Relevance. Today, inflammatory periodontal diseases are one of the most common pathologies seen at dental appointments. During the treatment of these diseases, the main goal of the therapy is to reduce the intensity of inflammatory manifestations.Materials and methods. The article presents the results of the application of the original method of carboxytherapy to reduce the inflammatory component at the initial phase of the treatment of inflammatory periodontal diseases.The technique suggests the injection of 0.5–1.0 ml of medical carbon dioxide into the vestibular mucobuccal fold and the dental papillae region with a special injector. The study was conducted at the department of prosthodontics of Samara State Medical University. The study divided the patients into two groups. The control group underwent professional oral hygiene, and the main-group patients had an additional carboxytherapy treatment developed by the authors. The study evaluated the effectiveness of the treatment using the OHI-S, PMA, and Muhllemann indices and the restoration of blood filling using the periodontal bloo d flow assessment method.Results. After the treatment, the main group showed a statistically significant decrease in the assessed indices and blood circulation restoration in the periodontium, which indicates a significant effect of the method used. Allergic and toxic effects on the mucous membrane did not manifest in the carboxytherapy group during the observation period. Patients did not complain about pain and discomfort.Conclusion. So, based on the conducted studies, we can conclude that the method of carboxytherapy is highly effective as one of the elements of the c omplex treatment of periodontal diseases.