Integrated imaging - the complementary roles of radiology and nuclear medicine

Jm, Warwick; Jw, Lotz

doi:10.4102/sajr.v17i4.11

Cited by 3 publications

(2 citation statements)

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“…The predominant use of diuresis renography among adults in this study is noteworthy. It contrasts with the reports from developed countries, where diuresis renography is predominantly used in children for the early detection and management of congenital abnormalities of the kidneys and urinary tracts (CAKUT) [ 32 – 35 ]. In Nigeria, CAKUT is responsible for between 7.8% and 17.5% of paediatric admissions and a major cause of chronic kidney disease among children [ 32 , 36 – 38 ].…”

Section: Discussionmentioning

confidence: 97%

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

Orunmuyi¹,

Lawal²,

Omofuma³

et al. 2020

ecancer

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Background: Nuclear medicine needs better integration into the Nigerian health system. To understand the relevant public health initiatives that will be required, this study assessed the pattern of nuclear medicine imaging services at the first nuclear medicine centre in Nigeria from January 2010 to December 2018. Methods: The data of consecutive nuclear medicine (NM) scans performed between 1st January 2010 and 31st December 2018 at the NM department in a tertiary hospital in Nigeria were extracted from patient records and analysed using SAS version 9.4 (SAS Institute, Cary, NC). The National Cancer Institute's Joinpoint software and QCIS (QGIS project) were used to estimate imaging trends and geographical spread of patients. Results: An average of 486 scans per year was performed during the study period. Patients travelled from 32 of Nigeria's 36 states, and the majority (65%) travelled more than 100 km to obtain NM scans. Bone scans accounted for 88.1% of the studies. The remainder were renal scintigraphy (7.3%), thyroid scans (2.5%), whole-body iodine scans (1.7%) and others (0.4%). Conclusions: NM in Nigeria appears underutilised. Furthermore, the studies to characterise the access gaps and implementation needs will contribute to the design of practical strategies to strengthen NM services in Nigeria.

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Section: Discussionmentioning

confidence: 97%

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

Orunmuyi¹,

Lawal²,

Omofuma³

et al. 2020

ecancer

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“…Presently nuclear medicine techniques involving single photon emission computed tomography (SPECT) and positron emission tomography (PET) along with the more familiar imaging techniques such as, conventional radiography (X rays), computed tomography (CT) scans, magnetic resonance (MR) imaging, and ultrasound play a critical role in tumor diagnosis (Dodd, ; Rudin & Weissleder, ). The principal advantage of nuclear imaging techniques lies in its ability to not only identify the location of cancerous and diseased tissue, but also to provide simultaneous information regarding its physiological state, which is important to devising strategies to effectively combat the disease (Holland, Ferdani, Anderson, & Lewis, ; Warwick & Lotz, ). Diagnostic radiopharmaceuticals, having the capability of noninvasively detecting tumors at an early stage of the disease play a critical role in the rapid and early diagnosis of tumors making development of radiolabeled agents with improved characteristics for tumor diagnosis an active area of research in the radiopharmaceutical sciences.…”

Section: Introductionmentioning

confidence: 99%

The potential of radiolabeled chemotherapeutics in tumor diagnosis: Preliminary investigations with ⁶⁸Ga‐gemcitabine

Ghosh

Das

Sarma

et al. 2018

Drug Development Research

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Preclinical Research & Development Gemcitabine, a nucleoside analog, is a well-known chemotherapeutic drug that is used either alone or with other agents to treat a wide variety of cancers. The aim of the present work was to evaluate the potential of Ga-labeled gemcitabine for its application in positron emission tomography (PET) imaging of tumorous lesions. Gemcitabine was coupled with p-NCS-benzyl-DOTA in order to facilitate radiolabeling with Ga. The gemcitabine-p-NCS-benzyl-DOTA was radiolabeled with Ga, obtained from a Ge/ Ga radionuclide generator. The radiolabeled product was characterized by high performance liquid chromatography (HPLC) and its tumor specificity was evaluated by biodistribution studies in Swiss mice bearing fibrosarcoma tumors. Preliminary bioevaluation study showed good tumor uptake within 1 hr post-administration [2.5% Injected Activity (IA) per g of tumor] with rapid renal clearance (>90% IA) and a high tumor to muscle ratio. Ga-gemcitabine may have potential as a PET agent for tumor imaging.

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Radiological changes among artistic gymnasts in Gauteng Province

2014

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Background. The skeletal immaturity of competitive female gymnasts allows for a unique physiological predisposition to injuries as a result of the spine, limbs, ankles and wrists still growing. Studies have shown that lower back (spinal) injuries account for approximately 12% of injuries in female gymnasts. Objectives. The primary objective of the study was to determine the prevalence of radiological changes in female artistic gymnasts in South Africa. A further objective was to determine whether these radiological changes were associated with symptoms and with the amount of time spent training. Methods. A sample of 40 female artistic gymnasts with a mean of age 15.2 years (range 10 -31) was included in the study. Thirty-one were active gymnasts and nine were retired at the time of the current study. Measuring instruments included questionnaires and X-rays. Results. X-ray analysis of symptomatic versus asymptomatic gymnasts showed no significant differences. Of the 18 gymnasts training <25 h/week, 13 (72%) had degenerative changes detectable by X-ray. Of the 22 gymnasts training >25 h/week, 15 (68%) had degenerative changes detected by X-ray. Radiological changes were higher than those in other studies. Conclusion. The prevalence of radiological changes was higher than international norms, however there was little difference between symptomatic and asymptomatic gymnasts. Patient self-reports of symptoms had little value in diagnosing change in the lumbar spine. Training duration affected the prevalence of changes in the lumbar spine and could be related to conditioning and experience.

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Integrated imaging - the complementary roles of radiology and nuclear medicine

Abstract: This article was first published in the August 2013 issue of Continuing Medical Education (Vol. 31, Issue 8), and is reproduced here because of its topicality and desirability of reaching a broader audience.

Cited by 3 publications

References 12 publications

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

The potential of radiolabeled chemotherapeutics in tumor diagnosis: Preliminary investigations with ⁶⁸Ga‐gemcitabine

Radiological changes among artistic gymnasts in Gauteng Province

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Integrated imaging - the complementary roles of radiology and nuclear medicine

Abstract: This article was first published in the August 2013 issue of Continuing Medical Education (Vol. 31, Issue 8), and is reproduced here because of its topicality and desirability of reaching a broader audience.

Cited by 3 publications

References 12 publications

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

The potential of radiolabeled chemotherapeutics in tumor diagnosis: Preliminary investigations with 68Ga‐gemcitabine

Radiological changes among artistic gymnasts in Gauteng Province

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Resources

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The potential of radiolabeled chemotherapeutics in tumor diagnosis: Preliminary investigations with ⁶⁸Ga‐gemcitabine