Integrated lipids biomarker of the prediabetes and type 2 diabetes mellitus Chinese patients

Yang, Jiaying; Wang, Mei; Yang, Di; Han, Yaling; Wang, Zhigang; Yan, Dongpeng; Guo, Na

doi:10.3389/fendo.2022.1065665

Cited by 9 publications

(6 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated that increased levels of LPC with saturated FA, such as C14:0, act as proinflammatory mediators and are associated with inflammatory diseases. [95][96][97][98][99] Conversely, LPC 20:5 is typically considered anti-inflammatory mediator. 99 Regarding the sphingomyelin (SM) profile, this lipid class constitutes approximately 20% of total plasma phospholipids and is the most abundant sphingolipid class in lipoproteins, especially low-density lipoproteins (LDL).…”

Section: Discussionmentioning

confidence: 99%

“…While levels of LPC 14:0 and LPC 22:4(with a very low abundance) were found to be increased, the LPC 20:5 was decreased in MCADD children. Previous studies have demonstrated that increased levels of LPC with saturated FA, such as C14:0, act as pro‐inflammatory mediators and are associated with inflammatory diseases 95–99 . Conversely, LPC 20:5 is typically considered anti‐inflammatory mediator 99 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma lipidomics analysis reveals altered profile of triglycerides and phospholipids in children with Medium‐Chain Acyl‐CoA dehydrogenase deficiency

Guerra,

Ferreira,

Maurício

et al. 2024

J of Inher Metab Disea

View full text Add to dashboard Cite

Medium‐chain acyl‐CoA dehydrogenase deficiency (MCADD) is the most prevalent mitochondrial fatty acid β‐oxidation disorder. In this study, we assessed the variability of the lipid profile in MCADD by analysing plasma samples obtained from 25 children with metabolically controlled MCADD (following a normal diet with frequent feeding and under l‐carnitine supplementation) and 21 paediatric control subjects (CT). Gas chromatography–mass spectrometry was employed for the analysis of esterified fatty acids, while high‐resolution C18‐liquid chromatography‐mass spectrometry was used to analyse lipid species. We identified a total of 251 lipid species belonging to 15 distinct lipid classes. Principal component analysis revealed a clear distinction between the MCADD and CT groups. Univariate analysis demonstrated that 126 lipid species exhibited significant differences between the two groups. The lipid species that displayed the most pronounced variations included triacylglycerols and phosphatidylcholines containing saturated and monounsaturated fatty acids, specifically C14:0 and C16:0, which were found to be more abundant in MCADD. The observed changes in the plasma lipidome of children with non‐decompensated MCADD suggest an underlying alteration in lipid metabolism. Therefore, longitudinal monitoring and further in‐depth investigations are warranted to better understand whether such alterations are specific to MCADD children and their potential long‐term impacts.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma lipidomics analysis reveals altered profile of triglycerides and phospholipids in children with Medium‐Chain Acyl‐CoA dehydrogenase deficiency

Guerra,

Ferreira,

Maurício

et al. 2024

J of Inher Metab Disea

View full text Add to dashboard Cite

show abstract

“…Previous studies reported that Cer(d18:1/20:0) had a significant predictive value for the occurrence of type 2 diabetes in the healthy population. 30 , 31 And interventions in Cer(d18:1/14:0) and Cer(d18:1/16:0) may improve the outcomes of patients with type 2 diabetes. 32 , 33 It is revealed that very long chain ceramides (C24, C26, and C26:1) are associated with the development of kidney injury.…”

Section: Discussionmentioning

confidence: 99%

Association Between Plasma Ceramides and One-Year Mortality in Patients with Acute Coronary Syndrome: Insight from the PEACP Study

Li¹,

Li²,

Yu³

et al. 2023

CIA

View full text Add to dashboard Cite

Background The plasma lipidome profile is likely to improve risk stratification in patients with acute coronary syndrome (ACS) and predict cardiovascular events for secondary disease prevention. Ceramides are involved in the initiation or acceleration of several key pathophysiological processes in atherosclerosis. This study evaluated whether plasma ceramide levels at admission was associated with one-year mortality in patients with ACS. Methods In total, 826 patients with ACS from a prospective multicenter study for early evaluation of acute chest pain were enrolled. High-performance liquid chromatography with tandem mass spectrometry (LC/MS) was used to measure the plasma levels of eleven ceramides (C16–C26). The primary outcome was all-cause mortality, and the secondary outcome was cardiac mortality during the one-year follow-up. The relationship between the ceramide levels and mortality was evaluated by Cox regression analysis. The receiver operating characteristic (ROC) curve was established to evaluate discrimination of ceramides. Results Eighty-eight (10.7%) patients died after a 12-month follow-up. Five ceramides (C16:0, C18:0, C20:0, C24:1 and C24:2) and their ratios to Cer(d18:1/24:0) were independently associated with the risk of all-cause death and cardiac death. Combining the Global Registry of Acute Coronary Events (GRACE) score with ceramides and their ratios to Cer(d18:1/24:0) had areas under ROC curves ranging from 0.778–0.804 (P<0.001) for all-cause mortality, which was greater than that of the GRACE score alone. Conclusion Measurements of long-chain ceramides and very-long-chain ceramides may help in identifying a high risk of mortality beyond traditional assessment tools in patients with ACS. Trial Registration clinicaltrials.gov, identifier: NCT04122573.

show abstract

“… 85 Increased de novo ceramide synthesis in the endoplasmic reticulum can activate protein phosphatase 2A (PPA2), inactivate protein kinase B (Akt) in the insulin signaling pathway and ultimately inhibit insulin sensitivity and β-cell function. 86 As one of the most prominent phospholipid components in animal cell membranes, sphingomyelin has been observed to correlate inversely with GDM in several studies. 68 Furthermore, downregulated sphingolipid metabolism may be an early predictor of the transition from GDM to T2DM.…”

Section: Urine Metabolomicsmentioning

confidence: 99%

Using metabolomics and proteomics to identify the potential urine biomarkers for prediction and diagnosis of gestational diabetes

Yu,

Ren,

Ren

et al. 2024

eBioMedicine

View full text Add to dashboard Cite

Integrated lipids biomarker of the prediabetes and type 2 diabetes mellitus Chinese patients

Cited by 9 publications

References 95 publications

Plasma lipidomics analysis reveals altered profile of triglycerides and phospholipids in children with Medium‐Chain Acyl‐CoA dehydrogenase deficiency

Plasma lipidomics analysis reveals altered profile of triglycerides and phospholipids in children with Medium‐Chain Acyl‐CoA dehydrogenase deficiency

Association Between Plasma Ceramides and One-Year Mortality in Patients with Acute Coronary Syndrome: Insight from the PEACP Study

Using metabolomics and proteomics to identify the potential urine biomarkers for prediction and diagnosis of gestational diabetes

Contact Info

Product

Resources

About