Integrated Carbon Nanostructures for Detection of Neurotransmitters

Sainio, Sami; Palomäki, Tommi; Tujunen, Noora; Protopopova, Vera; Koehne, Jessica E.; Kordás, Krisztián; Koskinen, Jari; Meyyappan, M.; Laurila, Tomi

doi:10.1007/s12035-015-9233-z

Cited by 41 publications

(51 citation statements)

References 21 publications

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“…Microelectrodes of tungsten (W) wires with uniform layers SWCNT demonstrated outstanding performance and excellent stability/sensitivity towards some inorganic compounds and DA, epinephrine and serotonin (5‐HT) hydrochloride . The carbon hybrid material fully‐grown on top of the tetrahedral amorphous carbon (ta‐C) electrode by Sainio et al . was used for the electrocatalytic detection of AA and DA.…”

Section: Electrochemical Sensing Of Da By Using Cnt‐based Materialsmentioning

confidence: 99%

“…The activity of this electrode was found in the order MWCNT-T > MWCNT-COOH > MWCNT-OH > MWCNT-P. [60] Microelectrodes of tungsten (W) wires with uniform layers SWCNT demonstrated outstanding performance and excellent stability/sensitivity towards some inorganic compounds and DA, epinephrine and serotonin (5-HT) hydrochloride. [61] The carbon hybrid material fully-grown on top of the tetrahedral amorphous carbon (ta-C) electrode by Sainio et al [62] was used for the electrocatalytic detection of AA and DA. When the performance of ta-C/CNT electrode and bare ta-C electrode was compared, it was observed that bare electrode cannot resolve both analytes collectively; whereas ta-C/CNT was capable of differentiating these two analytes and LOD of 500 nM for DA was found (Figure 5a, b).…”

Section: Cnts Directly Deposited/grown On Electrodes or Functionalizementioning

confidence: 99%

“…Cyclic voltammetry measurements done in the presence of DA and AA are shown for a) ta-C and b) ta-C + CNT hybrid (Scanning speed 50 mV/s). Reprinted with permission from Ref [62]…”

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confidence: 99%

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Carbon‐Nanotube‐Based Materials for Electrochemical Sensing of the Neurotransmitter Dopamine

2018

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The development of new tools with outstanding performance for monitoring neurotransmitters is a challenging task in neuroscience. Electrochemical probes have attracted tremendous attention for the identification and quantification of neurotransmitters, owing to their demonstrated potential for quick response, real‐time measurements, elevated selectivity and sensitivity. In this Review, we have focused on the recent developments of carbon nanotube (CNT)‐based electrochemical sensors for dopamine detection. The use of CNTs is beneficial for this task, because of their high tensile strength, flexibility, good electrical conductivity, and low thermal expansion coefficient. Therefore, electrochemical sensing approaches with CNTs have opened the door for researchers working towards neurobiomedical applications.

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Section: Electrochemical Sensing Of Da By Using Cnt‐based Materialsmentioning

confidence: 99%

Section: Cnts Directly Deposited/grown On Electrodes or Functionalizementioning

confidence: 99%

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Carbon‐Nanotube‐Based Materials for Electrochemical Sensing of the Neurotransmitter Dopamine

2018

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“…When decorating the surface of carbon with metal, metal oxide/sulfide nanoparticles, the structure becomes catalytically active resulting in new types of catalyst beds suitable for all kinds of chemical reactors (Serp et al, 2003;Halonen et al, 2010). By exploiting the electrical conductivity, in conjunction with the already mentioned advantageous properties, we end up in electrodes for electrochemical sensing (Sainio et al, 2015), energy conversion , storage (Talapatra et al, 2006;Pushparaj et al, 2007), and harvesting (Aitola et al, 2011).…”

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confidence: 99%

Grand Challenges in Translational Materials Research

Kordás

2017

Front. Mater.

