Intact Cognitive Inhibition in Patients With Fibromyalgia but Evidence of Declined Processing Speed

Veldhuijzen, Dieuwke S.; Sondaal, Stephanie F.V.; Oosterman, Joukje M.

doi:10.1016/j.jpain.2012.02.011

Cited by 78 publications

(77 citation statements)

References 47 publications

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“…In line with studies in the literature, we did not observe deficits in the subcomponents of inhibition or access of EF. Veldhuijzen and colleagues (42), in investigating the ability of FM patients to inhibit preponderant information, evidenced a slower performance than that of the controls but equal accuracy. This finding parallels our results on the N-Back task and may then point to an underlying problem of mental processing speed and/or psychomotor speed (42).…”

Section: Discussionmentioning

confidence: 96%

“…Veldhuijzen and colleagues (42), in investigating the ability of FM patients to inhibit preponderant information, evidenced a slower performance than that of the controls but equal accuracy. This finding parallels our results on the N-Back task and may then point to an underlying problem of mental processing speed and/or psychomotor speed (42). Evidence that FM patients are not impaired in the access domain is accumulating; FM patients did not show impairments in verbal fluency, either phonemic (43) or semantic (40).…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Are Fibromyalgia Patients Cognitively Impaired? Objective and Subjective Neuropsychological Evidence

Tesio

Torta

Colonna

et al. 2014

Arthritis Care & Research

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Are Fibromyalgia Patients Cognitively Impaired? Objective and Subjective Neuropsychological Evidence

Tesio

Torta

Colonna

et al. 2014

Arthritis Care & Research

View full text Add to dashboard Cite

“…Significant decrements in processing speed have been documented in FMS patients using a variety of tests [186,192,202,203], even though normal results have also been obtained with certain tasks [204,205], and occasionally, FMS patients perform even better than controls [202]. However, it is often not possible to clearly distinguish between reduced mental processing speed, decreased psychomotor speed, or a combination of both [206].…”

Section: Cognitive Complaints/fibrofogmentioning

confidence: 99%

“…Depression or depressive symptoms show associations with some of the cognitive dysfunction in FMS, but they fully explain them in only a few studies, partly explain them in others, and do not show any association in the remainder [187,191,192,198,200,206]. These discrepancies may arise because the effects of depressive symptoms appear to be domain-or even task-specific [183,198,209] and because different instruments were used for assessing depressive symptoms.…”

Section: Cognitive Complaints/fibrofogmentioning

confidence: 99%

Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

229

217

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Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise classification. It is often considered as part of the global overview of functional somatic syndromes that are otherwise medically unexplained or part of a somatization disorder. Patients with fibromyalgia share symptoms with other functional somatic problems, including issues of myalgias, arthralgias, fatigue and sleep disturbances. Indeed, there is often diagnostic and classification overlap for the case definitions of a variety of somatization disorders. Fibromyalgia, however, is a critically important syndrome for physicians and scientists to be aware of. Patients should be taken very seriously and provided optimal care. Although inflammatory, infectious, and autoimmune disorders have all been ascribed to be etiological events in the development of fibromyalgia, there is very little data to support such a thesis. Many of these disorders are associated with depression and anxiety and may even be part of what has been sometimes called affected spectrum disorders. There is no evidence that physical trauma, i.e., automobile accidents, is associated with the development or exacerbation of fibromyalgia. Treatment should be placed on education, patient support, physical therapy, nutrition, and exercise, including the use of drugs that are approved for the treatment of fibromyalgia. Treatment should not include opiates and patients should not become poly pharmacies in which the treatment itself can lead to significant morbidities. Patients with fibromyalgia are living and not dying of this disorder and positive outlooks and family support are key elements in the management of patients.

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“…We found that reactive inhibition was faster during and immediately after anodal tDCS relative to sham. attention-deficit hyperactivity disorder (ADHD; Aron and Poldrack 2005;Barkley 1997; Rubia et al 2001), schizophrenia (Enticott et al 2008;Kiehl et al 2000), obsessivecompulsive disorder and trichotillomania (Bohne et al 2008;Menzies et al 2007;Penadés et al 2007), Tourette syndrome (Ziemann et al 1997), chronic pain (Glass et al 2011;Jongsma et al 2011;Veldhuijzen et al 2012) and developmental stuttering (Eggers et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex

2015

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Stopping outright (reactive inhibition) and slowing down (proactive inhibition) are types of response inhibition which have mainly been investigated in the manual effector system. This study compared reactive inhibition across manual and vocal effector systems, examined the effects of excitatory anodal transcranial direct current stimulation (anodal tDCS) over the right prefrontal cortex (right-PFC) and looked at the relationship between reactive and proactive inhibition. We hypothesised (1) that vocal reactive inhibition would be less effective than manual reactive inhibition as evidenced by longer stop signal reaction times; (2) that anodal tDCS would enhance both vocal and manual reactive inhibitions and (3) that proactive and reactive inhibitions would be positively related. We tested 14 participants over two sessions (one session with anodal tDCS and one session with sham stimulation) and applied stimulation protocol in the middle of the session, i.e. only during the second of three phases. We used a stop signal task across two stop conditions: relevant and irrelevant stop conditions in which stopping was required or ignored, respectively. We found that reactive inhibition was faster during and immediately after anodal tDCS relative to sham. We also found that greater level of proactive inhibition enhanced reactive inhibition (indexed by shorter stop signal reaction times). These results support the hypothesis that the right-PFC is part of a core network for reactive inhibition and supports previous contention that proactive inhibition is possibly modulated via preactivating the reactive inhibition network.

show abstract

Intact Cognitive Inhibition in Patients With Fibromyalgia but Evidence of Declined Processing Speed

Cited by 78 publications

References 47 publications

Are Fibromyalgia Patients Cognitively Impaired? Objective and Subjective Neuropsychological Evidence

Are Fibromyalgia Patients Cognitively Impaired? Objective and Subjective Neuropsychological Evidence

Fibromyalgia: A Critical and Comprehensive Review

Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex

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