Intact autocrine activation and cytokine production by PMNs from injured adults with elevated Candida antigen titres

Sweeney, John F.; Rosemurgy, Alexander S.; Wei, Sheng; Djeu, Julie Y.

doi:10.1016/s0020-1383(97)00123-x

Cited by 2 publications

(1 citation statement)

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“…PMNs release a number of cytokines, chemokines, alarmins, proteases, growth factors, and IFNs into the inflammatory milieu, thus playing important roles in eliciting and sustaining inflammation, as well as contributing significantly to the regulation of key immune responses during infection . The continuous migration of large numbers of cytokine‐producing PMNs across the mucosal epithelia can lead to locally high concentrations of cytokines, including (but not limited to) IL‐1α, IL‐1β, and TNF‐α , as well as other inflammatory mediators in close proximity to the mucosal epithelium.…”

Section: Function Of Neutrophils During Homeostasis and Infection/infmentioning

confidence: 99%

Pathobiology of neutrophil–epithelial interactions

Brazil

Parkos

2016

Immunological Reviews

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Summary Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to sites of infection/inflammation requires exiting the microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the lungs and intestines. Although these processes usually occur without significant damage to surrounding host tissues, dysregulated/excessive PMN transmigration and resultant bystander-tissue damage are characteristic of numerous mucosal inflammatory disorders. Mechanisms controlling PMN extravasation have been well characterized, but the molecular details regarding regulation of PMN migration across mucosal epithelia are poorly understood. Given that PMN migration across mucosal epithelia is strongly correlated with disease symptoms in many inflammatory mucosal disorders, enhanced understanding of the mechanisms regulating PMN transepithelial migration should provide insights into clinically relevant tissue-targeted therapies aimed at ameliorating PMN-mediated bystander-tissue damage. This review will highlight current understanding of the molecular interactions between PMNs and mucosal epithelia and the associated functional consequences.

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Section: Function Of Neutrophils During Homeostasis and Infection/infmentioning

confidence: 99%