“…The concept of integral dose (or energy imparted) was originally introduced in radiotherapy in ;he hope that good correlation with patient response to radiation treatment could be obtained. Estimation of the energy imparted has usually been based either upon an integration of measured depth-dose data (usually extrapolated to infinite field size) or by calculation of the incident energy fluence together with an estimate of the fraction of energy absorbed in the patient (Happey 1940, 1941, Mayneord 1940, Smithers 1942, Mayneord and Clarkson 1944, Meredith and Neary 1944, Ellis 1945, Loeffler 1956, Bewley er a1 1959, Scarpa 1960, Carlsson 1963.…”