Intake of Flavonoids, Carotenoids, Vitamins C and E, and Risk of Stroke in Male Smokers

Hirvonen, Tero; Virtamo, Jarmo; Korhonen, Pasi; Albanês, Demetrius; Pietinen, Pirjo

doi:10.1161/01.str.31.10.2301

Cited by 192 publications

(167 citation statements)

References 29 publications

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“…Generally, risk of stroke has not been as strongly associated with dietary and lifestyle factors as has risk of CHD, despite the association of incidence of stroke with hypertension and serum lipid abnormalities (Leys et al, 2002). Some studies have reported lower risk of ischemic stroke with higher consumption of green leafy vegetables (Joshipura et al, 1999;Johnsen et al, 2003;Sauvaget et al, 2003) or with higher consumption of total vegetables (Hirvonen et al, 2000). However, this association has not always been independent of known CVD risk factors (Johnsen et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women

Erkkilä

Booth

et al. 2004

Eur J Clin Nutr

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Objective: To examine the feasibility of using phylloquinone intake as a marker for coronary heart disease (CHD) and stroke risk in women. Design and setting: Nurses' Health Study, a prospective cohort study during 1984-2000 . Dietary data were collected in 1984, 1986 , 1990, and 1994 using a validated semiquantitative food frequency questionnaire. Subjects: A total of 72 874 female nurses, aged 38-65 y, without previously diagnosed angina, myocardial infarction (MI), stroke, or cancer at baseline. Main outcome measures: Incidence of nonfatal MI, CHD deaths, total CHD events, ischemic, and total strokes. Results: There were 1679 CHD events (1201 nonfatal) and 1009 strokes (567 ischemic). After adjustment for age and lifestyle factors associated with cardiovascular disease risk, the multivariate relative risks (RR) (95% CI) of total CHD from the lowest to the highest quintile category of phylloquinone intake were 1 (reference), 0.80 (0.69-0.94), 0.86 (0.74-1.00), 0.77 (0.66-0.99), and 0.79 (0.68-0.92), P for trend ¼ 0.01. Further adjustment for dietary intakes of saturated fat, polyunsaturated fat, trans fatty acids, eicosapentaenoic, and docosahexaenoic acids, cereal fiber, and folate attenuated the association (RR comparing extreme quintiles 0.84 [0.71-1.00], P for trend ¼ 0.12). Incidence rates of total or ischemic strokes were not associated with phylloquinone intake. Conclusion: The data suggest that high phylloquinone intake may be a marker for low CHD risk. Dietary and lifestyle patterns associated with phylloquinone intakes, rather than intake of the nutrient itself, might account for all or part of the weak association. Sponsorship:

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Section: Discussionmentioning

confidence: 99%

Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women

Erkkilä

Booth

et al. 2004

Eur J Clin Nutr

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“…Their wide distribution throughout the plant kingdom results in their inevitable presence in diets rich in plant-derived foods or beverages, where they appear to contribute to the overall health benefits of consuming such a diet. The epidemiological link of flavonoid intake to prevention of diabetes appears to be the strongest thus far (Nicolle et al, 2011), however specific links of flavonoid intake to cardiovascular mortality, chronic inflammation, cancer and other conditions are also evident (Arab and Liebeskind, 2010;Hirvonen et al, 2000;Manthey, 2000;Mink et al, 2007;Steinmetz and Potter, 1996).…”

Section: Introduction: C-glycosylation Of Flavonoidsmentioning

confidence: 99%

The Occurrence, Fate and Biological Activities ofC-glycosyl Flavonoids in the Human Diet

Courts

Williamson

2013

Critical Reviews in Food Science and Nutrition

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“…Several studies have suggested that dietary antioxidants may play a protective role against the development of subarachnoid hemorrhage (SAH) (Marzatico et al, 1998;Leppala et al, 1999Leppala et al, , 2000Hirvonen et al, 2000;Kaynar et al, 2005;Okamoto, 2006;Okamoto and Horisawa, 2006). In general, various dietary antioxidants may be interactive or synergistic rather than isolated.…”

Section: Introductionmentioning

confidence: 99%

Dietary antioxidant intake and risk of an aneurysmal rupture subarachnoid hemorrhage in Japan

Okamoto

Horisawa

2007

Eur J Clin Nutr

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The purpose of this study was to investigate the relationship between dietary antioxidant intake and the risk of subarachnoid hemorrhage (SAH) in a case-control study. An antioxidant intake score was calculated for individual values for each food group (soy products, green yellow-vegetables, fruits, boiled rice and tea) collected by a self-administered food frequency questionnaire. Incident SAH cases (n ¼ 201) were identified and individually matched for age (72 years) and gender to community (n ¼ 201) controls from April 1992 to March 1997. The antioxidant intake score was inversely associated with the risk of SAH, even after adjusting for confounding factors (lowest vs highest score adjusted odds ratio, 0.54; 95% confidence interval, 0.30-0.99). These findings suggest that the development of SAH may be reduced by the frequent intake of various antioxidants in the diet. Prospective studies are needed to confirm the relationship of dietary antioxidants to SAH risk in Japanese men and women.

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Intake of Flavonoids, Carotenoids, Vitamins C and E, and Risk of Stroke in Male Smokers

Cited by 192 publications

References 29 publications

Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women

Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women

The Occurrence, Fate and Biological Activities ofC-glycosyl Flavonoids in the Human Diet

Dietary antioxidant intake and risk of an aneurysmal rupture subarachnoid hemorrhage in Japan

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