Indubitably, African countries face a confounding entrepreneurial environment, which informs their low growth rates. This paper, through a literature review methodology, discusses pertinent factors that confound entrepreneurial environment of many African countries. These include unfair and skewed trade practices between developing countries and the western world, failure for African countries to process their goods, poor policy environment on entrepreneurship, high interest rates by the financial institutions, slowed border clearance of goods, cumbersome trade restrictions and control, and visa requirements to enter into some neighbouring countries such as South Africa. The paper calls for adoption of modern information technology, visa imposition to be done away with, governments to initiate policies to train potential business entrants, countries to ensure they process their primary products, lending rates to be lowered, ensure businesses operate through visible business plans, improving transport networks, and inclusion of business education in the curriculums of all the learning institutions.