Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients

Ruano, Juan; López‐Miranda, José; Torre, Rafael de la; Delgado-Lista, Javier; Fernández, Javier; Caballero, Javier; Covas, María Isabel; Jiménez, Yolanda; Pérez-Martínez, Pablo; Marı́n, Carmen; Fuentes, Francisco; Pérez‐Jiménez, Francisco

doi:10.1093/ajcn/86.2.341

Cited by 89 publications

(59 citation statements)

References 47 publications

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“…This original investigation provides novel insight into the relationship between plant foods, specifically strawberry, and cardiovascular health, and supports research showing that a diet high in fruits and vegetables reduces disease risk [27][28][29]47) . We have now shown in both an acute 11,12) and chronic experimental paradigm (present study) that strawberry consumption influences adaptive and compensatory oxidative and inflammatory responses that likely underpin the observed effects on insulin metabolism 5,48) and fibrinolytic/thrombotic activity shown in the present study and by others 44) .…”

Section: Discussionsupporting

confidence: 63%

“…We assessed the effects of chronic strawberry feeding on these endpoints in the basal state (fasting measures) and when the body was in a state of physiological stress (postprandial/fed-state measures); with the latter suggested as a better indicator of disease risk [24][25][26] . An improved inflammatory and thrombotic status has been reported after chronic fruit and vegetable consumption as well as after chronic consumption of specific polyphenol-rich foods, including strawberry [27][28][29] . In contrast to these reports, we observed no statistically significant changes in fasting indices of inflammation, platelet function or fibrinolytic activity; although marginal effects (p 0.05-0.1) were evident for inflammatory indices.…”

Section: Discussionmentioning

confidence: 99%

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Attenuation of Meal-Induced Inflammatory and Thrombotic Responses in Overweight Men and Women After 6-Week Daily Strawberry (Fragaria) Intake

Ellis

Edirisinghe

Kappagoda

et al. 2011

JAT

102

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Aim: A pro-thrombotic, pro-inflammatory diet can play a causative role in atherosclerotic-cardiovascular diseases. Dietary intervention studies provide insight into their pathophysiological manifestations and opportunities for prevention and management. We previously showed in an acute-meal setting that a beverage containing polyphenolic-and antioxidant-rich strawberry (Fragaria) vs placebo attenuated postprandial (fed-state) increases in biomarkers of oxidative and inflammatory stress, and insulin concentrations, induced by a high carbohydrate/fat (HCF) meal. In the present study, we aimed to extend our findings and investigate hypotheses related to the effects of chronic/6-week (wk) strawberry consumption on HCF meal-induced increases in glucose, insulin, and indicators of inflammation and hemostasis. Methods: In a crossover design, 14 women and 10 men (mean age, BMI: 50.9 15 years, 29.2 2.3 kg/m 2 , respectively), were randomized to a 6-wk strawberry or placebo beverage followed by an HCF meal with assessments for 6-hours (h) postprandially. Results: HCF meal responses after 6-wk strawberry beverage showed significantly attenuated postprandial PAI-1 concentrations compared to the placebo (p 0.002); the difference was most notable at 6 h. The IL-1 response was attenuated with strawberry compared to the placebo (p 0.05). IL-6 attenuation was apparent but non-significant; IL-6 rose significantly from baseline to 6 h after the HCF meal following a placebo (p ≤ 0.01), although it remained relatively flat following the strawberry beverage from fasting to 6 h. No significant treatment-related differences were apparent for platelet aggregation, hsCRP, TNF-, insulin, or glucose. Conclusion: These data are the first to suggest that regular consumption of strawberry, a polyphenolic-and antioxidant-rich fruit, may provide protection from HCF meal-induced increases in fibrinolytic and inflammatory factors in at-risk men and women.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Attenuation of Meal-Induced Inflammatory and Thrombotic Responses in Overweight Men and Women After 6-Week Daily Strawberry (Fragaria) Intake

