Intact neurovascular coupling during executive function in migraine without aura: Interictal near-infrared spectroscopy study

Schytz, Henrik Winther; Çiftçi, Koray; Akin, Ata; Ashina, Messoud; Bolay, Hayrünnisa

doi:10.1111/j.1468-2982.2009.01986.x

Cited by 26 publications

(21 citation statements)

References 66 publications

(101 reference statements)

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“…Given that the stop signal reaction time (SSRT) provides an effective means of quantifying the latency of the inhibition mechanism, the slower SSRT implied a decrease or disruption in response inhibition in migraineurs. Such poorer performance during a stop signal task is in line with previous studies reporting that migraineurs during the interictal period relative to healthy controls showed signi cantly slower RTs on incongruent trials during the Stroop interference test without a between-group difference in commited errors (37,48). Given that the Stroop interference test measured cognitive interference or inhibition (26), the behavioral nding in the present study indicates that the impairment in inhibitory control in migraineurs can occur not only during the early and intermediate stage of information processing, but also during the late stage of information processing, such as response execution.…”

Section: Discussionsupporting

confidence: 90%

Response inhibition alterations in migraine: An event-related potential study

Chen¹,

Y²,

Zhao³

et al. 2020

Preprint

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Background Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mechanisms giving rise to this abnormality, the presence of deficient inhibitory cortical processes has been proposed to be one possible mechanism underlying its pathogenesis. Empirical evidence supporting this notion is mainly based on previous findings showing functional cortical hyperexcitability in the sensory domain. Considering that a general inhibitory control process can play an important role across early to later stage of information processing, this may in turn indicate the important role other dimensions of inhibitory control can play in migraine disability. To this end, the present study was designed to examine the pathophysiological basis of inhibitiory control that takes place during suppression of prepotent responses. Methods Twenty-two patients with migraine without aura (mean age = 30.86 ± 5.69 years; 19 females) during the interictal period and 25 healthy controls (mean age = 30.24 ± 3.52 years; 18 females) were recruited. We employed a stop signal task in combination with event-related potentials (ERPs) to examine participants’ neural activity supporting response inhibition. Results Behaviorally, migraineurs exhibited prolonged reaction times to the stop signal relative to healthy controls. At the neural level, the amplitude of the stop-N2, a component of the ERPs related to conflict monitoring during early, non-motoric stages of inhibition, was significantly increased in migraineurs. Meanwhile, the amplitude of the stop-P3, a component of the ERPs reflecting late-stage inhibition of the motor system itself and cognitive evaluation of motor inhibition, was also significantly increased in migraineurs. Moreover, our time-frequency analysis has further revealed increased delta activity in the time window used to extract the mean amplitude of the stop-P3 in migraineurs relative to healthy controls. Conclusions Consistent with the theory that cortical hyperexcitability is a key signature of migraine, these findings revealed a decrease in suppressing prepotent responses in migraineurs, which can be attributable to cortical hyperexcitability. These novel findings imply the existence of dysfunctional inhibitory control at later stage of information processing.

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Section: Discussionsupporting

confidence: 90%

Response inhibition alterations in migraine: An event-related potential study

Chen¹,

Y²,

Zhao³

et al. 2020

Preprint

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“…FNIRS detects the changes in light absorption and scattering in tissue caused by changes in concentration of oxyhemoglobin (∆HbO) and deoxyhemoglobin (∆Hb) secondary to neuronal activity, through a neurovascular coupling mechanism that is currently under investigation [17]. Though fNIRS can measure the slow hemodynamic response elicited by neuronal activity that correlates with corresponding fMRI measurements [5], it is often the case that the activation signal-to-noise ratio (SNR) in fNIRS is low due to poor optical contact between the optical fibers that deliver and collect near infrared (NIR) light to and from the scalp [18].…”

Section: Introductionmentioning

confidence: 99%

Improving optical contact for functional near‑infrared brain spectroscopy and imaging with brush optodes