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FrOM diScOVerieS tO cOMMercialiZatiOnTechnological progress in our modern society is driven by discovery and deployment of innovation in materials synthesis, design, and application. As such, research related to "Translational Materials, " which are capable of revolutionizing the growth of our civilization play pivotal roles. A key thrust, therefore, should be geared toward the development of novel, innovative, and practical solutions that tackle challenges (Hayden, 2014). The continuous demand for having smaller, better, stronger, lighter, more durable, and efficient tools and devices often with complex functionalities requires a novel approach to advanced materials and design. While materials research is a rather broad field of science and technology, encompassing various disciplines ranging from biotechnology to electronics, and information technology, what makes translational materials research particularly important is the way of thinking and answering a question: How can we translate advances and move ahead toward commercialization? Obviously, it is not the first question what a scientist considers when working on a new topic. Maybe at the time of discovery, there is no technology yet to implement the theory in practice or to scale up a laboratory experiment to a pilot or industrial production. However, great inventions and discoveries shall and will find the way and this is what we ought to contribute to in our Translational Materials Science section of Frontiers in Materials.Historically, the most important man-made materials were those used in construction, transportation, weapons and clothing, etc., putting much weight on the manufacturing of materials such as glasses, ceramics and their composites, metal alloys, and fibrous materials of natural origin. Later, in the twentieth century, the revolutionary results in physics, chemistry, and biology led to the birth of modern materials science, and let us build industries without which we cannot imagine our life as we know it today. Such development has played a key role by providing right impetus to food and pharmaceutical industries, as well as to electronics and information technology. The extremely rapid development of these latter two is unprecedented considering that the first transistor was made in 1947, and the semiconductor industry today has total annual revenue of more than 300 billion USD 1 supplying components and parts for all kinds of electrical appliances.a cOnteMpOrary eXaMple OF a trUe tranSlatiOnal Material: carBOn-BaSed nanOMaterialSBecause of the broad spectrum of materials in science and technology, the number of potentially viable new materials and associated technologies is enormous, making it impossible to provide a complete review within a single article. Here, we give only a few examples to demonstrate how new nanomaterials based on carbon nanostructures could revolutionize some selected fields in electronics, energy, chemical, and environmental applications. Since the discovery of fullerenes (1985), carbonaceous 1 www.statista.c...

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“…The same group then directly grew carbon nanofibers (CNFs) on DLC thin film (Si substrate), which also exhibited wide water window. 85 Notably, the CNFs/DLC electrodes could detect glutamate without using any enzymes.…”

Section: Direct Growth Of Carbon Nanomaterials On Electrode Substratesmentioning

confidence: 99%

Development of Electrochemical Microsensors for in vivo Neurotransmitter Detection

Yang

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Everything that happens in our body and all the interactions we have with the outside world are controlled by our brain. Studies of neurotransmitters are critical for a better understanding of how our brain works. Fast-scan cyclic voltammetry (FSCV) is the most popular electrochemical technique for the in vivo detection of electroactive neurotransmitters and neurochemicals with high temporal resolution. To further improve the detection selectivity, sensitivity, and spatial resolution, carbon nanomaterial based microelectrodes are applied to enhance FSCV for the neurotransmitters detection. In this thesis, I introduce and discuss synthesis and fabrication of several novel carbon nanomaterials, the effect of different surface modifications, and their applications for in vivo neurotransmitter detection.Chapter 1 covers the recent advances in carbon nanomaterial based electrochemical sensors for direct neurotransmitter detection. First, strategies are compared to incorporate carbon nanomaterials into electrochemical sensors for neurotransmitter detection. Second, several new applications are highlighted as well as studies to address the remaining challenges for implementation. Chapters 2-5 describe new carbon nanomaterials and surface treatments for enhanced neurotransmitter detection. The direct growth of CNTs on metal wires is introduced in Chapter 2. Chapter 3 and Chapter 4 introduce three surface modification methods, laser treatment, O2 plasma etching, and anti-static gun treatment, to improve sensitivity, selectivity, and bio-fouling properties on CNT yarn microelectrodes. In Chapter 5, three different types of CNT fiber materials, CNT yarn, PEI/CNT fiber, and CA/CNT fiber, are introduced and compared for the detection of neurotransmitters. Surface physical properties and the electrochemical performance to neurotransmitters are characterized in these studies and correlated using Langmuir adsorption isotherm and diffusion profiles. Moreover, in vivo measurements are performed for dopamine at CNT-Nb microelectrodes and laser treated CNT yarn microelectrodes in Chapter 2 and Chapter 3. The effect of bio-fouling on CNT yarn is discussed in Chapter 4. Yang| iiChapter 6 and Chapter 7 introduce two novel electrode fabrication methods based on 3D printing: a 3D printed mold assisted microelectrode fabrication method and a novel 3D printed electrode design for fiber-like materials. The 3D printing technology with low-cost, high efficiency, and customizable design provides a new path to apply our studies on novel fiber-like carbon nanomaterials and surface modifications to broader applications.Overall, this thesis explores the synthesis and fabrication of several novel carbon nanomaterials, the effect of different surface modifications, and their applications for in vivo neurotransmitters detection. Moreover, the electrode surface properties are also characterized and then correlated to their electrochemical performance. The systematic comparison of different carbon nanomaterials and different surface modificati...

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Integrated Carbon Nanostructures for Detection of Neurotransmitters

Cited by 41 publications

References 21 publications

Carbon‐Nanotube‐Based Materials for Electrochemical Sensing of the Neurotransmitter Dopamine

Carbon‐Nanotube‐Based Materials for Electrochemical Sensing of the Neurotransmitter Dopamine

Grand Challenges in Translational Materials Research

Development of Electrochemical Microsensors for in vivo Neurotransmitter Detection

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