Ellis

Edirisinghe

Kappagoda

et al. 2011

JAT

102

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“…4 Moreover, HT is involved in the inhibition of lipid and protein oxidation in human plasma, 5 having anti-inammatory 6 and antiplatelet aggregation properties. 7 Additionally, there is evidence that olive oil phenolic compounds decrease plasma glucose levels in rats. 8,9 HT can be efficiently recovered from olive by-products, which has prompted the study of the biological and health effects of HT from alperujo 8,10 or olive leaves.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats

et al. 2014

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Hydroxytyrosol (HT), a virgin olive oil phenolic phytochemical with proven health benefits, has been used to generate new lipophilic antioxidants to preserve fats and oils against autoxidation. The aim of this work is to comparatively evaluate the physiological effects of HT and its lipophilic derivatives, hydroxytyrosyl acetate (HT-Ac) and ethyl hydroxytyrosyl ether (HT-Et), in high-cholesterol fed animals. Male Wistar rats (n ¼ 8)were fed a standard diet (C group), a cholesterol-rich diet (Chol group) or a cholesterol-rich diet supplemented with phenolic compounds (HT group, HT-Ac group and HT-Et group) for 8 weeks. Body and tissue weights, the lipid profile, redox status, and biochemical, hormonal, and inflammatory biomarkers were evaluated. Plasma levels of total cholesterol, LDL cholesterol, glucose, insulin and leptin, as well as malondialdehyde in serum increased in Chol compared to C (p < 0.05). Rats fed the test diets had improved glucose, insulin, leptin and MDA levels and antioxidant capacity status, with HT-Ac being the most effective compound. The studied phenolic compounds also modulated TNF-a and IL-1b plasma levels compared to Chol. HT-Ac and HT-Et improved adipose tissue distribution and adipokine production, decreasing MCP-1 and IL-1b levels. Our results confirm the metabolic effects of HT, which are maintained and even improved by hydrophobic derivatives, particularly HT-Ac.

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“…In five of the human intervention studies (Estevez-Gonzalez et al, 2010;Haban et al, 2004;Perona et al, 2011;Ruano et al, 2007;Violante et al, 2009), as well as in one animal study (MangasCruz et al, 2001), the content of hydroxytyrosol or its derivatives (e.g. oleuropein complex) in the olive oils administered in the studies was not reported.…”

Section: Scientific Substantiation Of the Claimed Effect (Id 1639)mentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to polyphenols in olive and maintenance of normal blood HDL cholesterol concentrations (ID 1639, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

Products¹

2012

EFSA Journal

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Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to provide a scientific opinion on a health claim pursuant to Article 13 of Regulation (EC) No 1924 in the framework of further assessment related to polyphenols in olive and maintenance of normal blood HDL-cholesterol concentrations. The food constituent, polyphenols in olive (olive fruit, olive mill waste waters or olive oil, Olea europaea L. extract and leaf) standardised by their content of hydroxytyrosol and its derivatives (e.g. oleuropein complex), that is the subject of the health claim is sufficiently characterised. The claimed effect, maintenance of normal blood HDL-cholesterol concentrations, which is eligible for further assessment, is a beneficial physiological effect. The proposed target population is the general population. No evidence from which conclusions could be drawn for the scientific substantiation of the claim, in addition to the Panel's earlier opinion, was provided. The Panel considers that no data were submitted which would require a reconsideration of the conclusions expressed in its previous opinion, in which it concluded that the evidence provided was insufficient to establish a cause and effect relationship between the consumption of olive oil polyphenols (standardised by the content of hydroxytyrosol and its derivatives) and maintenance of normal blood HDL cholesterol concentrations. SUMMARYFollowing a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924. The Commission has agreed with EU Member States that a certain number of Article 13 health claims would be eligible for further assessment by EFSA in order to be able to take a final decision on whether or not to include these claims in the list of permitted health claims. This opinion addresses the scientific substantiation of a health claim in relation to polyphenols in olive and maintenance of normal blood HDL-cholesterol concentrations. The assessment is based on the information provided by the Member States in the consolidated list of Article 13 health claims, references that EFSA has received from Member States or directly from stakeholders and the additional information provided by the competent Authority of Germany for further assessment of this claim.The food constituent that is the subject of the health claim is polyphenols in olive. The Panel considers that polyphenols in olive (olive fruit, olive mill waste waters or olive oil, Olea europaea L. extract and leaf) standardised by their content of hydroxytyrosol and its derivatives (e.g. oleuropein complex) are sufficiently characterised.The claimed effect, which is eligible for further assessment, relates to the maintenance of normal blood HDL-cholesterol concentrations. The proposed target population is the general population. The Panel considers that maintenance of normal bloo...

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Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients

Cited by 89 publications

References 47 publications

Attenuation of Meal-Induced Inflammatory and Thrombotic Responses in Overweight Men and Women After 6-Week Daily Strawberry (Fragaria) Intake

Attenuation of Meal-Induced Inflammatory and Thrombotic Responses in Overweight Men and Women After 6-Week Daily Strawberry (Fragaria) Intake

Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats

Scientific Opinion on the substantiation of a health claim related to polyphenols in olive and maintenance of normal blood HDL cholesterol concentrations (ID 1639, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

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