Integral analyses of survival‑related long non‑coding RNA MIR210HG and its prognostic role in colon cancer

Ruan, Zhaohui; Xu, Zixuan; Li, Zhaozhi; Lv, Yanni

doi:10.3892/ol.2019.10435

Cited by 20 publications

(20 citation statements)

References 36 publications

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“…In this study, we identified a novel function of MIR210HG in regulating the Warburg effect. In line with our result, RUAN et al showed that higher MIR210HG expression was associated with shorter overall survival in colon cancer and MIR210HG may play a role in the modulation of energy metabolism, especially glucose metabolism ( 48 ). Polysome profiling of HIF-1α mRNA showed reduced translation of HIF-1α in MIR210HG knockdown cells, suggesting the regulatory role if MIR210HG in HIF-1a translation process.…”

Section: Discussionsupporting

confidence: 92%

Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer

Wei

et al. 2020

Front. Oncol.

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BackgroundHypoxia is an important environmental factor and has been correlated with tumor progression, treatment resistance and poor prognosis in many solid tumors, including triple-negative breast cancer (TNBC). Emerging evidence suggests that long noncoding RNA (lncRNA) functions as a critical regulator in tumor biology. However, little is known about the link between hypoxia and lncRNAs in TNBC.MethodsTNBC molecular profiles from The Cancer Genome Atlas (TCGA) were leveraged to identify hypoxia-related molecular alterations. Loss-of-function studies were performed to determine the regulatory role of MIR210HG in tumor glycolysis. The potential functions and mechanisms of hypoxia-MIR210HG axis were explored using qPCR, Western blotting, luciferase reporter assay, and polysome profiling.ResultsWe found that MIR210HG is a hypoxia-induced lncRNA in TNBC. Loss-of-function studies revealed that MIR210HG promoted the Warburg effect as demonstrated by glucose uptake, lactate production and expression of glycolytic components. Mechanistically, MIR210HG potentiated the metabolic transcription factor hypoxia-inducible factor 1α (HIF-1α) translation via directly binding to the 5’-UTR of HIF-1α mRNA, leading to increased HIF-1a protein level, thereby upregulating expression of glycolytic enzymes. MIR210HG knockdown in TNBC cells reduced their glycolytic metabolism and abolished their tumorigenic potential, indicating the glycolysis-dependent oncogenic activity of MIR210HG in TNBC. Moreover, MIR210HG was highly expressed in breast cancer and predicted poor clinical outcome.ConclusionOur results decipher a positive feedback loop between hypoxia and MIR210HG that drive the Warburg effect and suggest that MIR210HG may be a good prognostic marker and therapeutic target for TNBC patients.

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Section: Discussionsupporting

confidence: 92%

Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer

Wei

et al. 2020

Front. Oncol.

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“…MIR210HG was also demonstrated to facilitate progress of lung cancer [21], glioma [22], and hepatocellular carcinoma [23]. Moreover, two articles using bioinformatics methods identi ed MIR210HG was associated with poor OS of patients with colon cancer [24,25], which was in accordance with the results of our study. Our results imply potential functions of the ve immune-related lncRNA signature in the development of colon cancer, suggesting them as important biomarkers and therapeutic targets.…”

Section: Discussionsupporting

confidence: 91%

A prognostic five immune-related long noncoding RNA signature for patients with colon cancer

Zhao

Wang

Kang

et al. 2020

Preprint

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Background: Our study aimed to identify immune related long non-coding RNAs (LncRNAs) to serve as potential prognostic indicators and immune therapeutic targets in patients with colon cancer.Methods: The Cancer Genome Atlas (TCGA) and Molecular Signatures Databases (MSigDB) database were used to identify immune related lncRNAs in patients with colon cancer. The least absolute shrinkage and selection operator (LASSO) analysis, and multivariate Cox proportional hazards regression analysis were employed to screen prognostic lncRNAs and construct immune-related multi-lncRNA signature. We used time-dependent receiver operating characteristic curve to assess the performance of this signature in colon cancer by calculating the area under the curve (AUC). Univariate and multivariate Cox regression analysis were performed to verify the independence of the prognostic value of this signature in colon cancer.Results: Five immune related lncRNAs (AC025575.2, AL161729.4, ELFN1-AS1, LINC00513, MIR210HG) were found to be significantly associated with overall survival (OS) of patients with colon cancer. Then, we developed a five immune-related lncRNA signature. According to this signature, patients were ranked into a high risk group (n = 208) and a low risk group (n = 209). Kaplan-Meier curve and log-rank method showed that patients in high risk group had worse OS than patients in low risk group (P = 5.5644e-05). AUC for predicting 3 year survival and 5 year survival was 0.776 and 0.762 respectively, which indicated good performance of this signature. Finally, this five immune-related lncRNA signature was demonstrated to be independently associated with prognosis of patients with colon cancer.Conclusion: We developed a five immune-related lncRNA signature as a prognostic biomarker for patients with colon cancer.

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“…Of these six lncRNAs, MIR210HG is a common lncRNA that is highly expressed in a variety of tumors. In the 373 colon cancer patients, the 5-year survival rate of patients in the MIR210HG high expression group was lower than the 5-year survival rate of patients in the MIR210HG low expression group ( Ruan et al, 2019 ). In invasive breast cancer, MIR210HG is elevated in cancer tissues, and high MIR210HG expression is positively associated with a poor prognosis ( Li et al, 2019 ).…”

Section: Discussionmentioning

confidence: 84%

Six-lncRNA Immune Prognostic Signature for Cervical Cancer

Chen

Huang

et al. 2020

Front. Genet.

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Background This study searched for immune-related long noncoding RNAs (lncRNAs) to predict the prognosis of patients with cervical cancer. Method We obtained immunologically relevant lncRNA expression profiles and clinical follow-up data from cervical cancer patients from The Cancer Genome Atlas database and the Molecular Signatures Database. Cervical cancer patients were randomly divided into a training group, testing group and combined group. The immune prognostic signature was constructed by Least Absolute Shrinkage and Selection Operator Cox regression, prognosis was analyzed by Kaplan–Meier curves between different groups, and the accuracy of the prognostic model was assessed by receiver operating characteristic-area under the curve (ROC-AUC) analysis. Results A six-lncRNA immune prognostic signature (LIPS) was constructed to predict the prognosis of cervical cancer. The six lncRNAs are as follows: AC009065.8, LINC01871, MIR210HG, GEMIN7-AS1, GAS5-AS1, and DLEU1. A ROC-AUC analysis indicated that the model could predict the prognosis of cervical cancer patients in different subgroups. A Kaplan–Meier analysis showed that patients with high risk scores had a poor prognosis; these results were equally meaningful in the subgroup analyses. Risk scores differed depending on the clinical pathology and tumor grade and were independent risk factors for cervical cancer prognosis. Gene set enrichment analysis revealed an association between the LIPS and the immune response, Wnt signaling pathway, and TGF beta signaling pathway. Conclusion Our study shows that the six-LIPS can predict the prognosis of cervical cancer and contribute to decisions regarding the immunotherapeutic strategy.

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Integral analyses of survival‑related long non‑coding RNA MIR210HG and its prognostic role in colon cancer

Cited by 20 publications

References 36 publications

Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer

Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer

A prognostic five immune-related long noncoding RNA signature for patients with colon cancer

Six-lncRNA Immune Prognostic Signature for Cervical Cancer

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