Intact circadian rhythm despite cortisol hypersecretion in Alzheimer’s disease: A meta-analysis

Saelzler, Ursula G.; Verhaeghen, Paul; Panizzon, Matthew S.; Moffat, Scott D.

doi:10.1016/j.psyneuen.2021.105367

Cited by 14 publications

(13 citation statements)

References 151 publications

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“…HPA axis dysregulation and elevated basal cortisol levels, which occur in patients with AD, contrib ute significantly to the pathogenesis of the disease. [49,50]. The observed GC hypersecretion is mechanistically consistent with a theoretically predicted deterioration of the hippocampal state in AD followed by a decline in the ability of GCs to inhibit the HPA axis.…”

Section: Hyperglutamatergic Conditions In Brain Pathologies and Gluco...supporting

confidence: 76%

Neuroendocrine Control of Hyperglutamatergic States in Brain Pathologies: the Effects of Glucocorticoids

Gulyaeva

2022

J Evol Biochem Phys

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Neuroendocrine control mediated by glucocorticoids is important for maintaining the normal functioning of the brain and the balance between the excitation and inhibition systems. Glucocorticoids regulate the state of the brain glutamatergic system both directly, through receptors on glutamatergic synapses, and indirectly. The dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis and its inability to optimally regulate glutamatergic synaptic plasticity leads to the development of neuropsychiatric diseases, while hyperglutamatergic conditions can play a key role in their pathogenesis. Impaired glucocorticoid control of glutamatergic processes underlies cognitive and emotional disorders, epilepsy and a number of other cerebral pathologies, being a common mechanism for the development of many brain diseases and their comorbidities. In this regard, the study of the mechanisms of interaction between the HPA axis and brain glutamatergic system is of priority translational significance.

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Section: Hyperglutamatergic Conditions In Brain Pathologies and Gluco...supporting

confidence: 76%

Neuroendocrine Control of Hyperglutamatergic States in Brain Pathologies: the Effects of Glucocorticoids

Gulyaeva

2022

J Evol Biochem Phys

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“…A growing body of evidence suggests that abnormal level of the glucocorticoid hormone is linked with key hallmarks of AD pathogenesis. [5][6][7] Such observations lend credence to the "glucocorticoid-cascade" hypothesis which suggests that chronic glucocorticoid secretion, as seen after prolonged stress exposure, may contribute to the etiopathogenic pathway leading to cognitive decline and AD in the elderly. [8] Activation of the hypothalamic-pituitary-adrenal (HPA) axis results in the production of glucocorticoids, secreted in the form of cortisol in humans, as a response to stress and for maintaining homeostasis.…”

Section: Introductionmentioning

confidence: 63%

“…A growing body of evidence suggests that abnormal level of the glucocorticoid hormone is linked with key hallmarks of AD pathogenesis [5–7] . Such observations lend credence to the “glucocorticoid-cascade” hypothesis which suggests that chronic glucocorticoid secretion, as seen after prolonged stress exposure, may contribute to the etiopathogenic pathway leading to cognitive decline and AD in the elderly [8] .…”

Section: Introductionmentioning

confidence: 92%

High cortisol and the risk of Alzheimer disease

et al. 2021

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Background: Morning cortisol levels have been reported to be elevated among patients with Alzheimer disease (AD). We perform a protocol for systematic review and meta-analysis to assess morning central or peripheral cortisol levels in AD patients as compared with cognitively normal individuals. Methods: Studies were identified through systematic searches in August 2021 with no restrictions on date and time, language, and publication status using the following bibliographic databases: Embase, Medline, PubMed, Web of Science, Science Direct, and the Cochrane Library. Studies were identified using search terms related to cortisol, Alzheimer disease, and cognitive impairment. The study quality of included papers was evaluated using the “National Institutes of Health (NIH) quality assessment tool for observational cohort and cross-sectional studies.” Statistical analyses were performed using Stata (version 14, StataCorp, College Station, TX). Results: The findings of this study will be submitted to peer-reviewed journals for publication. Conclusion: Morning cortisol was elevated in AD patients and may have diagnostic and prognostic values for AD.

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“…[ 97–99 ] Cortisol rhythm disruptions in older individuals may reflect the progression of neurodegeneration; although, not all studies support this assumption. [ 100–103 ] An association between MCI and cortisol rhythm changes has been reported by several studies, [ 15,21,102–125 ] some of which compared MCI patients with control groups. [ 114,115,123,124 ] For example, a mild elevation of morning cortisol was observed in cerebrospinal fluids from patients with MCI compared to healthy, age‐matched individuals.…”

Section: Circadian Rhythm Changes In Healthy Aging and MCImentioning

confidence: 99%

Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

2022

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Disruptions in circadian rhythms can occur in healthy aging; however, these changes are more severe and pervasive in individuals with age‐related and neurodegenerative diseases, such as dementia. Circadian rhythm alterations are also present in preclinical stages of dementia, for example, in patients with mild cognitive impairments (MCI); thus, providing a unique window of opportunity for early intervention in neurodegenerative disorders. Nonetheless, there is a lack of studies examining the association between relevant changes in circadian rhythms and their relationship with cognitive dysfunctions in MCI individuals. In this review, circadian system alterations occurring in MCI patients are examined compared to healthy aging individuals while also considering their association with MCI neurocognitive alterations. The main findings are that abnormal circadian changes in rest‐activity, core body temperature, melatonin, and cortisol rhythms appear in the MCI stage and that these circadian rhythm disruptions are associated with some of the neurocognitive deficits observed in MCI patients. In addition, preliminary evidence indicates that interventions aimed at restoring regular circadian rhythms may prevent or halt the progress of neurodegenerative diseases and mitigate their related cognitive impairments. Future longitudinal studies with repeated follow‐up assessments are needed to establish the translational potential of these findings in clinical practice.

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Intact circadian rhythm despite cortisol hypersecretion in Alzheimer’s disease: A meta-analysis

Cited by 14 publications

References 151 publications

Neuroendocrine Control of Hyperglutamatergic States in Brain Pathologies: the Effects of Glucocorticoids

Neuroendocrine Control of Hyperglutamatergic States in Brain Pathologies: the Effects of Glucocorticoids

High cortisol and the risk of Alzheimer disease

Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

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