Insulinoma pancreático: casuística de um hospital central e revisão da literatura

Caldas, Ana Rita; Teixeira, Sofía; Giestas, A.; Amaral, Claudia; Cardoso, Maria Helena

doi:10.1016/j.rpedm.2015.06.002

Cited by 6 publications

(16 citation statements)

References 66 publications

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“…Positron Emission Computed Tomography (PET-CT) shows promising results. PET-CT with Gallium-radiolabeled peptides has presented better results than somatostatin receptor scintigraphy in some recent studies [ 5 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Intraoperative USG can be used to increase surgical accuracy in lesions which have not been previously found or to confirm tumor location in case of doubt. In addition, it assists in choosing the best surgical technique, reducing the number of iatrogenic lesions [ 5 , 17 ]. This type of ultrasonography study has approximately 85% sensitivity and can also perform intraoperative staging [ 10 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…This type of neuroendocrine tumor represents an unusual but usually curable cause of hypoglycemia and accounts for 2% of all gastrointestinal tract neoplasms, with an annual incidence of 1–2 per 100,000 inhabitants [ 2 , 3 ]. It is more commonly found in females (60% of cases), between the fourth and sixth decades of life, and with a mean age at diagnosis of 45 years [ [4] , [5] , [6] , [7] ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical resection of pancreatic insulinoma during pregnancy: Case report and literature review

Neto

Lira

Albuquerque

et al. 2019

International Journal of Surgery Case Reports

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Highlights Insulinomas represent an unusual but usually curable cause of hypoglycemia. Surgery is still the only possibly curative treatment for pancreatic neuroendocrine tumors. There are a limited number of cases of insulinoma treated during pregnancy. In all reported cases, both the woman and the child experienced good results.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surgical resection of pancreatic insulinoma during pregnancy: Case report and literature review

Neto

Lira

Albuquerque

et al. 2019

International Journal of Surgery Case Reports

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“…Tal como descrito na literatura, pode haver um atraso significativo no diagnóstico de insulinoma, visto que as manifestações clínicas são inespecíficas e comuns a outras patologias neurológicas/psiquiátricas. 7 Salientamos a clínica apresentada e o facto da doente referir que conseguiu durante muito tempo evitar a sintomatologia com a ingestão de várias refeições diárias. Neste caso foi possível a avaliação simultânea de glicemia plasmática, insulina e peptídeo-C num episódio de hipoglicemia espontânea, não sendo necessário realizar a prova de jejum prolongado, considerado o "gold standard" no diagnóstico de hipoglicemia.…”

Section: Discussionunclassified

Insulinoma: Uma Causa Rara de Hipoglicemia

Matta-Coelho

Monteiro

Marques

2018

Gaz Med

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O insulinoma é o tumor neuroendócrino pancreático funcionante mais frequente. A apresentação clínica variável pode mimetizar outras patologias. Doente do sexo feminino, 61 anos, com vários episódios de alteração do comportamento. Num desses episódios verificou-se hipoglicemia. O estudo etiológico revelou valores inapropriadamente elevados de insulina e peptídeo-C, compatíveis com hiperinsulinismo endógeno. Apesar da tomografia computadorizada, ressonância magnética e cintigrafia dos recetores de somatostatina não revelarem nenhuma lesão, a ecoendoscopia demonstrou uma formação nodular infracentrimétrica pancreática cujo diagnóstico citológico foi concordante com insulinoma. A doente foi submetida a excisão da lesão e mantém-se sem queixas. Salientamos a apresentação clínica inespecífica e a pequena dimensão da lesão, o que pode levar a um hiato temporal significativo entre o início da sintomatologia e o tratamento. Recebido: 02/06/2017 - Aceite: 27/10/2017

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“…They considered variables such as age, sex, classification of tumors as sporadic or familial, functioning or non-functioning tumor, type of tumor, location, surgical technique, tumor size, multifocal tumors, and recurrence rate [4]. Concerning the diagnosis of PNETs, positronemitting tomography integrated with computed tomography (PET/CT) associated with radiopharmaceuticals is a promising technique in recent years [9].…”

Section: Pancreatic Neuroendocrine Tumors (F-pnets)mentioning

confidence: 99%

Pancreatic Neuroendocrine Tumors: A Literature Review

Gomes¹,

Laiso²,

Knop³

et al. 2020

JBTH

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Pancreatic neuroendocrine tumors (PNETs) affect 1%-3% of patients with pancreatic cancer. This tumor is rare, difficult to diagnose, and clinically laborious. They have an estimated incidence of up to 1 case per 100,000 inhabitants every year. Up on diagnosis, most PNETs are considered malignant, with low healing potential, lesions that are generally unresectable, and a metastasis rate of aproximately 50%. PNETs are classified as functional and non-functional. The tumor functional produces hormones such as gastrin, insulin, somatostatin, glucagon, among others. They are symptomatic due to hormonal hypersecretion and occur in 30% of cases. The other 70% are non-functioning, and despite producing a series of substances and some hormones such as beta HCG and alpha HCG, they are silent tumors, with no significant clinical syndrome. The present study presented scientific evidence about PNETs, the types of pancreas endocrine-tissue tumors, the rate of survival, diagnosis, treatments, and prognosis, to provide solid support to professionals, and contribute to effective decision-making in search of the best clinical outcome.

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Insulinoma pancreático: casuística de um hospital central e revisão da literatura

Cited by 6 publications

References 66 publications

Surgical resection of pancreatic insulinoma during pregnancy: Case report and literature review

Surgical resection of pancreatic insulinoma during pregnancy: Case report and literature review

Insulinoma: Uma Causa Rara de Hipoglicemia

Pancreatic Neuroendocrine Tumors: A Literature Review

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