Intake and distribution of doxycycline in the organism of broiler chickens

Abstract

The article presents the results of studies on the absorption, distribution and excretion of the antibiotic Poledoxin (the active substance is doxycycline hyclact) from the body of healthy broiler chickens of the Koob-500 cross when taken orally. Studies have established the rapid absorption of doxycycline hyclact from the digestive tract of the chicken into the blood and its entry into the internal organs. The maximum concentration of doxycycline hyclact was detected 2-4 hours after the start of Poledoxin administration, the content of which in the liver was 9,07±0,07 μg/g, in the lungs – 8,39±0,20 μg/g, in the heart – 4,24±0,09 μg/g, in the pectoral muscles – 4,28±0,23 μg/g. In the kidneys, the maximum concentration was found after 12 hours – 7,63±0,38 μg/g. When clinically healthy broiler chickens were fed with Poledoxin solution, the ability to materially cumulate doxycycline hyclact (active ingredient) was not established, since its content in the internal organs and muscles of the bird did not depend on the duration of the drug use. Studies have established the absence of organ affiliation of doxycycline hyclact, because its maximum content, depending on the study period, was recorded in various organs that provide biotransformation and excretion – liver, kidneys, lungs. The cancellation of drinking Poledoxin ensured the rapid elimination of doxycyclin hyclact from the body of broiler chickens and, after 5 days (for 216 hours of the experiment), its content was minimal for the entire study period and amounted to: in the kidneys – 0,15±0,01 μg/g; liver – 0,12±0,01 μg/g; pectoral muscles – 0,05±0,01 μg/g; lungs – 0,04±0,01 μg/g. Only in one sample of the heart, doxycycline hyclact was shown in an amount of 0,01 μg/g. Key words: Poledoxin, doxycycline hyclact, broiler chickens, distribution, accumulation, hatching, bioavailability, pharmacokinetics, excretion.

Doxycycline Intake and Distribution in the Body of Broiler Chickens With Ornithobacteriosis

“…After discontinuation of feeding a pollodoxin solution, the content of doxycycline hyclate in the internal organs decreases intensively, which indicates its biotransformation and excretion from the body (Table 1). Thus, 24 hours after discontinuation of pollodoxin (120 hours of the experiment) the content of doxycycline hyclate was lower than 96 hours: in the lungs -3.4 times, pectoral muscles -2.9 times, kidneys -2.5 times, liver and heart -2.4 times (Kramer et al, 1978;Anadón, et al, 1994;Croubels et al, 1998;Gajda et al, 2014;Widyasari-Mehta et al, 2016;Mestorino et al, 2018;Tyshkivska et al, 2020).…”