Intake of jaboticaba peel attenuates oxidative stress in tissues and reduces circulating saturated lipids of rats with high-fat diet-induced obesity

Batista, Ângela Giovana; Lenquiste, Sabrina Alves; Cazarin, Cínthia Baú Betim; Silva, Juliana Kelly da; Luiz-Ferreira, Ânderson; Bogusz, Stanislau; Hantao, Leandro Wang; Souza, Renato Nunes de; Augusto, Fábio; Prado, Marcelo Alexandre; Maróstica, Mário Roberto

doi:10.1016/j.jff.2013.11.011

Cited by 91 publications

(72 citation statements)

References 39 publications

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“…Gallic acid values showed in FJP MeOH extract was 18% lower than found by Wu, Dastmalchi, Long, & Kennelly (2012), which evaluated the phenolic compounds by HPLC in the jaboticaba peel and jaboticaba juice. Nevertheless, in the present study results are in agreement with those demonstrate by Batista, Lenquiste, Cazarin, et al (2014). Ellagic acid content in FJP MeOH extract was similar to those reported by Abe, Lajolo, & Genovese (2012) -22.50 g Kg − 1 -and higher than the 348.08 mg 100 g − 1 obtained by Batista, Lenquiste, Cazarin, et al (2014) Anthocyanins are more soluble in water and methanol.…”

Section: Phenolic Compounds and Antioxidant Capacity In Fjp Extractssupporting

confidence: 93%

“…Nevertheless, in the present study results are in agreement with those demonstrate by Batista, Lenquiste, Cazarin, et al (2014). Ellagic acid content in FJP MeOH extract was similar to those reported by Abe, Lajolo, & Genovese (2012) -22.50 g Kg − 1 -and higher than the 348.08 mg 100 g − 1 obtained by Batista, Lenquiste, Cazarin, et al (2014) Anthocyanins are more soluble in water and methanol. However, it is known that heating may enhance the extraction of certain compounds, by breaking hydrogen bonds.…”

Section: Phenolic Compounds and Antioxidant Capacity In Fjp Extractssupporting

confidence: 93%

“…FRAP assay carried out by Alezandro, Dubé, Desjardins, Lajolo, & Genovese (2013a), Alezandro, Granato, & Genovese (2013b), and ABST by Leite-Legatti et al (2012) showed 68% and 51% lower values than those showed in this study. However, ORAC values obtained by Leite-Legatti, Batista, Dragano, et al (2012) and Batista, Lenquiste, & Cazarin, et al (2014) were higher when compared to the present results -25,514.24 μM TE g −1 and 519.11 μM TE g −1 , respectively.…”

Section: Phenolic Compounds and Antioxidant Capacity In Fjp Extractscontrasting

confidence: 91%

“…Total phenolic compounds, anthocyanins and flavonoids were higher in FJP MeOH extract than in FJP aqueous extract. Total phenolics and anthocyanins in the FJP MeOH extract were similar to those obtained by Alezandro, Dubé, Desjardins, Lajolo, & Genovese (2013a) and Alezandro, Granato, & Genovese (2013b), but lower than those obtained by Batista, Lenquiste, Cazarin, et al (2014).…”

Section: Phenolic Compounds and Antioxidant Capacity In Fjp Extractssupporting

confidence: 85%

“…2013a ;Alezandro, Granato, & Genovese, 2013b;Batista, Lenquiste, Cazarin, et al, 2014;Leite, Malta, Riccio, Eberlin, Pastore, & Marostica, 2011). In these studies, the jaboticaba peel showed elevated values of DPPH, FRAP, ABTS and ORAC assays, as well increases GSH and antioxidant enzymes in animal model.…”

Section: Introductionmentioning

confidence: 86%

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Jaboticaba peel and jaboticaba peel aqueous extract shows in vitro and in vivo antioxidant properties in obesity model

Lenquiste

Marineli

Moraes

et al. 2015

Food Research International

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This study evaluated the chemical composition of freeze-dried jaboticaba peel (FJP) and jaboticaba peel aqueous extract (JE) and their antioxidant capacity in vitro and in vivo in obesity model. Phenolic compounds, total anthocyanins, flavonoids and antioxidant capacity (DPPH, FRAP, ABTS and ORAC assays) in FJP methanolic extract and JE were measured. Specific phenolics (ellagic and gallic acids) and anthocyanin (cyanidin-3-O-glucoside) were measured by LC-DAD-ESI/MS. In the biological assay thirty-six Wistar rats were divided in six groups: AIN-93 M normal control diet; HFF (obese control) feed a high-fat and fructose diet; Prevention FJP (P. FJP) and Treatment FJP (T. FJP) feed HFF diet with 2% of FJP powder, for 12 and 6 weeks respectively; Prevention JE (P. JE) and Treatment JE (T. JE) were feed with HFF diet and the water was substituted by JE, for 12 and 6 weeks, respectively. FRAP, TBARS, GSH and antioxidant enzymes (GPx, GR, CAT and SOD) were determined in the plasma and liver. The limit of significance was set at P b 0.05. The FJP methanolic extract showed higher levels of total phenolics and anthocyanins, ellagic acid and DPPH, FRAP and ORAC assay, but JE showed higher levels of cyanidin-3-O-glucoside, gallic acid and ABTS assay. Antioxidant potential of the FJP and JE were confirmed by important markers in animals, such as TBARS and GSH levels and CAT activity, but not by FRAP assay, and SOD, GR and GPx enzymes. Thus, FJP and JE showed an important antioxidant effect in vitro and in vivo.

