2024
DOI: 10.1101/2024.04.08.588579
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Intact and Degenerate Diguanylate Cyclases regulateShigellaCyclic di-GMP

Ruchi Ojha,
Stefanie Krug,
Prentiss Jones
et al.

Abstract: The intracellular human pathogenShigellainvades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine. To adapt to changing environments,Shigellauses the bacterial second messenger c-di-GMP signaling system, synthesized by diguanylate cyclases (DGCs) encoding GGDEF domains.Shigella flexneriencodes a total of 9 GGDEF or GGDEF-EAL domain enzymes in its genome, but 5 of these genes ha… Show more

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