Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis

Murakami, Isao; Murakami, Kosaku; Hashimoto, Motomu; Tanaka, Masao; Ito, Hiromu; Fujii, Tomoyuki; Torii, Mie; Ikeda, Kaori; Kuwabara, Akiko; Tanaka, Kiyoshi; Yoshida, Akira; Akizuki, Shuji; Nakashima, Ran; Yoshifuji, Hajime; Ohmura, Koichiro; Usui, Takashi; Morita, Satoshi; Mimori, Tsuneyo

doi:10.1371/journal.pone.0228852

Cited by 11 publications

(16 citation statements)

References 26 publications

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“…Dietary habits of RA patients were obtained from the self-reported questionnaire as described previously 14 , 18 . This questionnaire consisted of 20 items about the intake frequency of 1. staple food (rice, bread or noodles) for breakfast, 2. staple food for lunch, 3. staple food for dinner, 4. meat, 5. fish, 6. tofu (soybean curd), 7. eggs, 8. milk, 9. vegetables, 10. fruits, 11. deep-fried foods, 12. cakes, 13. juice or isotonic drinks, 14. junk foods, 15. sweets like candies and chocolates, 16. frozen foods, 17. pickles, 18. ham, sausage or kamaboko (boiled fish paste), 19. miso soup (fermented soybean paste) and by the participants.…”

Section: Methodsmentioning

confidence: 99%

“…Nutritional interventions such as protein supplementation were found to improve physical function of the frail elderly in several clinical trials 13 . In the RA population, seafood, fruits and vegetables have beneficial effects on disease activity 14 , whereas high-fat diets have the opposite effect by leading to a pro-inflammatory response 15 . Even though several nutrients are expected to have therapeutic effects both on frailty and inflammatory diseases, clinical correlations between dietary habits and frailty with RA have not been examined.…”

Section: Introductionmentioning

confidence: 99%

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Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis

Minamino

Katsushima

Torii

et al. 2021

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Frailty is a geriatric syndrome characterized by anabolic-catabolic imbalance and multisystem dysregulation resulting in increased adverse health outcomes, and is closely related with dietary habits in the general population. Although chronic inflammatory diseases are thought to accelerate development of frailty, correlations between rheumatoid arthritis (RA), frailty and dietary habits have not been examined. We performed a cross-sectional study using our cohort database (KURAMA cohort), and classified 306 participants into three groups (robust, prefrail and frail) according to the Study of Osteoporotic Fracture (SOF) criteria. Multivariate logistic analysis revealed that the presence of frailty/prefrailty was significantly correlated with the disease activity score (DAS28-ESR) (OR 1.70 (1.30–2.22), p < 0.0001). Additional analyses of frailty and food intake showed that 5 foods (fish, meat, milk, vegetables and fruits) of 20 groups on the questionnaire were inversely associated with the prevalence of frail/prefrail categories. In multivariate analysis with the five nutrients, fish intake (> two times a week) was an independent covariate negatively correlated with frailty/prefrailty (OR 0.35 (0.19–0.63), p = 0.00060). In conclusion, habitual fish intake may play a key role in nutritional intervention to prevent progression of frailty and RA.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis

Minamino

Katsushima

Torii

et al. 2021

Sci Rep

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“…In addition, a pilot study has shown that potassium supplementation improves joint pain in RA patients with hypokalemia [37]. Moreover, our group has previously reported that potassium-rich ingredients such as fruits and vegetables are signi cantly associated with lower RA disease activity [38]. In summary, the urinary Na/K ratio is an independent disease activity marker of RA, and increased Na intake and decreased K intake may contribute to RA pathogenesis.…”

Section: Discussionmentioning

confidence: 91%

Urinary Sodium-To-Potassium Ratio Is A Dual Indicator Of Hypertension And Current Disease Activity In Patients With Rheumatoid Arthritis: A Cross-Sectional Study In The KURAMA Cohort Database

Minamino

Katsushima

Hashimoto

et al. 2020

Preprint

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Background: Excessive salt intake is thought to exacerbate both development of hypertension and autoimmune diseases in animal models, but the clinical impact of excessive salt in rheumatoid arthritis (RA) patients is still unknown. We performed a cross-sectional study to clarify the associations between salt load index (urinary sodium-to-potassium ratio (Na/K ratio)), current disease activity and hypertension in an RA population.Methods: Three hundred thirty-six participants from our cohort database (KURAMA) were enrolled. We used the spot urine Na/K ratio as a simplified index of salt loading, and used the 28-Joint RA Disease Activity Score (DAS28-ESR) as an indicator of current RA disease activity. Using these indicators, we evaluated statistical associations between urinary Na/K ratio, DAS28-ESR and prevalence of hypertension.Results: Urinary Na/K ratio was positively associated with measured systolic and diastolic blood pressure and also with prevalence of hypertension even after covariate adjustment (OR 1.30, p < 0.001). In addition, increased urinary Na/K ratio was significantly and positively correlated with DAS28-ESR in multiple regression analysis (estimate 0.12, p < 0.001), as was also the case in gender-separated and prednisolone-separated sub-analyses.Conclusion: Urinary Na/K ratio was independently associated with current disease activity as well as with prevalence of hypertension in RA patients. Thus, dietary modifications such as salt restriction and potassium supplementation may well attenuate both disease activity and hypertension in RA patients.

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“…The analyses in the current study were conducted using the Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort database, with approval from the ethics committee of Kyoto University Hospital. The KURAMA cohort was established in May 2011 at the Center for Rheumatic Disease at Kyoto University Hospital with the aims of providing strict control of RA and using patient clinical and laboratory data for clinical investigations [11][12][13]. Clinical, biological and functional data were recorded at baseline and every visit.…”

Section: Patientsmentioning

confidence: 99%

Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort

Murata¹,

Ito²,

Hashimoto³

et al. 2020

Arthritis Res Ther

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Background The positivity of anti-citrullinated protein/peptide antibodies (ACPAs) is a clinically useful diagnostic and prognostic marker in rheumatoid arthritis (RA). However, the significance of ACPA titer and its fluctuation remain unclear. This study aimed to assess the role of ACPA titer and its fluctuation on disease activity and the prognosis of RA. Methods Data obtained from the Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort was analyzed. Patients whose ACPA was measured at least twice between 2011 and 2019 and whose ACPA was positive at least once were included in this study. The association between the clinical variable and ACPA titer or its change was investigated. Results ACPA titer was measured in a total of 3286 patients, 1806 of whom were ACPA-positive at least once. Among them, the ACPA titer level was measured more than once in 1355 patients. Very weak correlation was observed between the ACPA titer level and disease activity. Additionally, there was no trend in the fluctuation of ACPA titer level in each patient; ACPA titer level fluctuated in some patients, but not in others. Patients with high variable levels of ACPA titer were more likely to relapse from remission. In the analysis of two consecutive ACPA measurements, the titer changes predicted the relapse from remission within a year of the second measurement. Conclusions The ACPA titer level fluctuated in some patients. Very weak correlation was observed between the ACPA titer level and disease activity. Fluctuation in ACPA titer level predicted relapse from remission in patients with RA.

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Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis

Cited by 11 publications

References 26 publications

Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis

Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis

Urinary Sodium-To-Potassium Ratio Is A Dual Indicator Of Hypertension And Current Disease Activity In Patients With Rheumatoid Arthritis: A Cross-Sectional Study In The KURAMA Cohort Database

Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort

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