Cases of developed resistance in apple arthropods in North America, including pests and natural enemies, are reviewed with emphasis on the past 20 years since organophosphate (O-P) insecticides were first widely employed. During this period, no key pest, including the codling moth, Laspeyresia pomonella L., has developed resistance to the O-P compound, azinphosmethyl, while a variety of secondary pests including mites, aphids, leafhopper and leafminers, have done so as well as several important natural enemies of these species. The extensive features of DDT, O-P, carbamate and pyrethroid resistance in the predatory mites Tyhplodromus occidentalis Nesbitt and Amblyseius fallacis (Garman) are described. Also discussed is the impact of long-term O-P use and resistance in relation to pest problems, insecticide selectivity and IPM, increased biological control, changing requirements for new chemical insecticides and possibilities for "'resistance management" within the entire arthropod pest natural enemy complex associated with this crop.