Due to the surge in the volume of data generated and rapid advancement in Artificial Intelligence (AI) techniques like machine learning and deep learning, the existing traditional computing models have become inadequate to process an enormous volume of data and the complex application logic for extracting intrinsic information. Computing accelerators such as Graphics processing units (GPUs) have become de facto SIMD computing system for many big data and machine learning applications. On the other hand, the traditional computing model has gradually switched from conventional ownership-based computing to subscription-based cloud computing model. However, the lack of programming models and frameworks to develop cloud-native applications in a seamless manner to utilize both CPU and GPU resources in the cloud has become a bottleneck for rapid application development.To support this application demand for simultaneous heterogeneous resource usage, programming models and new frameworks are needed to manage the underlying resources effectively. Aneka is emerged as a popular PaaS computing model for the development of Cloud applications using multiple programming models like Thread, Task, and MapReduce in a single container .NET platform. Since, Aneka addresses MIMD application development 2 that uses CPU based resources and GPU programming like CUDA is designed for SIMD application development, here, the chapter discusses GPU PaaS computing model for Aneka Clouds for rapid cloud application development for .NET platforms. The popular opensource GPU libraries are utilized and integrated it into the existing Aneka task programming model.The scheduling policies are extended that automatically identify GPU machines and schedule respective tasks accordingly. A case study on image processing is discussed to demonstrate the system, which has been built using PaaS Aneka SDKs and CUDA library.