Integrated aquaculture contributes to the transfer of mcr-1 between animals and humans via the aquaculture supply chain

Shen, Yingbo; Lv, Ziquan; Lü, Yang; Liu, Dejun; Ou, Yanran; Xu, Chunyan; Liu, Weiwen; Yuan, Dongmei; Hao, Yuxin; He, Jiakang; Li, Xing; Zhou, Yuqing; Walsh, Timothy R.; Shen, Jianzhong; Xia, Junjie; Ke, Yuebin; Wang, Yang

doi:10.1016/j.envint.2019.03.056

Cited by 59 publications

(63 citation statements)

References 33 publications

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“…Whole-genome analyses confirmed the transmission of mcr-1-carrying E. coli between animals not only in the integrated farm but also in the slaughterhouse, and provided evidence that mcr-1 could be transferable between bacteria from animals and humans via this supply chain (Fig. 3) (Shen et al, 2019).…”

Section: Transmission Between Humans and Animals Via The Food Productmentioning

confidence: 82%

“…More recently, Shen et al identified strong correlations between a high prevalence of mcr-1-positive bacteria in humans and anthropogenic factors, including consumption of animal-and aquaculturederived food products (Shen et al, 2018c). Based on these findings, a further study investigated a freshwater aquaculture supply chain, including a duck-fish integrated farm, a slaughterhouse, and a market, and detected a high prevalence of mcr-1 (average of 22.4%) among samples from each steps in the chain (Shen et al, 2019). Whole-genome analyses confirmed the transmission of mcr-1-carrying E. coli between animals not only in the integrated farm but also in the slaughterhouse, and provided evidence that mcr-1 could be transferable between bacteria from animals and humans via this supply chain (Fig.…”

Section: Transmission Between Humans and Animals Via The Food Productmentioning

confidence: 99%

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Farm animals and aquaculture: significant reservoirs of mobile colistin resistance genes

Shen

Zhang

Schwarz

et al. 2020

Environmental Microbiology

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Summary Colistin resistance has attracted substantial attention after colistin was considered as a last‐resort drug for the treatment of infections caused by carbapenem‐resistant and/or multidrug‐resistant (MDR) Gram‐negative bacteria in clinical settings. However, with the discovery of highly mobile colistin resistance (mcr) genes, colistin resistance has become an increasingly urgent issue worldwide. Despite many reviews, which summarized the prevalence, mechanisms, and structures of these genes in bacteria of human and animal origin, studies on the prevalence of mobile colistin resistance genes in aquaculture and their transmission between animals and humans remain scarce. Herein, we review recent reports on the prevalence of colistin resistance genes in animals, especially wildlife and aquaculture, and their possibility of transmission to humans via the food chain. This review also gives some insights into the routine surveillance, changing policy and replacement of polymyxins by polymyxin derivatives, molecular inhibitors, and traditional Chinese medicine to tackle colistin resistance.

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Section: Transmission Between Humans and Animals Via The Food Productmentioning

confidence: 82%

Section: Transmission Between Humans and Animals Via The Food Productmentioning

confidence: 99%

Farm animals and aquaculture: significant reservoirs of mobile colistin resistance genes

Shen

Zhang

Schwarz

et al. 2020

Environmental Microbiology

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“…In a study conducted on integrated fish-duck farming, it was suggested that E. coli harboring the mcr-1 can spread from aquatic animals to affect the supply chain and humans [ 24 ]. Therefore, the detection of mcr-1.1 in fish poses a significant public health concern, because resistance can be potentially transmitted to pathogens that affect humans and other animals [ 23 , 24 ]. Additionally, international trade with farmed fish can act as a route for the dissemination of mcr between countries [ 18 , 68 ].…”

