Intact regulation of protein intake during the development of hypothalamic or genetic obesity in rats

Anderson, G. Harvey; Leprohon, Carol E.; Chambers, John W.; Coscina, Donald V.

doi:10.1016/0031-9384(79)90170-7

Cited by 36 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The appetite for these historically scarce (and widely desired) materials is ingrained in our brain in an atavistic way [83], comparable perhaps to a number of phobias (spiders, snakes) that we also inherited from our early ancestors. Unlike protein [84,85] (and largely sugars [86,87] we have not developed mechanisms controlling the eventual excessive intake of lipid. Consequently, our ancestors of less than a hundred generations, ate no more than 20% of their energy needs as lipids, and about 10-12% protein (mostly low-quality and plant-derived), with a limited contribution of sugars (fruit) and no added salt (except in seafaring cultures) [88].…”

Section: Introductionmentioning

confidence: 99%

Different effects of hyperlipidic diets in human lactation and adulthood: growth versus the development of obesity

Alemany

2011

Reprod Biol Endocrinol

View full text Add to dashboard Cite

After birth, the body shifts from glucose as primary energy substrate to milk-derived fats, with sugars from lactose taking a secondary place. At weaning, glucose recovers its primogeniture and dietary fat role decreases. In spite of human temporary adaptation to a high-fat (and sugars and protein) diet during lactation, the ability to thrive on this type of diet is lost irreversibly after weaning. We could not revert too the lactating period metabolic setting because of different proportions of brain/muscle metabolism in the total energy budget, lower thermogenesis needs and capabilities, and absence of significant growth in adults. A key reason for change was the limited availability of foods with high energy content at weaning and during the whole adult life of our ancestors, which physiological adaptations remain practically unchanged in our present-day bodies. Humans have evolved to survive with relatively poor diets interspersed by bouts of scarcity and abundance. Today diets in many societies are largely made up from choice foods, responding to our deeply ingrained desire for fats, protein, sugars, salt etc. Consequently our diets are not well adjusted to our physiological needs/adaptations but mainly to our tastes (another adaptation to periodic scarcity), and thus are rich in energy roughly comparable to milk. However, most adult humans cannot process the food ingested in excess because our cortical-derived craving overrides the mechanisms controlling appetite. This is produced not because we lack the biochemical mechanisms to use this energy, but because we are unprepared for excess, and wholly adapted to survive scarcity. The thrifty mechanisms compound the effects of excess nutrients and damage the control of energy metabolism, developing a pathologic state. As a consequence, an overflow of energy is generated and the disease of plenty develops.

show abstract

Section: Introductionmentioning

confidence: 99%

Different effects of hyperlipidic diets in human lactation and adulthood: growth versus the development of obesity

Alemany

2011

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

Macronutrient Selection in Experimental Animals

Kanarek

2000

CP Neuroscience

View full text Add to dashboard Cite

To address the question of how animals choose diets from an array of nutritionally different foods, researchers have designed experiments in which animals are provided with separate sources of the three macronutrients, protein, fat and carbohydrate. These experiments are useful for investigating the neuroanatomical and neurochemical mechanisms involved in food choice, as well as for assessing the effects of changes in physiological status (e.g., pregnancy; lactation and increased energy expenditure) or disease states (e.g., diabetes; and obesity) on nutrient intakes.

show abstract

Macronutrient Selection in Experimental Animals

Kanarek

2004

CP Neuroscience

View full text Add to dashboard Cite

show abstract

Intact regulation of protein intake during the development of hypothalamic or genetic obesity in rats

Cited by 36 publications

References 20 publications

Different effects of hyperlipidic diets in human lactation and adulthood: growth versus the development of obesity

Different effects of hyperlipidic diets in human lactation and adulthood: growth versus the development of obesity

Macronutrient Selection in Experimental Animals

Macronutrient Selection in Experimental Animals

Contact Info

Product

Resources

About