2023
DOI: 10.1186/s13048-023-01193-3
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Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

Abstract: Background This study aimed to compare the characteristics of the gut microbiota and their metabolite profiles between polycystic ovary syndrome (PCOS) and orlistat-treated PCOS rats (ORL-PCOS), which could help to better understand the underlying mechanism of the effect of orlistat on PCOS. Methods PCOS rat models were established using letrozole combined with a high-fat diet. Ten rats were randomly selected as a PCOS control group (PCOS). The oth… Show more

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Cited by 4 publications
(2 citation statements)
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“…Finally, we shall mention that Table 1 has only attempted to reflect the changes in the microbiota associated with physiological weight loss, as a result of a nutritional intervention. Pharmacological interventions described for weight loss, such as the use of Orlistat or GLP-1 agonists, were excluded due to the demonstrated role of these drugs on the intestinal microbial composition per se [53,54], which may mask the results observed as a consequence of weight loss.…”
Section: Microbiota As Weight Loss Predictor After Dietary Interventionmentioning
confidence: 99%
“…Finally, we shall mention that Table 1 has only attempted to reflect the changes in the microbiota associated with physiological weight loss, as a result of a nutritional intervention. Pharmacological interventions described for weight loss, such as the use of Orlistat or GLP-1 agonists, were excluded due to the demonstrated role of these drugs on the intestinal microbial composition per se [53,54], which may mask the results observed as a consequence of weight loss.…”
Section: Microbiota As Weight Loss Predictor After Dietary Interventionmentioning
confidence: 99%
“…Overall, our objective was to provide a theoretical foundation for the application of Res and the identification of new medications. After 1 week of adaptation, 60 rats were randomly divided into a normal control group, a model group, a positive-control group and high-, medium-and low-dose Res groups, with 10 rats in each group (Johnson et al, 2012;Xu et al, 2021;Yang et al, 2023). Except for the blank group, the GN model was established in groups as previously described (Xiaomin Yafei Liu, 2020).…”
Section: Introductionmentioning
confidence: 99%