Integrated Genomic Approaches to Enhance Genetic Resistance in Chickens

Cheng, Hans H.; Kaiser, Pete; Lamont, Susan J.

doi:10.1146/annurev-animal-031412-103701

Cited by 39 publications

(42 citation statements)

References 132 publications

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“…Although a lack of LN is consistent with the loss of the MHC-linked TNF family members, the presence of FDC and GC must be regulated by other factors yet to be defined. Genome projects in chickens and other birds will permit analysis of expression of the chemokine and cytokine network in this vertebrate class (Cheng et al 2013). …”

Section: Discussionmentioning

confidence: 99%

Emergence and Evolution of Secondary Lymphoid Organs

Neely

Flajnik

2016

Annu. Rev. Cell Dev. Biol.

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For effective adaptive immunity to foreign antigens (Ag), secondary lymphoid organs (SLO) provide the confined environment in which Ag-restricted lymphocytes, with very low precursor frequencies, interact with Ag on Ag-presenting cells (APC). The spleen is the primordial SLO, arising in conjunction with adaptive immunity in early jawed vertebrates. The spleen, especially the spleen’s lymphoid compartment, the white pulp (WP), has undergone numerous modifications over evolutionary time. We describe the progressive advancement of splenic WP complexity, which evolved in parallel with the increasing functionality of adaptive immunity. The Ag-presenting function of follicular dendritic cells (FDC) also likely emerged at the inception of adaptive immunity, and we propose that a single type of hematopoietically derived APC displayed Ag to both T and B cells. A dedicated FDC, derived from a vascular precursor, is a recent evolutionary innovation that likely permitted the robust affinity maturation found in mammals.

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Section: Discussionmentioning

confidence: 99%

Emergence and Evolution of Secondary Lymphoid Organs

Neely

Flajnik

2016

Annu. Rev. Cell Dev. Biol.

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“…As for MD resistance, the genetic characterizations of the disease have been explored by investigating differential RNA transcripts [34], the QTL mapping [13,14,15], and other integrated methods over the past years [35]. CNVs related to MD resistance were reported before using array CGH and next-generation sequencing [36,37].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Copy Number Variation’s Potential Role in Marek’s Disease

Ding

et al. 2017

IJMS

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Marek’s Disease (MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. Chicken Lines 63 and 72, as well as their recombinant congenic strains (RCS) with varied susceptibility to MD, are ideal models to study the complex mechanisms of genetic resistance to MD. In this study, we investigated copy number variation (CNV) in these inbred chicken lines using the Affymetrix Axiom HD 600 K SNP genotyping array. We detected 393 CNV segments across all ten chicken lines, of which 12 CNVs were specifically identified in Line 72. We then assessed genetic structure based on CNV and observed markedly different patterns. Finally, we validated two deletion events in Line 72 and correlated them with genes expression using qPCR and RNA-seq, respectively. Our combined results indicated that these two CNV deletions were likely to contribute to MD susceptibility.

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“…SP can cause high mortality rates in chicks under 20 days old and yet few symptoms in adult chickens. In the poultry industry, disease resistance is an important trait with substantial economic value and disease control is drawing more and more public concerns (Cheng et al, 2013). Existing disease management is not enough to prevent disease outbreaks and genetic selection for resistant birds has been regarded as a promising complementary strategy.…”

Section: Introductionmentioning

confidence: 99%

The Genetic Architecture of Early Body Temperature and Its Correlation With Salmonella Pullorum Resistance in Three Chicken Breeds

Nie

Liu

et al. 2020

Front. Genet.

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Newborn chicks are vulnerable to bacterial infections and not good at regulating body temperature. There is a close relationship between thermal regulation and immunity, however, the underlying mechanism is not well understood. Salmonella Pullorum (SP) is a major concern in developing countries and causes significant economic losses in poultry industry. Early body temperature (EBT) has previously shown to be correlated with host immunity and resistance to pullorum disease. In this study, we challenged three independent chick populations (Beijing You, Dwarf and Rhode Island Red) with SP at 4 days of age, and rectal temperature was measured before and after the SP attack from 2 to 7 days of age. Host defense to SP was evaluated by survival and spleen SP carrier status. The results showed that chicks with higher EBT before SP infection tend to have higher resistance to later SP attack in two populations (Dwarf and Beijing You). The association between EBT before SP attack and SP resistance was non-significant in Rohde Island Red population (P = 0.06), but the trend was consistent with the other two populations. We also found low to moderate heritability in all three populations for EBT before and after the SP attack ranging from 0.14 to 0.20. Genome-wide association studies identified several genomic regions and biological pathways determining EBT before SP attack, which provides candidate functional genes of this trait. Our results reveal the genetic determination of EBT, and the relationship between EBT and SP resistance, providing an alternative strategy for improving SP resistant activities in chicken.

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Integrated Genomic Approaches to Enhance Genetic Resistance in Chickens

Cited by 39 publications

References 132 publications

Emergence and Evolution of Secondary Lymphoid Organs

Emergence and Evolution of Secondary Lymphoid Organs

Characterization of Copy Number Variation’s Potential Role in Marek’s Disease

The Genetic Architecture of Early Body Temperature and Its Correlation With Salmonella Pullorum Resistance in Three Chicken Breeds

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