Abstract-This paper presents an efficient hybrid simulation technique for analysis of the electromagnetic field interactions between multi-transmitters and receivers located within a closed environment. The Method of Moments/circuit method is first used for modeling of the transceivers and their nearby surrounding to obtain the equivalent sources/receivers. Then, an approach that combines the asymptotic method and the ray tracing technique is deployed to calculate the long-distance coupling between a pair of transmitter and receiver. The acceleration algorithms for ray tracing have been developed to deal with more complex scenarios. The seamless combination between the circuit, numerical, and asymptotic approaches is the key to get accurate simulation results. Several numerical examples and experimental results are presented to demonstrate the efficiency of the proposed technique.