Intake of purple sweet potato beverage affects on serum hepatic biomarker levels of healthy adult men with borderline hepatitis

Abstract

Objective: To examine the effect of purple sweet potato (PSP) beverage rich in acylated anthocyanins on serum hepatic biomarkers in healthy Japanese men. Design: A randomized, double-blind, placebo-controlled, parallel study. Setting: Kumamoto in Japan. Subjects: Healthy adult men (30-60 years) with borderline hepatitis who had one or more of serum g-glutamyl transferase (GGT), aspertate aminotransferase (AST) and alanine aminotransferase (ALT) levels over normal ranges, and who were negative for hepatitis virus were openly recruited by an advertisement. Of the 48 persons enrolled, 38 (mean age 43.0 years (30-54 years)) completed the study. Methods: The subjects were randomly assigned to the PSP group and the placebo group. During the 8-week intervention, the subjects in the PSP group consumed two bottles of the PSP beverage with acylated anthocyanins (200.3 mg anthocyanins per 125 ml per bottle) per day, and the subjects in the placebo group, two bottles of a placebo beverage (1.7 mg anthocyanins per 125 ml per bottle). All of the data measured were analyzed by two-way repeated measures analysis of variance (ANOVA) with groups and times. The data of the hepatic markers were analyzed using the Dunnett multiple comparison among the time points and t-test between groups at the same time point. Two-sided Po0.05 were defined as the level of significance. Results: Serum GGT, AST and ALT levels showed interactions (Po0.05) between the beverage groups and time; the others were not affected. The PSP beverage group showed lower hepatic marker levels than the placebo group during the ingestion period, particularly the GGT level (À14.1 IU/l, 95% Confidence intervel (CI) À25.4 to À2.7, P ¼ 0.017 at 2 weeks; À16.8 IU/l, 95% CI À36.2 to 2.5, P ¼ 0.081 at 4 weeks; À26.7 IU/l, 95% CI À47.6 to À5.7, P ¼ 0.014 at 6 weeks and À27.9 IU/l, 95% CI À49.9 to À5.9; P ¼ 0.014 at 8 weeks). No correlation between alcohol consumption and each hepatic biomarker level before and after the ingestion was observed. Conclusion: The intake of the PSP beverage significantly decreased the serum levels of hepatic biomarkers, particularly the GGT level, in healthy men with borderline hepatitis.

Purple Sweet Potato Pigments Scavenge ROS, Reduce p53 and Modulate Bcl-2/Bax to Inhibit Irradiation-induced Apoptosis in Murine Thymocytes

“…Most of the PSP pigments related studies focused on the neuroprotection [11, 13,16,17], hepatoprotection [12,18,19], immunomodulation [20][21][22], and antiatherosclerosis [23,24]. There has been limited information about the radioprotective effects of PSP pigments.…”

Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

“…It has been reported that ACNs decrease hepatic lipid accumulation and may counteract oxidative stress and hepatic inflammation in animal studies, but their benefits in patients with NAFLD has not yet been well elucidated [44] . There is only one study evaluating the effects of ACN on NAFLD patients; Suda et al [45] have reported that supplementation with 400 mg of acylated ACNs could reduce levels of liver enzymes, in particular gamma-glutamyl transferases in patients with NAFLD. This clinical trial had many limitations; liver damage was not directly assessed, fatty liver was not confirmed by direct imaging, and the effect of acylated ACNs was not compared to that of a control food or to the lack of intervention [45] .…”

“…There is only one study evaluating the effects of ACN on NAFLD patients; Suda et al [45] have reported that supplementation with 400 mg of acylated ACNs could reduce levels of liver enzymes, in particular gamma-glutamyl transferases in patients with NAFLD. This clinical trial had many limitations; liver damage was not directly assessed, fatty liver was not confirmed by direct imaging, and the effect of acylated ACNs was not compared to that of a control food or to the lack of intervention [45] . More research studies are therefore required to evaluate the effects of ACNs supplementation on NAFLD features.…”

Dietary Anthocyanins: Impact on Colorectal Cancer and Mechanisms of Action

“…There are several studies, in normal cells and tissues, in which it was demonstrated that anthocyanins, probably involving some protein kinases, modulate the activity of some GSHdependent enzymes, thus ameliorating the antioxidant response (Hou et al, 2010;Suda et al, 2008;Veigas et al, 2008). GSSG formed intracellularly is continuously reduced to GSH by the activity of GR.…”