Integrated bioinformatics analysis of the association between apolipoprotein E expression and patient prognosis in papillary thyroid carcinoma

Jiang, Qunguang; Feng, Wenqian; Cai, Xiong; Lv, Yunxia

doi:10.3892/ol.2020.11316

Cited by 6 publications

(7 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ApoE is related to overall survival and disease-free survival significantly. Low expression of ApoE is also associated with the advanced TNM stage, which indicates that ApoE can act as a biomarker to predict PTC progression and prognosis (Jiang et al, 2020). In addition, liver X receptor β (LXRβ) is overexpressed in PTC and induce the expression of its target genes including APOC1, APOC2 and APOE, which may activate lipid metabolism and protein synthesis, thus facilitating cancer cell proliferation.…”

Section: Thyroid Cancermentioning

confidence: 99%

Apolipoproteins: New players in cancers

Chen²,

Ma³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Apolipoproteins (APOs), the primary protein moiety of lipoproteins, are known for their crucial role in lipid traffic and metabolism. Despite extensive exploration of APOs in cardiovascular diseases, their roles in cancers did not attract enough attention. Recently, research focusing on the roles of APOs in cancers has flourished. Multiple studies demonstrate the interaction of APOs with classical pathways of tumorigenesis. Besides, the dysregulation of APOs may indicate cancer occurrence and progression, thus serving as potential biomarkers for cancer patients. Herein, we summarize the mechanisms of APOs involved in the development of various cancers, their applications as cancer biomarkers and their genetic polymorphism associated with cancer risk. Additionally, we also discuss the potential anti-cancer therapies by virtue of APOs. The comprehensive review of APOs in cancers may advance the understanding of the roles of APOs in cancers and their potential mechanisms. We hope that it will provide novel clues and new therapeutic strategies for cancers.

show abstract

Section: Thyroid Cancermentioning

confidence: 99%

Apolipoproteins: New players in cancers

Chen²,

Ma³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…In addition to this finding, data showed that decreased APOE expression in PTC is associated with a statically significant decreased overall survival and found no correlation with disease-free survival [188]. This finding conflicts with other papers that found a statistically significant correlation between APOE and disease-free survival in PTC patients [189,192,194]. Further investigations concluded that mRNA levels of APOE were positively associated with the TNM staging of PTC [189,194].…”

Section: Apolipoproteins In Thyroid Cancermentioning

confidence: 56%

The Role of Apolipoproteins in the Commonest Cancers: A Review

Darwish,

Al-Hail,

Mohamed

et al. 2023

Cancers

View full text Add to dashboard Cite

Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the onset of a variety of human cancers; however, the role of certain APOs in cancer development remains unknown. Based on recent work, we hypothesize that APOs might be involved in the onset of cancer, with a focus on the most common cancers, including breast, lung, gynecological, colorectal, thyroid, gastric, pancreatic, hepatic, and prostate cancers. This review will focus on the evidence supporting this hypothesis, the mechanisms linking APOs to the onset of cancer, and the potential clinical relevance of its various inhibitors.

show abstract

“…A study utilizing the TCGA and GEO databases for analysis of neoplastic thyroid tissue identified 134 differentially expressed genes (DEGs) with upregulation and 106 DEGs with downregulation. The analysis revealed that these DEGs were enriched in thyroid hormone synthesis and metabolic pathways (11). Our findings on differentially expressed genes in thyroid cancer are consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Identification of Metabolic Pathways Altered in Thyroid Cancer Progression and Metastasis

de Oliveira Andrade,

Matos de Oliveira,

Matos de Oliveira

et al. 2023

Preprint

View full text Add to dashboard Cite

Introduction: Thyroid cancer is a common endocrine malignancy with a rising incidence. However, to improve patient outcomes, it is essential to understand the molecular mechanisms driving its progression and metastasis, and the metabolomics can unveil alterations in metabolic pathways that contribute to thyroid cancer. Objective: To identify the metabolic pathways altered in thyroid cancer progression and metastasis. Methods: Multiple bioinformatics tools were employed in the research. Gene expression data was obtained from the Gene Expression Omnibus and The Cancer Genome Atlas. Functional assessment of the expressed genes in thyroid cancer was performed using gene set enrichment analysis. The Kyoto Encyclopedia of Genes and Genomes database was utilized to identify the metabolic pathway involved in thyroid cancer progression and metastasis. A computational algorithm was developed to estimate the activity levels of the identified metabolic pathways and construct a signaling pathway. Results: The altered metabolic pathways in thyroid cancer progression and metastasis were identified based on the following algorithm: activation of growth factor signaling, activation of multiple signaling pathways, regulation by transcription factors, dysregulation of downstream signaling cascades, changes in cellular metabolism, tumor progression, invasion and metastasis, and feedback regulation. Conclusion: By applying a comprehensive algorithm, we were able to uncover key molecular events driving the aggressive behavior of thyroid cancer. These findings provide insights into the underlying mechanisms of thyroid cancer progression and metastasis. Keywords: Thyroid cancer, metabolic pathways, metastasis.

show abstract

Integrated bioinformatics analysis of the association between apolipoprotein E expression and patient prognosis in papillary thyroid carcinoma

Cited by 6 publications

References 58 publications

Apolipoproteins: New players in cancers

Apolipoproteins: New players in cancers

The Role of Apolipoproteins in the Commonest Cancers: A Review

Identification of Metabolic Pathways Altered in Thyroid Cancer Progression and Metastasis

Contact Info

Product

Resources

About