Khan¹,

Wildey²,

Francis³

et al. 2012

Biomed. Opt. Express

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A novel brush optode was designed and demonstrated to overcome poor optical contact with the scalp that can occur during functional near infrared spectroscopy (fNIRS) and imaging due to light obstruction by hair. The brush optodes were implemented as an attachment to existing commercial flat-faced (conventional) fiber bundle optodes. The goal was that the brush optodes would thread through hair and improve optical contact on subjects with dense hair. Simulations and experiments were performed to assess the magnitude of these improvements. FNIRS measurements on 17 subjects with varying hair colors (blonde, brown, and black) and hair densities (0–2.96 hairs/mm2) were performed during a finger tapping protocol for both flat and brush optodes. In addition to reaching a study success rate of almost 100% when using the brush optode extensions, the measurement setup times were reduced by a factor of three. Furthermore, the brush optodes enabled improvements in the activation signal-to-noise ratio (SNR) by up to a factor of ten as well as significant (p < 0.05) increases in the detected area of activation (dAoA). The measured improvements in SNR were matched by Monte Carlo (MC) simulations of photon propagation through scalp and hair. In addition, an analytical model was derived to mathematically estimate the observed light power losses due to different hair colors and hair densities. Interestingly, the derived analytical formula produced excellent estimates of the experimental data and MC simulation results despite several simplifying assumptions. The analytical model enables researchers to readily estimate the light power losses due to obstruction by hair for both flat-faced fiber bundles and individual fibers for a given subject.

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“…[45][46][47][48] fNIRS detects changes in light absorption and scattering in tissue caused by fluctuations in oxy-hemoglobin (HbO) and deoxyhemoglobin (Hb) concentrations secondary to neuronal activity, known as neurovascular coupling. 49,50 It has also been shown that fNIRS is able to detect event-related optical signals, which occur within hundreds of milliseconds and correlate with evoked potentials measured by simultaneous electroencephalography (EEG), 51,52 are much faster than the seconds resolution of fMRI. 53,54 Recently, fNIRS detected changes in resting state HbO after anodal tDCS was applied to the prefrontal cortex, 55 though no fNIRS studies to date have explored the effects of tDCS on functional activation patterns in the sensorimotor cortex, which is the focus of this work.…”

mentioning

confidence: 99%

Functional near-infrared spectroscopy maps cortical plasticity underlying altered motor performance induced by transcranial direct current stimulation

et al. 2013

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Abstract. Transcranial direct current stimulation (tDCS) of the human sensorimotor cortex during physical rehabilitation induces plasticity in the injured brain that improves motor performance. Bi-hemispheric tDCS is a noninvasive technique that modulates cortical activation by delivering weak current through a pair of anodal-cathodal (excitation-suppression) electrodes, placed on the scalp and centered over the primary motor cortex of each hemisphere. To quantify tDCS-induced plasticity during motor performance, sensorimotor cortical activity was mapped during an event-related, wrist flexion task by functional near-infrared spectroscopy (fNIRS) before, during, and after applying both possible bi-hemispheric tDCS montages in eight healthy adults. Additionally, torque applied to a lever device during isometric wrist flexion and surface electromyography measurements of major muscle group activity in both arms were acquired concurrently with fNIRS. This multiparameter approach found that hemispheric suppression contralateral to wrist flexion changed resting-state connectivity from intra-hemispheric to inter-hemispheric and increased flexion speed (p < 0.05). Conversely, exciting this hemisphere increased opposing muscle output resulting in a decrease in speed but an increase in accuracy (p < 0.05 for both). The findings of this work suggest that tDCS with fNIRS and concurrent multimotor measurements can provide insights into how neuroplasticity changes muscle output, which could find future use in guiding motor rehabilitation. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Intact neurovascular coupling during executive function in migraine without aura: Interictal near-infrared spectroscopy study

Cited by 26 publications

References 66 publications

Response inhibition alterations in migraine: An event-related potential study

Response inhibition alterations in migraine: An event-related potential study

Improving optical contact for functional near‑infrared brain spectroscopy and imaging with brush optodes

Functional near-infrared spectroscopy maps cortical plasticity underlying altered motor performance induced by transcranial direct current stimulation

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