BAP and OCL, which are bone formation markers, are upregulated and TRAP (tartrateresistant acid phosphatase), which is a bone resorption marker, is downregulated within an 8-week exercise plan in women [65,103].…”

Section: Exercise and Bonementioning

confidence: 99%

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RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Tobeiha

Moghadasian

Amin

et al. 2020

BioMed Research International

186

114

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Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG pathway.

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Section: Favorable Effects Of Exercise On Bone Health By Rankl/ Rank/mentioning

confidence: 93%

Section: Exercise and Bonementioning

confidence: 99%

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Tobeiha

Moghadasian

Amin

et al. 2020

BioMed Research International

186

114

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“…There are several possible reasons for these findings. First, amino acid ingestion has been reported to modestly increase insulin levels [35–37] and co-ingestion of protein or amino acids with carbohydrate has been reported to promote a greater effect on insulin [35, 36, 38–42]. The FB studied contained 25 g of IMO with 20 g of whey protein.…”

Section: Discussionmentioning

confidence: 99%

Comparison of ingesting a food bar containing whey protein and isomalto-oligosaccharides to carbohydrate on performance and recovery from an acute bout of resistance-exercise and sprint conditioning: an open label, randomized, counterbalanced, crossover pilot study

Grubic

Sowinski

Nevares

et al. 2019

Journal of the International Society of Sports Nutrition

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We previously reported that consuming a food bar (FB)containing whey protein and the plant fiber isomalto‐oligosaccharides [IMO] hada lower glycemic but similar insulinemic response as a high glycemic indexcarbohydrate. Therefore, we hypothesized that ingestion of this FB prior to, during, and following intense exercise would better maintain glucosehomeostasis and exercise capacity during exercise as well as hasten recovery incomparison to a carbohydrate matched placebo (PLA). Twelve resistance‐trainedmales participated in an open label, randomized, counterbalanced, cross‐overtrial with a 7‐d washout period. Participants consumed a carbohydrate matcheddextrose PLA or a FB containing 20 g of whey, 25 g of IMO, and 7 g of fat 30‐min prior to, mid‐way, and following intense exercise. Participantsperformed 11 resistance‐exercises (3 sets of 10 repetitions at 70% of onerepetition maximum) followed by performing agility and sprint conditioningdrills for time. Participants donated blood samples, performed isokineticstrength tests, and rated perceptions of muscle soreness and hypoglycemia priorto and following exercise and after 48 hours of recovery. Data were analyzed bygeneral linear model repeated measures and are reported as mean change frombaseline with 95% confidence intervals. Results revealed that blood glucose wassignificantly higher 30‐min post‐ingestion with PLA (PLA 3.1 [2.0, 4.3], FB 0.8[0.2, 1.5] mmol/L, p=0.001) while post‐exercise ratio of insulin to glucose wasgreater with FB (PLA 0.04 [0.00, 0.08], FB 0.11 [0.07, 0.15], p=0.013, η2=0.25). Total lifting volume was maintained toa greater degree from Set 1 to Set 3 with FB than PLA (PLA −198.26 [−320.1, −76.4], FB −81.7 [−203.6, 40.1] kg, p=0.175, η2=0.08). Ratings of muscle soreness of thedistal vastus medialis to a standard amount of pressure were lower with FB (PLA1.88 [0.60, 3.17]; FB 0.29 [−0.99, 1.57] cm, p=0.083, η2=0.13). However, no significant differences were observed between treatments in sprintperformance, isokinetic strength, markers of catabolism, stress and sexhormones, or inflammatory markers. Results indicate that ingestion ofthis FB can positively affect glucose homeostasis, sustain exerciseperformance, and lessen perceptions of muscle soreness after intense training. Support or Funding Information This study was supported internally by Dr. Richard B. Kreider and the Exercise and Sport Nutrition Laboratory at Texas A&M University as part of a student dissertation. Dr. Conrad Earnest served as a Director of Clinical Sciences for Nutrabolt. Dr. Kreider served as a university approved scientific advisor for Nutrabolt. Dr. Peter Murano serves as Texas A&M University approved quality assurance supervisor. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

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“…Moderate exercise contributes to increasing the expression of OPG and decreasing the expression of RANKL and, as a consequence, to inhibit osteoclast differentiation and activity. Notomi et al have previously demonstrated that resistance training increased the OPG expression in rats [ 69 ]. Treadmill and vibration stimulation training downregulated RANKL expression and upregulated OPG expression in bone cells in a rat model with glucocorticoid-induced osteoporosis [ 56 ].…”

Section: Bone Parameters Studiedmentioning

confidence: 99%

Does Physical Exercise Always Improve Bone Quality in Rats?

Portier

Benaîtreau

Pallu

2020

Life

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For decades, the osteogenic effect from different physical activities on bone in rodents remained uncertain. This literature review presents for the first time the effects on five exercise models (treadmill running, wheel running, swimming, resistance training and vibration modes) in three different experimental rat groups (males, females, osteopenic) on bone quality. The bone parameters presented are bone mineral density, micro-architectural and mechanical properties, and osteoblast/osteocyte and osteoclast parameters. This review shows that physical activities have a positive effect (65% of the results) on bone status, but we clearly observed a difference amongst the different protocols. Even if treadmill running is the most used protocol, the resistance training constitutes the first exercise model in term of osteogenic effects (87% of the whole results obtained on this model). The less osteogenic model is the vibration mode procedure (31%). It clearly appears that the gender plays a role on the bone response to swimming and wheel running exercises. Besides, we did not observe negative results in the osteopenic population with impact training, wheel running and vibration activities. Moreover, about osteoblast/osteocyte parameters, we conclude that high impact and resistance exercise (such jumps and tower climbing) seems to increase bone formation more than running or aerobic exercise. Among the different protocols, literature has shown that the treadmill running procedure mainly induces osteogenic effects on the viability of the osteocyte lineage in both males and females or ovariectomized rats; running in voluntary wheels contributes to a negative effect on bone metabolism in older male models; whole-body vertical vibration is not an osteogenic exercise in female and ovariectomized rats; whereas swimming provides controversial results in female models. For osteoclast parameters only, running in a voluntary wheel for old males, the treadmill running program at high intensity in ovariectomized rats, and the swimming program in a specific ovariectomy condition have detrimental consequences.

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Insulinogenic sucrose + amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose + amino acid mixture in growing rats

Cited by 17 publications

References 27 publications

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Comparison of ingesting a food bar containing whey protein and isomalto-oligosaccharides to carbohydrate on performance and recovery from an acute bout of resistance-exercise and sprint conditioning: an open label, randomized, counterbalanced, crossover pilot study

Does Physical Exercise Always Improve Bone Quality in Rats?

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