Intake of Alcohol May Modify the Risk for Non-Melanoma Skin Cancer: Results of a Large Danish Prospective Cohort Study

Jensen, Allan; Birch-Johansen, Fatima; Olesen, Anne Braae; Christensen, Jane; Tjønneland, Anne; Kjær, Susanne K.

doi:10.1038/jid.2012.198

Cited by 27 publications

(52 citation statements)

References 22 publications

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“…In accordance with three large cohort studies (Fung et al , 2002; Freedman et al , 2003; Jensen et al , 2012), we observed an elevated BCC risk in alcohol drinkers. Several mechanisms have been suggested to explain how alcohol may initiate and promote skin carcinogenesis.…”

Section: Discussionsupporting

confidence: 92%

Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities

et al. 2014

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Background:Little is known about the epidemiology of basal cell carcinoma (BCC).Methods:Using the Clinical Practice Research Datalink, we calculated annual incidence rates. In a case–control analysis, we examined lifestyle factors and comorbidities.Results:Incidence rose significantly between 2000 and 2011. Basal cell carcinoma risk was increased in alcohol drinkers (slightly) and immunocompromised patients, but reduced in smokers and individuals with abnormal weight.Conclusions:Basal cell carcinoma places a growing public health burden. Lifestyle factors do not play a major role in pathogenesis, but immunosuppression is important.

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Section: Discussionsupporting

confidence: 92%

Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities

et al. 2014

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“…Although Jensen et al [16] did not find an association between risk of basal cell carcinoma and squamous cell carcinoma and overall alcohol intake in a cohort of Danish men and women, they did find an increasing hazard for BCC for wine consumption and liquor consumption. This is similar to our finding of an increased risk for NMSC for liquor and white wine preference compared to non-drinkers.…”

Section: Discussionmentioning

confidence: 89%

Alcohol consumption and risk of melanoma and non-melanoma skin cancer in the Women’s Health Initiative

Kubo

Henderson

Desai

et al. 2013

Cancer Causes Control

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Purpose The relationship between alcohol consumption and preference of alcohol type with hazard of melanoma (MM) and risk of non-melanoma skin cancer (NMSC) was examined in the Women's Health Initiative (WHI) Observational Study (OS). Methods A prospective cohort of 59,575 White postmenopausal women in the WHI OS (mean age 63.6) was analyzed. Cox proportional hazards models and logistic regression techniques were used to assess the hazard and risk of physician-adjudicated MM and self-reported NMSC, respectively, after adjusting for potential confounders including measures of sun exposure and skin type. Results Over 10.2 mean years of follow-up, 532 MM cases and 9,593 NMSC cases occurred. A significant relationship between amount of alcohol consumed and both MM and NMSC was observed, with those who consume 7+ drinks per week having a higher hazard of MM (HR 1.64 (1.09, 2.49), pglobal = 0.0013) and higher risk of NMSC (OR 1.23 (1.11, 1.36), pglobal < 0.0001) compared to non-drinkers. Lifetime alcohol consumption was also positively associated with hazard of MM (p = 0.0011) and risk of NMSC (p < 0.0001). Further, compared to non-drinkers, a preference for either white wine or liquor was associated with an increased hazard of MM (HR 1.52 (1.02, 2.27) for white wine; HR 1.65 (1.07, 2.55) for liquor) and risk of NMSC (OR 1.16 (1.05, 1.28) for white wine; OR 1.26 (1.13, 1.41) for liquor). Conclusions Higher current alcohol consumption, higher lifetime alcohol consumption, and a preference for white wine or liquor were associated with increased hazard of MM and risk of NMSC.

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“…Furthermore, given that the development of skin cancer depends on both sun exposure and constitutional factors, it is possible that sun exposure may interact with host risk profile to alter an individual's skin cancer risk. More recent studies also revealed that lifestyle-related factors, such as artificial tanning bed use (17-19), weight change (20,21), smoking (22,23), alcohol intake (24,25), physical activity (26,27), and rotating nights shifts (28), may also modify risks of different skin cancers. Currently a comprehensive assessment is lacking for the relationships between chronic sun exposure based on residential history, as well as sun exposure in early life, and risk of different types of skin cancer.…”

mentioning

confidence: 99%

Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study

Han

Laden

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

139

111

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Background Few prospective studies have examined the relationship between sun exposure, other potential risk factors, and risk of different skin cancers [including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma] simultaneously. Methods We evaluated the association between a number of potential risk factors and skin cancer risk in a cohort of 108,916 US women, the Nurses’ Health Study II (1989-2009). Results During 2.05 million years of follow-up, we identified 6,955, 880, and 779 diagnoses of BCC, SCC, and melanoma, respectively. Compared to participants in the lowest quintile of cumulative ultraviolet flux in adulthood, participants in the highest quintile had multivariable-adjusted relative risks (RR) of 2.35 (Ptrend<0.0001) for BCC, 2.53 (Ptrend=0.009) for SCC, and 0.68 (Ptrend=0.38) for melanoma. In contrast, the RRs were 1.68 (95%CI: 1.55-1.82) for BCC, 1.68 (95%CI: 1.34-2.11) for SCC and 1.80 (95%CI: 1.42-2.28) for melanoma for participants with ≥5 blistering sunburns when compared to participants without sunburn between ages 15-20. We found significant interactions between family history of melanoma, number of blistering sunburns between ages 15-20 and BCC risk, and between sunburn reaction as a child/adolescent and SCC risk (all Pinteraction<0.05). Conclusion In a cohort of US women, we found that sun exposures in both early life and adulthood were predictive of BCC and SCC risks, whereas melanoma risk was predominantly associated with sun exposure in early life. Impact Our results may have potential implications for the prevention of skin cancers.

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Intake of Alcohol May Modify the Risk for Non-Melanoma Skin Cancer: Results of a Large Danish Prospective Cohort Study

Cited by 27 publications

References 22 publications

Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities

Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities

Alcohol consumption and risk of melanoma and non-melanoma skin cancer in the Women’s Health Initiative

Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study

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