Motion sickness (MS) has long been a common complaint in road transportation. However, in the era of driving automation, MS has become an increasingly significant issue. The future intelligent vehicle is envisioned as a mobile space for work or entertainment, but unfortunately passengers’ engagement in non-driving tasks may exacerbate MS. Finding effective MS countermeasures is crucial to ensure a pleasant passenger experience. Nevertheless, due to the complex mechanism of MS, there are numerous challenges in mitigating it, hindering the development of practical countermeasures. To address this, we first review two prevalent theories explaining the mechanism of MS. Subsequently, this paper provides a summary of current subjective and objective approaches for quantifying motion sickness levels. Then, it surveys existing methods for alleviating MS, including passenger adjustment, intelligent vehicle solutions, and motion cues of various modalities. Furthermore, we outline the limitations and remaining challenges of current research and highlight novel opportunities in the context of intelligent vehicles. Finally, we propose an integrated framework for alleviating MS. The findings of this review will enhance our understanding of carsickness and offer valuable insights for future research and practice in MS mitigation within modern vehicles.