Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder

Han, Mengyao; Yuan, Liyun; Huang, Yuwei; Wang, Guiying; Du, Changsheng; Wang, Qingzhong; Zhang, Guoqing

doi:10.3389/fpsyt.2022.980315

Cited by 5 publications

(2 citation statements)

References 70 publications

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“…These observations imply neuronal atrophy within these regions. [ 29 ] Animal experiments demonstrate that animals modeling depression exhibit reduced dimensions of hippocampal neurons, processes, nuclear atrophy, and even neuronal loss, accompanied by a substantial reduction in synaptic density. [ 30 ] Conversely, the administration of antidepressants has been shown to promote the formation of hippocampal neuron synapses and prevent neuronal atrophy, consequently mitigating depression-like behaviors.…”

Section: Depression and Central Nervous Inflammationmentioning

confidence: 99%

Progress of plant polyphenol extracts in treating depression by anti-neuroinflammatory mechanism: A review

Guo,

Yang

2024

Medicine

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There is a growing body of evidence supporting the involvement of central nervous system inflammation in the pathophysiology of depression. Polyphenols are a diverse group of compounds known for their antioxidative and anti-inflammatory properties. They offer a promising and effective supplementary approach to alleviating neuropsychiatric symptoms associated with inflammation-induced depression. This paper provides a summary of the potential anti-neuroinflammatory mechanisms of plant polyphenol extracts against depression. This includes direct interference with inflammatory regulators and inhibition of the expression of pro-inflammatory cytokines. Additionally, it covers downregulating the expression of pro-inflammatory cytokines by altering protein kinases or affecting the activity of the signaling pathways that they activate. These pathways interfere with the conduction of signaling molecules, resulting in the destruction and reduced synthesis of all inflammatory mediators and cytokines. This reduces the apoptosis of neurons and plays a neuroprotective role. This paper provides a theoretical basis for the clinical application of plant polyphenols.

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Section: Depression and Central Nervous Inflammationmentioning

confidence: 99%

Progress of plant polyphenol extracts in treating depression by anti-neuroinflammatory mechanism: A review

Guo,

Yang

2024

Medicine

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“…Nonetheless, computational approaches have been developed for the prioritization of disease-gene candidates ( 72 ). This advancement has enabled researchers to elucidate co-expression patterns through network analysis ( 73 ).…”

Section: Levels Of Analysismentioning

confidence: 99%

Understanding mental health through computers: An introduction to computational psychiatry

Martinez

Santamaría-García²

2023

Front. Psychiatry

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Computational psychiatry recently established itself as a new tool in the study of mental disorders and problems. Integration of different levels of analysis is creating computational phenotypes with clinical and research values, and constructing a way to arrive at precision psychiatry are part of this new branch. It conceptualizes the brain as a computational organ that receives from the environment parameters to respond to challenges through calculations and algorithms in continuous feedback and feedforward loops with a permanent degree of uncertainty. Through this conception, one can seize an understanding of the cerebral and mental processes in the form of theories or hypotheses based on data. Using these approximations, a better understanding of the disorder and its different determinant factors facilitates the diagnostics and treatment by having an individual, ecologic, and holistic approach. It is a tool that can be used to homologate and integrate multiple sources of information given by several theoretical models. In conclusion, it helps psychiatry achieve precision and reproducibility, which can help the mental health field achieve significant advancement. This article is a narrative review of the basis of the functioning of computational psychiatry with a critical analysis of its concepts.

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Brain Specific RagA Overexpression Triggers Depressive‐Like Behaviors in Mice via Activating ADORA2A Signaling Pathway

Zhao,

Sun,

Feng

et al. 2024

Advanced Science

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Neuroinflammation hallmarks the pathology of depression although the etiological complexity has not yet been resolved. Previous studies demonstrate that bacterial lipopolysaccharide induces depressive‐like behaviors by activating RagA‐mTOR‐p70S6K signaling pathway. The current project aims to investigate whether and how brain‐specific RagA overexpression triggers depressive‐like behaviors in mice. Full‐length RagA cDNA is cloned into the mammalian expression vector under the control of brain specific promoter, and subsequently overexpressed in the brain of mouse embryos. Indeed, RagA transgenic mice exhibit depressive‐like behaviors and memory impairments. RNA‐seq profiling of the prefrontal cortex (PFC) transcriptome highlights adenosine A2a receptor (ADORA2A) as a key differentially expressed gene (DEG). Western blotting confirms that ADORA2A and phospho‐p70S6K are markedly elevated in RagA transgenic mice. Behavioral assessments demonstrate that ADORA2A inhibitor istradefylline markedly attenuates depressive‐like behaviors. Further metabolomics reveals that N‐acetylserotonin and several depression‐related metabolites are downregulated while proteomic profiling showed that OLIG1 and other proteins are significantly regulated in RagA transgenic mice. Collectively, RagA overexpression alters the expression patterns of signaling proteins and the metabolism of depression‐associated metabolites. RagA may cause depressive‐like behaviors in mice via activating p70S6K/ADORA2A signaling pathway. Thus, RagA‐p70S6K‐ADORA2A signaling pathway may be a target for the development of new antidepressant therapies.

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Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder

Cited by 5 publications

References 70 publications

Progress of plant polyphenol extracts in treating depression by anti-neuroinflammatory mechanism: A review

Progress of plant polyphenol extracts in treating depression by anti-neuroinflammatory mechanism: A review

Understanding mental health through computers: An introduction to computational psychiatry

Brain Specific RagA Overexpression Triggers Depressive‐Like Behaviors in Mice via Activating ADORA2A Signaling Pathway

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