Section: Resultsmentioning

confidence: 99%

“…It was proposed that aquatic systems are a significant reservoir for colistin-resistant genes and can transmit them directly and indirectly to humans [ 22 ]. Furthermore, seven and two mcr-1 -positive E. coli were recovered from grass carp fish farms and fish in integrated fishery operations in Guangzhou in Southern China [ 23 , 24 ]. In Vietnam, mcr-1 was detected in one extended-spectrum beta-lactamase (ESBL)-producing E. coli isolated from striped catfish grown in ponds [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…A recent study from Spain reported mcr-1 in Salmonella enterica serovar Rissen isolated from mussels [ 27 ]. However, beyond these few studies on farmed fish in China and Vietnam and on mussels in Spain [ 23 , 24 , 25 , 26 , 27 ], data on the occurrence of mcr in aquaculture have been limited. Therefore, it is important to investigate colistin resistance and mcr in aquaculture globally, especially in developing countries with limited infrastructure and documented challenges in pollution.…”

Section: Introductionmentioning

confidence: 99%

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The Mobile Colistin Resistance Gene, mcr-1.1, Is Carried on IncX4 Plasmids in Multidrug Resistant E. coli Isolated from Rainbow Trout Aquaculture

et al. 2020

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Colistin, a last resort antibiotic, is important for controlling infections with carbapenem-resistant Enterobacteriaceae. The recent emergence of mobile-colistin-resistance (mcr) genes has threatened the effectiveness of colistin. Aquaculture is hypothesized to be a major contributor to the evolution and dissemination of mcr. However, data on mcr in aquaculture are limited. Here, the occurrence of mcr-1 was assessed in Rainbow Trout in Lebanon, a country with developing antimicrobial stewardship and an established use of colistin for medical and farming purposes. mcr-1 was detected in 5 Escherichia coli isolated from fish guts. The isolates were classified as multidrug-resistant and their colistin minimum inhibitory concentration ranged between 16 and 32 μg/mL. Whole genome sequencing analysis showed that mcr-1 was carried on transmissible IncX4 plasmids and that the isolates harbored more than 14 antibiotic resistance genes. The isolates belonged to ST48 and ST101, which have been associated with mcr and can occur in humans and fish. The mcr-1-positive E. coli persisted in 6-day biofilms, but there was a potential fitness cost. Given the status of infrastructure in Lebanon, there is a high potential for the dissemination of mcr via aquatic environments. Urgent actions are needed to control mcr and to enhance antimicrobial stewardship in Lebanon.

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Colistin Resistance in Aquaculture Environment: An Emerging Challenge

Dwivedi

Awasthi

2023

Macromolecular Symposia

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The emergence of colistin resistance is one of the most serious future issues since it is a last‐resort antibiotic used to treat infections caused by multidrug‐resistant (MDR) gram‐negative bacteria, particularly those resistant to carbapenems. The aquatic environment acts as a reservoir for the emergence and spread of colistin resistant pathogens. The emergence and transmission of a plasmid mediated mcr gene is one of the most important mechanism of colistin resistance in gram negative bacteria. Several mcr variants have been identified in zoonotic pathogens of aquatic origin that may easily transmit this gene to human pathogens. Currently, very few studies have been conducted to test colistin susceptibility in aquaculture associated bacteria. This may be attributed to a limited technical resource for screening colistin‐resistant microorganisms. As a result, to reduce the emergence and spread of colistin resistance in human and animal health, as well as in the environment, the One Health strategy and laboratory methodologies must be expanded.

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Integrated aquaculture contributes to the transfer of mcr-1 between animals and humans via the aquaculture supply chain

Cited by 59 publications

References 33 publications

Farm animals and aquaculture: significant reservoirs of mobile colistin resistance genes

Farm animals and aquaculture: significant reservoirs of mobile colistin resistance genes

The Mobile Colistin Resistance Gene, mcr-1.1, Is Carried on IncX4 Plasmids in Multidrug Resistant E. coli Isolated from Rainbow Trout Aquaculture

Colistin Resistance in Aquaculture Environment: An Emerging Challenge

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