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Section: Phenolic Compounds and Antioxidant Capacity In Fjp Extractssupporting

confidence: 93%

Section: Phenolic Compounds and Antioxidant Capacity In Fjp Extractssupporting

confidence: 93%

Section: Phenolic Compounds and Antioxidant Capacity In Fjp Extractscontrasting

confidence: 91%

Section: Phenolic Compounds and Antioxidant Capacity In Fjp Extractssupporting

confidence: 85%

Section: Introductionmentioning

confidence: 86%

See 3 more Smart Citations

Jaboticaba peel and jaboticaba peel aqueous extract shows in vitro and in vivo antioxidant properties in obesity model

Lenquiste

Marineli

Moraes

et al. 2015

Food Research International

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Volatilome Study of Jabuticaba (Plinia cauliflora) Using a Hydrophilic Microporous Cartridge with Direct Immersion Solid Phase Microextraction and Gas Chromatography System With a Hybrid Quadrupole Time‐Of‐Flight Mass Spectrometry

de Oliveira,

Rodrigues,

Menezes

et al. 2024

J of Separation Science

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Jabuticaba (Plinia cauliflora) is a typical subtropical Brazilian fruit with unique organoleptic properties and a high nutritional value. This study shows a qualitative analysis of jabuticaba peels with volatile and semi‐volatile components harvested from Minas Gerais, Brazil. A new device, the hydrophilic microporous cartridge, was developed to extract jabuticaba peels' volatile/semi‐volatile components using a solid‐phase microextraction method by direct immersion. This cartridge protected the polymer phase fiber, preventing its breakage and impregnation of the material. The developed method is simple, using a few steps to prepare jabuticaba peel samples. The fiber selected for analysis was a divinylbenzene/carboxene/polydimethylsiloxane of 30/50 µm. A comprehensive two‐dimensional gas chromatography time‐of‐flight mass spectrometry system was used to analyze natural products in jabuticaba peels. The method was optimized by a factorial design and could detect 213 organic compounds. Of particular note is the detection of terpenes (33.27%), fatty acids (29.60%), and ethyl esters (9.23%), which are mainly responsible for the nutritional properties and odor of the fruit. This study presents an improved method for extracting volatile compounds, offering enhanced insights into the phytochemical composition, aroma, flavor, and bioactivity of jabuticaba.

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Jaboticaba berry peel intake prevents insulin‐resistance‐induced tau phosphorylation in mice

Batista

Soares

Mendonça

et al. 2017

Molecular Nutrition Food Res

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The hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as Alzheimer's disease. In this study, we used a high-fat diet to induce obesity and insulin resistance in adult Swiss mice and checked whether supplementation with Myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance, and prevent tau phosphorylation in the hippocampus. Furthermore, adipocytokines, inflammatory markers, and oxidative stress were assessed. Myrciaria jaboticaba peel has phenolic compounds (e.g., cyanidin, ellagic acid), dietary fiber and carotenoids, which contribute to great antioxidant capacity. Supplementation of the high-fat diet with 4% M. jaboticaba peel prevented fat weight gain and reduced peripheral insulin resistance. The treated group also showed lower tau phosphorylation in the hippocampus corroborating better learning/memory performance in the Morris water maze test. Maintenance of neuronal viability, lower levels of hippocampal inflammatory markers, and improved brain antioxidant defenses were also related to the consumption of M. jaboticaba peel. These findings contribute to a better understanding of how a high-fat diet supplemented with jaboticaba berry peel counteracts the impairment of cognitive functions caused by high-fat diet intake and diet-induced insulin resistance.

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Intake of jaboticaba peel attenuates oxidative stress in tissues and reduces circulating saturated lipids of rats with high-fat diet-induced obesity

Cited by 91 publications

References 39 publications

Jaboticaba peel and jaboticaba peel aqueous extract shows in vitro and in vivo antioxidant properties in obesity model

Jaboticaba peel and jaboticaba peel aqueous extract shows in vitro and in vivo antioxidant properties in obesity model

Volatilome Study of Jabuticaba (Plinia cauliflora) Using a Hydrophilic Microporous Cartridge with Direct Immersion Solid Phase Microextraction and Gas Chromatography System With a Hybrid Quadrupole Time‐Of‐Flight Mass Spectrometry

Jaboticaba berry peel intake prevents insulin‐resistance‐induced tau phosphorylation in mice

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