Intact versus Fragmented ^99mTc-Monoclonal Antibody Imaging of Infection in Patients with Septically Loosened Total Knee Arthroplasty

Abstract

Both 99mTc-besilesomab and 99mTc-sulesomab had similar diagnostic accuracy for the detection of septic arthroplasty. If repeated use of immunoscintigraphy is needed for follow-up, 99mTc-sulesomab should be preferred over 99mTc-besilesomab since it is known to be well tolerated and without side effects or incompatibility reactions.

Use of Anti-Granulocyte Scintigraphy with 99mTc-Labeled Monoclonal Antibodies for the Diagnosis of Periprosthetic Infection in Patients after Total Joint Arthroplasty: A Diagnostic Meta-Analysis

“…A total of 246 titles and abstracts were preliminarily reviewed, of which 19 studies [4], [27]–[44] eventually satisfied the eligibility criteria. Figure 1 shows a flow diagram of the selection process.…”

Leukocyte and bacteria imaging in prosthetic joint infection

“…Imaging prosthetic joint infection (sulesomab) found similar diagnostic accuracy rates for the detection of septically loosened total knee arthroplasty (Gratz et al, 2012). 18 F-FDG is a radiopharmaceutical for PET imaging, used for many years in oncology, but it can also be used in infectious diseases because activated leukocytes use glucose as an energy source after activation.…”

Imagerie scintigraphique de l’infection des prothèses de hanche et de genou

“…Graute et al ont publié des résultats avec une sensibilité supérieure de la technique en ajoutant l'exploration hybride dans le diagnostic des infections évoluant à bas bruit [40]. Une seule étude à notre connaissance a évalué les deux techniques dans le diagnostic d'infection de PTG avec un faible effectif de patients ne montrant pas de différence entre les deux traceurs [41].…”