Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle‐Aged Rats by Suppressing the Glycosylation Process

Ma, Yafang; Zhou, Guanghong; Li, Yingqiu; Zhu, Yingying; Yu, Xiaobo; Fan, Zhanming; Li, He

doi:10.1002/mnfr.201700661

Cited by 13 publications

(9 citation statements)

References 53 publications

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“…We next examined markers involved in mucin glycosylation that have been shown to be altered by dietary factors. 55–59 In particular, we focused on the glycosyltransferases that are suggested to correlate with the Muc2 glycosylation. 36 Surprisingly, we discovered that the supplementation with FOS significantly modulated the expression of many glycosyltransferases in the jejunum, ileum, cecum and colon.…”

Section: Discussionmentioning

confidence: 99%

Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion

et al. 2022

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Obesity is a major risk factor for the development of type 2 diabetes and cardiovascular diseases, and gut microbiota plays a key role in influencing the host energy homeostasis. Moreover, obese mice have a different gut microbiota composition, associated with an alteration of the intestinal mucus layer, which represents the interface between the bacteria and the host. We previously demonstrated that prebiotic treatment with oligofructose (FOS) counteracted the effects of diet-induced obesity, together with changes in the gut microbiota composition, but it is not known if the intestinal mucus layer could be involved. In this study, we found that, in addition to preventing high-fat diet (HFD) induced obesity in mice, the treatment with FOS increased the expression of numerous genes involved in mucus production, glycosylation and secretion, the expression of both secreted and transmembrane mucins, and the differentiation and number of goblet cells. These results were associated with significant changes in the gut microbiota composition, with FOS significantly increasing the relative and absolute abundance of the bacterial genera Odoribacter, Akkermansia , two unknown Muribaculaceae and an unknown Ruminococcaceae . Interestingly, all these bacterial genera had a negative association with metabolic parameters and a positive association with markers of the mucus layer. Our study shows that FOS treatment is able to prevent HFD-induced metabolic disorders, at least in part, by acting on all the processes of the mucus production. These data suggest that targeting the mucus and the gut microbiota by using prebiotics could help to prevent or mitigate obesity and related disorders.

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Section: Discussionmentioning

confidence: 99%

Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion

et al. 2022

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“…The significant higher TLR4 and MyD88 expression level in the ileum tissue in PO and LO groups also indicated their higher pro-inflammatory effects. However, the inflammation was a complex process of gradually developing pathology (Ma et al, 2018), thus the downstream inflammatory cytokines, such as the NFκβ and TNFα in the TLR signal pathway did not show significant change.…”

Section: F I G U R Ementioning

confidence: 97%

Influence of different dietary oil consumption on nutrient malabsorption: An animal trial using Sprague Dawley rats

Liu

2021

J. Food Biochem.

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In the present study, the influences of five typical dietary oils (i.e., palm oil, PO; leaf lard oil, LO; rapeseed oil, RO; sunflower oil, SO; and linseed oil, LN) consumption on the nutrients malabsorption were studied using adult male Sprague Dawley rats.Results suggested that the C16:0 (24.534 ± 2.26% to 54.269 ± 1.28%) and C18:0 (18.433 ± 4.421% to 36.455 ± 3.316%) were the dominant fatty acids in fecal samples in different groups. After 6-week intervention by different dietary oils, the fecal moisture and water soluble protein content in PO group, the reducing sugar content in PO, LO, and RO groups were significantly increased compared with those in the control group (p < .05). Moreover, the Na, K, and Fe contents in LO group were all the highest among the all groups. These effects were probably due to the different fatty acids composition as illustrated in the correlation analysis results. The different effects were probably due to their distinct fatty acids composition as illustrated in the correlation analysis results. Results further indicated that the different dietary oils treatment, especially for the PO (SFAs, 43.17 ± 0.98%) and LO (SFAs, 36.44 ± 0.65%), increased the upstream inflammatory cytokine expression level in the Toll-like receptor signal pathway (i.e., TLR4 and MyD88), enhancing the gut permeability. This resulted in significant increase of serum lipopolysaccharide (LPS) levels (p < .05), which was closely connected with different metabolic diseases. The present study may provide basic understandings about different dietary oil enteral nutrition and their effects on gut health. Practical applicationsThe PO, LO, RO, SO, and LN are the five of the most typical dietary lipids in Asia countries, especially in China. They are the natural edible oils which are rich in C16:0, C18:0, C18:1, C18:2ω6, and C18:3ω3, respectively. The present study indicated that the different dietary lipid consumption may result in different dietary nutrients malabsorption, which are related with the dietary lipid fatty acid composition. K E Y W O R D Sdietary oil, enteral nutrition, fatty acids, gut health, nutrients malabsorption Highlights 1. Fecal fatty acid profiles in different dietary oil-treated groups were different.2. There were connections between fatty acid composition and nutrients malabsorption.3. Different dietary oils treatment increased the gut permeability, enhancing the serum LPS level.4. Expression level of the inflammatory cytokines in TLR signal pathway upstream increased, especially for oils rich in SFAs.

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“…[88] However, at a moderate dosage (4% w/w), a fish fat diet, but not pork fat, induced higher relative abundances of Desulfovibrionaceae and Bilophila and induced damage to the gut mucosa barrier in the colon. [89,90] The metabolites of Desulfovibrionaceae and Bilophila may cause metabolic disorders and endotoxemia that contribute to pathogen adherence to the intestinal wall, impair intestinal barrier function, and increase risk of inflammation. In contrast, no metabolic disorders were observed in response to a moderate intake of a lard-based diet.…”

Section: Fat and Gut Microbiotamentioning

confidence: 99%

Reconsidering Meat Intake and Human Health: A Review of Current Research

Xie

Cai

et al. 2022

Molecular Nutrition Food Res

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Meat consumption is gradually increasing and its impact on health has attracted widespread attention, resulting in epidemiological studies proposing a reduction in meat and processed meat intake. This review briefly summarizes recent advances in understanding the effects of meat or processed meat on human health, as well as the underlying mechanisms. Meat consumption varies widely among individuals, populations, and regions, with higher consumption in developed countries than in developing countries. However, increasing meat consumption may not be the main cause of increasing incidence of chronic disease, since the development of chronic disease is a complex physiological process that involves many factors, including excessive total energy intake and changes in food digestion processes, gut microbiota composition, and liver metabolism. In comparison, unhealthy dietary habits and a sedentary lifestyle with decreasing energy expenditure are factors more worthy of reflection. Meat and meat products provide high‐value protein and many key essential micronutrients. In short, as long as excessive intake and overprocessing of meats are avoided, meat remains an indispensable source of nutrition for human health.

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Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle‐Aged Rats by Suppressing the Glycosylation Process

Cited by 13 publications

References 53 publications

Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion

Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion

Influence of different dietary oil consumption on nutrient malabsorption: An animal trial using Sprague Dawley rats

Reconsidering Meat Intake and Human Health: A Review of Current Research

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