This essay discusses settler-colonialism in Palestine and the world system during late neocolonialism. It offers a materialist methodology for interpreting settler-colonial social formations, showing the linkage between settler-colonialism, class, imperialism, and world accumulation. It then considers how race continues to structure local reactions and condition local and international attempts at transformation. It concludes with some reflections on contemporary orientations to Palestine in the periphery, especially within racialized social formations.