Introduction: Sick children will be at risk of experiencing growth and development disorders and experiencing severe conditions to decreased quality of life. Quality of care through proper management of sick children under five is a priority. However, in the field of pediatric nursing, there are still obstacles to the application of family empowerment in caring for sick children, so it is important to examine a literature review with a philosophical approach the application of family empowerment in caring for sick children, as an effort to optimize the care of sick children under-five. Method: This study was based on the results of the Literature Review. Articles were obtained from 3 databases, namely Scopus, Science Direct and PubMed. The keywords used in searching the literature in this study were ((parent) OR (mother) AND (parental AND empowerment) OR (engagement) AND (children) OR (sick AND children)). Articles searched from 2018-2022, which were open access and in English, from this literature review search, found 12 articles. Result: Based on a philosophical approach of family empowerment in the care of sick children under-five, family empowerment interventions with the principle of involving families in care, and increasing family knowledge and skills in caring for sick children can be implemented as an effort to optimize care for sick toddlers. Conclusion: The results of this literature review can be used as a basis for nursing interventions that require parental involvement in caring for sick children. Family empowerment programs that are planned and structured can be applied in the care of sick children at home or in the hospital.