Integrated in-situ product removal process concept for itaconic acid by reactive extraction, pH-shift back extraction and purification by pH-shift crystallization

Eggert, Armin; Maßmann, Tim; Kreyenschulte, Dirk; Becker, Marco; Heyman, Benedikt; Büchs, Jochen; Jupke, Andreas

doi:10.1016/j.seppur.2019.01.011

Cited by 35 publications

(28 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11,12 The efficiency of integrated separation and purification strategies such as crystallization and extraction is often determined by dissociation of the acids as, for example, only the associated form of the acids is extracted. 13–16 Therefore, robust and time-resolved analytics to measure the concentration and dissociation of the different acid species are necessary for modeling, control, and optimization of downstream process unit operations. 17…”

Section: Introductionmentioning

confidence: 99%

Inline Raman Spectroscopy and Indirect Hard Modeling for Concentration Monitoring of Dissociated Acid Species

et al. 2020

View full text Add to dashboard Cite

We propose an approach for monitoring the concentration of dissociated carboxylic acid species in dilute aqueous solution. The dissociated acid species are quantified employing inline Raman spectroscopy in combination with Indirect Hard Modeling (IHM) and Multivariate Curve Resolution (MCR). We introduce two different titration-based Hard Model (HM) calibration procedures for a single mono- or polyprotic acid in water with well-known (method A) or unknown (method B) acid dissociation constants pKa. In both methods, spectra of only one acid species in water are prepared for each acid species. These spectra are used for the construction of HMs. For method A, the HMs are calibrated with calculated ideal dissociation equilibria. For method B, we estimate pKa values by fitting ideal acid dissociation equilibria to acid peak areas that are obtained from a spectral HM. The HM in turn is constructed on the basis of MCR data. Thus, method B on the basis of IHM is independent of a priori known pKa values, but instead provides them as part of the calibration procedure. As a detailed example, we analyze itaconic acid in aqueous solution. For all acid species and water, we obtain low HM errors of less than 2.87Ã10-4 mol mol-1 in the cases of both method A and B. With only four calibration samples, IHM yields more accurate results than partial least squares regression. Furthermore, we apply our approach to formic, acetic, and citric acid in water, thereby verifying its generalizability as a process analytical technology for quantitative monitoring of processes containing carboxylic acids.

show abstract

Section: Introductionmentioning

confidence: 99%

Inline Raman Spectroscopy and Indirect Hard Modeling for Concentration Monitoring of Dissociated Acid Species

et al. 2020

View full text Add to dashboard Cite

show abstract

“…8 The toxicity of solvents used for reactive extraction often is reported in the literature concerning bacteria. [36][37][38] It has been suggested that the addition of a biocompatible but poor extractive solvent (inert solvent) to the active alcohol-type diluent can improve the biocompatibility of the extracting phase while maintaining an adequate extraction performance. [38][39][40][41][42] Solvents may affect cells at two different levels: by direct contact with the immiscible part of the solvent (phase-level toxicity) and interaction with the water-soluble solvent molecules (molecular-level toxicity).…”

Section: Introductionmentioning

confidence: 99%

“…[36][37][38] It has been suggested that the addition of a biocompatible but poor extractive solvent (inert solvent) to the active alcohol-type diluent can improve the biocompatibility of the extracting phase while maintaining an adequate extraction performance. [38][39][40][41][42] Solvents may affect cells at two different levels: by direct contact with the immiscible part of the solvent (phase-level toxicity) and interaction with the water-soluble solvent molecules (molecular-level toxicity). 40,43,44 The toxicity of several organic solvents commonly used for the reactive extraction of carboxylic acids has been assessed on different strains of microorganisms, 18,36,41,43,45 but the variable and often contradictory results suggest that the selection of a biocompatible extraction phase depends strongly on the microorganism strain used.…”

Section: Introductionmentioning

confidence: 99%

“…However, its application for the ISPR of 3‐HP during its production by L. reuteri had a strong inhibitory effect on the cells, resulting in reduced 3‐HP production (56% of the total production compared to the process without ISPR), even though the liquid–liquid extraction was assisted by a Hollow Fibres Membrane Contactor (HFMC) that avoids the direct contact of the organic phase with the cells . The toxicity of solvents used for reactive extraction often is reported in the literature concerning bacteria . It has been suggested that the addition of a biocompatible but poor extractive solvent (inert solvent) to the active alcohol‐type diluent can improve the biocompatibility of the extracting phase while maintaining an adequate extraction performance …”

Section: Introductionmentioning

confidence: 99%

“…The toxicity of solvents used for reactive extraction often is reported in the literature concerning bacteria . It has been suggested that the addition of a biocompatible but poor extractive solvent (inert solvent) to the active alcohol‐type diluent can improve the biocompatibility of the extracting phase while maintaining an adequate extraction performance …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Organic phase screening for in‐stream reactive extraction of bio‐based 3‐hydroxypropionic acid: biocompatibility and extraction performances

Sánchez-Castañeda

Moussa

Ngansop

et al. 2019

J of Chemical Tech & Biotech

View full text Add to dashboard Cite

BACKGROUND 3‐Hydroxypropionic acid (3‐HP) production through glycerol bioconversion by Lactobacillus reuteri suffers from low yields and productivities due to product inhibition. Reactive extraction assisted by a Hollow Fibre Membrane Contactor (HFMC) is a promising strategy for process intensification. However, the use of this integrated system is hindered by extraction phase toxicity towards the microorganism. This study describes a solvent selection strategy based on extraction performance (extraction yield and viscosity, related to mass transfer), and a low solvent toxicity, in order to find an extraction phase composition that allows continuous in stream extraction of 3‐HP. RESULTS Inert diluent addition to a trioctylamine (TOA)‐decanol mixture decreased its toxicity and viscosity but decreased extraction yield. The linear and ramified long‐chain alcohols tested showed that increasing the number of carbon atoms decreased extraction performance as well as toxicity. Ramified alcohols showed the lowest extraction performance. Didodecylmethylamine (DDMA) gave higher extraction yield and lower solvent toxicity than TOA. Flow cytometry with dual staining for cell membrane integrity and enzymatic activity proved to give concordant and complementary information with cell bioconversion ability, being an adequate and quick method for solvent toxicity assessment. The selected organic phase consisted of 20% DDMA, 47% dodecanol and 33% dodecane by volume, and can be used for in‐stream extraction of 3‐HP produced by L. reuteri. CONCLUSIONS The integrated selection criteria proposed in this study – extraction yield, solvent viscosity and toxicity – provide key information for choosing an organic phase with the best trade‐off between extraction performance and biocompatibility. © 2019 Society of Chemical Industry

show abstract

Elektrochemische pH‐T‐swing Extraktion von biobasierter Itaconsäure

Gausmann

Kocks

Jupke

2020

Chemie Ingenieur Technik

View full text Add to dashboard Cite

Integrated in-situ product removal process concept for itaconic acid by reactive extraction, pH-shift back extraction and purification by pH-shift crystallization

Cited by 35 publications

References 40 publications

Inline Raman Spectroscopy and Indirect Hard Modeling for Concentration Monitoring of Dissociated Acid Species

Inline Raman Spectroscopy and Indirect Hard Modeling for Concentration Monitoring of Dissociated Acid Species

Organic phase screening for in‐stream reactive extraction of bio‐based 3‐hydroxypropionic acid: biocompatibility and extraction performances

Elektrochemische pH‐T‐swing Extraktion von biobasierter Itaconsäure

Contact Info

Product

Resources

About